Abstract: The purpose of this study was to identify the periodontal regeneration factors in enamel protein shown to induce cementum- and osteo-promotive activities in vivo. The cementum regeneration (CR), a part of periodontal regeneration, was examined by using experimental cavities prepared in a buccal dehiscence dog model. The CR activity was found in the aggregate consisted of sheath proteins along with a small amount of amelogenins separated from newly formed secretory enamel. The sheath proteins were purified to be homogeneous, and examined for the alkaline phosphatase (ALP) inducing activity of human periodontal ligament (HPDL) cells. Application of 17 kDa sheath protein induced ALP activity in HPDL cells. Peptides synthesized from the sheath protein sequence also showed ALP inducing activity. The 17 kDa sheath protein has cell differentiation activity.

Abstract: The present invention is related to new 2-oxo-cyclic compound the process for preparing them and a pharmaceutical composition comprising the same. The present invention provides a pharmaceutical composition for preventing and treating the inflammatory disease comprising the pain or inflammation caused by rheumatic disease, for example, rheumatoid arthritis, spondyloarthopathies, gout, osteoarthritis, systemic lupus erythematosus and juvenile arthritis, and inflammatory syndrome for example, from myositis, gingivitis, synovitis, ankylosing spondylitis, burstitis, burns and scar, inflammatory Crohn's disease, Types I diabetes. therefore, it can be used as the therapeutics for treating and preventing inflammatory diseases.

Abstract: A hand-held device (10) for creating a pressure change in a person's ear canal. It has an interior space forming an air chamber (50), a plunger (58) and a valve means (52) frictionally engaged with said plunger (58), a tube (14) with an earpiece (48), and a finger-actuated diaphragm (60) in an external wall of the air chamber (50). The diaphragm (60) moves the plunger (58) from a resting position, and in a first direction. A spring (56) returns the diaphragm (60) to its undepressed position. Initial movement of the plunger (58) in said first direction from said resting position displaces the valve (52) from a first position to a second position at which the valve means (52) is stopped from further movement in said first direction. Further movement of the plunger (58) in said first direction causes the plunger (58) to slide relative to the valve (52). The device (10) is intended for treatment of Mënière's disease and ear pain from other causes.

Abstract: The present invention relates to a method for preparing purified extract from wild ginseng showing anticancer activity such as inhibitory of cancer cell adherence, inhibitory of cancer cell metastasis and immunostimulating effect and a composition comprising the same prepared by inventive method. The composition have potent anticancer activity, therefore, it can be used as the therapeutics for treating and preventing various cancer diseases.

Abstract: The present invention is related to novel use of 2-oxo-heterocyclic compounds having anticancer activity and the process for preparing them and a pharmaceutical composition comprising the same.

Abstract: The purpose of this study was to identify the periodontal regeneration factors in enamel protein shown to induce cementum- and osteo-promotive activities in vivo. The cementum regeneration (CR), a part of periodontal regeneration, was examined by using experimental cavities prepared in a buccal dehiscence dog model. The CR activity was found in the aggregate consisted of sheath proteins along with a small amount of amelogenins separated from newly formed secretory enamel. The sheath proteins were purified to be homogeneous, and examined for the alkaline phosphatase (ALP) inducing activity of human periodontal ligament (HPDL) cells. Application of 17 kDa sheath protein induced ALP activity in HPDL cells. Peptides synthesized from the sheath protein sequence also showed ALP inducing activity. The 17 kDa sheath protein has cell differentiation activity.

Abstract: An animal tag comprising, a penetrating component (3) having two ear penetrating members (9) joined by a strip of intermediate material (13), a complementary component (15) having a locking portion (17) for each penetrating member, and ramp means (21) for each locking portion, wherein the arrangement is such that the ear penetrating members are designed to be passed through the ear (33) of an animal and to lock onto the locking portions to sandwich the ear in a gap (28) between the penetrating component and complementary component and the ramp means are arranged to co-operate with the skin penetrating members to vary the size of the gap whereby to provide a range of gap sizes to accommodate varying ear thicknesses and/or growth of the animal.

Abstract: We prepared a transgene comprising human HB-EGF precursor cDNA, as a diphtheria toxin receptor gene, at the downstream of an insulin promoter, and introduced this transgene into a mouse fertilized egg, to produce a transgenic mouse of the present invention. In this mouse, human HB-EGF precursors are expressed specifically in islet beta cells, and by injection of diphtheria toxin, islet beta cells are selectively destroyed, resulting in that the mouse shows diabetes two or three days after the injection. This mouse can be utilized in screening and development of new medicines and therapy protocols for diabetes.

Abstract: The present invention relates to a non-polar solvent soluble extract, polyphenol fractions therefrom and the compounds isolated from Elfvingia applanata, which shows a therapeutic activity for diabetes and diabetic complications, and a pharmaceutical composition for the treatment of diabetes and diabetic complications comprising the same.

Abstract: A planar antenna fitted with a reflector of small shape and small depth. A reflector 21 of planar shape is provided at the rear face of a radiator 20 of planar shape made of a triangular loop element. The side sections 21b on both sides of the reflector 21 are bent towards the radiator 20 and the separation .alpha.2 between the leading edges of the side sections 21b and the side edges of the radiator 20 is thereby reduced. In this way, an excellent electrical characteristic of the planar antenna 2 fitted with a reflector and can be achieved by reducing the separation D2 of the radiator 20 and reflector 21.

Abstract: There is provided an exercise machine in which resistance to movement of an actuation member, such as a handle, is provided and that resistance is able to be varied through the course of a single repetition of a series of repetitive exercises. The variation of resistance with distance along the movement path of the actuation member is, in a preferred embodiment, able to be changed by the selection and fitting of a component having a contoured surface, with which a follower means in the machine interacts to vary the resistance. There is also provided a multi-function exercise machine, that lends itself well to provision of the variable resistance feature.

Abstract: A method of installing a threaded fastener from one side of a hole through a substrate. The fastener includes a collar and a bolt having a head, a threaded tail portion and a tool engagement portion extending from the tail. The method includes: (a) engaging the tool engagement portion with a bolt engagement portion of a tool (b) passing the bolt through to the far side of the hole and supporting it there by way of the tool, (c) passing the collar through the hole while supporting it with the tool; (d) assembling the bolt and collar to form the threaded fastener having a head larger than the hole; (e) engaging a nut to tighten the fastener; and (f) detaching the tool from the fastener. Separation of the bolt engagement portion and the tool engagement portion is prevented by a moveable member, which engages both portions.

Abstract: The present invention relates to a processing method for preparing pharmacologically potent ginseng product and the extract therefrom which could provide abundant amount ginsenoside Rg5 showing various pharmacological activities with applying selected range of pressure and temperature into the method and therefore the composition comprising the processed ginseng and the extract thereof can be useful as a medicament or health care food in the prevention or treatment of various diseases, especially, cancer disease.

Abstract: The circuit monitoring device is disclosed. The device is for monitoring circuit resistance. At configurable thresholds digital flags are triggered, the device can be used as a Security/Building management system. The device uses open technology is fully scaleable and allows programmable logic controllers to be used as security management systems. Using a soft logic option a PC could take the place of the PLC.

Abstract: The collection of aquatic animal eggs during hatchery production is a critical step in the successful rearing of these animals. Currently, the equipment and culture methods do not allow large numbers of animals to be spawned at the same time without several people handling the process. The disclosed invention solves the problem of collecting large quantities of released aquatic animal eggs after spawning many adults at the same time. The apparatus is simple to build, maintain, and repair, and the method of its use requires only one person to handle the spawning of many adults.

Abstract: An object of the present invention is to provide a simple, reasonably-priced patch antenna which can be assembled easily. A pair of first L-shaped holding portions 14b formed on a spacer 14 is inserted into a pair of attachment holes 12c formed in an antenna plate 12, and the antenna plate 12 is slid so that the upper portions of the attachment holes 12c in the antenna plate 12 are gripped between the upper portions of the first L-shaped holding portions 14b and a spacer main body 14a. As a result, the antenna plate 12 is fixed to the spacer 14. Next, a pair of second L-shaped holding portions 14e is inserted into a pair of insertion holes 13d formed in a ground plate 13, and the ground plate 13 is slid so that the lower portions of the insertion holes 13d in the ground plate 13 are gripped between the upper portions of the second L-shaped holding portions 14e and the spacer main body 14a. As a result, the ground plate 13 is fixed to the spacer 14.

Abstract: A combustion engine comprising; a pair of opposed cylinder elements (2, 3) having a common axis, each cylinder element being provided with a piston (28) reciprocable between first and second locations in the cylinder element the first and second locations respectively representing compression and expansion elements of the piston stroke, each piston having a forward side and a rear side; a combustion chamber (38) for each cylinder element comprising the forward side of the piston (28) and the walls (2) of the cylinder element; combustible gas compression means (37b, 37c) for each combustion chamber; supply passage means (41) arranged to deliver combustible gas to each combustible gas compression means; an induction chamber (37a) for each piston arranged to receive compressed combustible gas from the combustible gas compression means; transfer passage means (39) for directing compressed gas from each induction chamber to the respective combustion chamber, and cam means (13) rotatable about the common axis the c

Abstract: With the object of forming a compact antenna that operates in a plurality of frequency bands, the pattern of an antenna element (14) that can resonate in a plurality of frequency bands is formed on the outer circumferential surface of an antenna bobbin (12). A parasitic conductor (11) is inserted into an accommodating hole, which is formed substantially along the central axis of this antenna bobbin (12). As a result, an antenna that operates favorably in the frequency bands of AMPS, PCS and GPS can be obtained.

Abstract: An object of the present invention is a small composite antenna that is capable of operating in a plurality of different frequency bands. A first antenna 2 constituting a GPS circularly polarized loop antenna is formed on a dielectric substrate 10. A second antenna 3 constituting an ETC square patch antenna is formed on substantially the same axis as the first antenna 2. An earth pattern is formed in the underside of the dielectric substrate 10, and a recess in whose bottom face an earth pattern is formed so as to lie opposite the second antenna 3 is provided. An arc-shaped feed pattern 4 is electromagnetically coupled to the first antenna 2 so as to supply electricity thereto, whereby this antenna is made to operate as a right-handed circularly polarized antenna. Electricity is supplied by a coaxial cable to the second antenna 3 to cause same to operate as a right-handed circularly polarized antenna.