Abstract: Described is a process for delivering a biologically active compound to a cell by reversibly linking the compound to a membrane active polymer. In particular, polymer-polynucleotide conjugates are described. Methods for reversibly modifying the polymers to decrease cellular toxicity and improve efficacy are provided.
Type:
Grant
Filed:
February 17, 2004
Date of Patent:
October 19, 2010
Assignee:
Roche Madison Inc.
Inventors:
David B. Rozema, Darren Wakefield, Jon A Wolff, Kirk Ekena, James E. Hagstrom