Abstract: The present disclosure describes devices useful for microscale fluid purification, separation, and synthesis. Such devices generally comprise a fluid membrane that separates two or more fluids flowing through plural microchannels operatively associated with the membrane. Often, the membrane is a semipermeable membrane, such as might be used with a filtration device, such as a dialyzer. Devices of the present invention can be combined with other microscale devices to make systems. For example, the devices may be coupled with one or more microchemical microfactories, one or more micromixers, one or more microheaters, etc. Examples of devices made according to the present invention included an oxygenator, a dialyzer, microheat exchangers, etc.

Abstract: Bass frequencies of audio can be dynamically boosted using various techniques and tools. The described techniques and tools can be applied separately or in combination. Bass frequencies of audio can be boosted using a linear combination of an input audio signal and output of a high-pass filter. For example, bass frequencies of audio can be boosted by applying a high-pass filter to an input audio signal to produce an output of the high-pass filter, determining a current level, determining a target gain amount, dynamically adjusting the input audio signal and the output of the high-pass filter, and combining the gain-adjusted signals to produce an output signal. A dynamic bass boost filter can comprise a high-pass filter and a dynamic boost module.

Abstract: A method for distribution of advertising that includes combining an audio data file that produces an advertising message when processed with a data file that produces a performance of a musical composition when processed. Alternatively the invention may be viewed as a method for distribution of music which includes providing a server connected to a computer network, permitting message data files to be provided for a fee paid by the party providing the message, purchasing rights to multimedia data files from owners of such rights and making available to end users data files comprising a message and a licensed multimedia file by a connection to the network server. Preferably the method provides a multimedia file that comprises a musical composition. An especially preferred embodiment provides a multimedia data file that is an MP3 file comprising a musical composition.

Abstract: An image processing system extracts parts or characteristics of interest from prepared biological samples One suitable use of the image processing system is to find biomarkers. But many other suitable uses are possible. Some components of the system include image preprocessing (data interpolation, retention time alignment, image noise filtering, background estimation, and formation of a composite image); image feature extraction (peaks, isotope groups, and charge groups); and computation of feature characteristics and expression statistics, differential expression, and non-differential expression. Outputs of the system include a candidate list of parts or characteristic of interest for aiding further discovery.

Abstract: We describe modified growth hormone fusion proteins and dimers comprising said fusion proteins; nucleic acid molecules encoding said proteins and methods of treatment that use said proteins in the treatment of conditions that result from growth hormone excess.

Abstract: In certain embodiments, overlap operators are applied during encoding and/or decoding of digital media, where the overlap operators have reduced DC gain mismatch and/or DC leakage between interior overlap operators and overlap operators at the edge and/or corner. In other embodiments, information indicating a selected tile boundary option for overlap processing can be encoded and/or decoded. The selected tile boundary option indicates one of a hard tile boundary option and a soft tile boundary option for processing with overlap operators. Overlap transform processing can then be applied based at least in part on the selected tile boundary option.

Abstract: The present invention features methods of treating a mammalian subject having renal cancer by administration of 4-[bis[2-[(methylsulfonyl)oxy]ethyl]amino]-benzaldehyde. The present invention further features administration protocols and dosing schedules for methods of treating patients having renal cancer and pharmaceutical compositions suitable for use in the treatment methods provided herein.

Abstract: A microfluidic separation system, which comprises a magnetic separator, which itself comprises a magnetic energy source; first and second magnetically conductive members leading from the magnetic energy source and having respective terminal ends that are separated by a gap over which a magnetic field is applied due to the magnetic energy source. The separation system further comprises a microfluidic chip for insertion into the gap, which comprises a body defining channels on respective faces of the body; and an exterior lining that seals the plurality of channels to allow separate test sample volumes to circulate in at least two of the channels. Upon insertion of the chip into the gap, a first test sample volume is confined to circulating closer to the terminal end of the first member and a second test sample volume is confined to circulating closer to the terminal end of the second member.

Abstract: Method for making lignocellulosic composites by adhering lignocellulosic substrates together. A first variant of the method involves using an adhesive composition that comprises a reaction product of (i) first ingredient selected from a soy protein or lignin and (ii) at least one substantially formaldehyde-free curing agent that includes at least one amine, amide, imine, imide, or nitrogen-containing heterocyclic functional group that can react with at least one functional group of the soy protein. A second variant of the method involves using an adhesive composition that comprises a reaction product of (i) a protein or lignin, (ii) a first compound that includes at least one amine, amide, imine, imide or nitrogen-containing heterocyclic functional group that can react with at least one functional group of the protein and (iii) a curing agent.

Abstract: Described herein are methods and systems for providing software development services in a networked software development environment. For instance, instead of performing compilation on a stand-alone desktop computer, software development activities including, compilation are performed by a service provider in response to a general query from a client requester. Such a network desirably has a global view of the source files being processed by various software development tools associated therewith. This global view enables many interesting approaches including the ability to perform analysis and optimizations to the input files not specified by the client requester. Such anticipatory processing may be based on the history and pattern of previous requests and availability of software development tools that the client requester is not aware of, for instance.

Abstract: The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, are therapeutically useful.

Abstract: Stabilized forms of gp120 polypeptide, nucleic acids encoding these stabilized forms, vectors comprising these nucleic acids, and methods of using these polypeptides, nucleic acids, vectors and host cells are disclosed. Crystal structures and computer systems including atomic coordinates for stabilized forms of gp120, and gp120 with an extended V3 loop, and methods of using these structures and computer systems are also disclosed.

Abstract: Novel systems and methods for remotely detecting at least one constituent of a gas via infrared detection are provided. A system includes at least one extended source of broadband infrared radiation and a spectrally sensitive receiver positioned remotely from the source. The source and the receiver are oriented such that a surface of the source is in the field of view of the receiver. The source includes a heating component thermally coupled to the surface, and the heating component is configured to heat the surface to a temperature above ambient temperature. The receiver is operable to collect spectral infrared absorption data representative of a gas present between the source and the receiver. The invention advantageously overcomes significant difficulties associated with active infrared detection techniques known in the art, and provides an infrared detection technique with a much greater sensitivity than passive infrared detection techniques known in the art.

Abstract: A method can include allowing a user to place a first wiring harness design component within a wiring harness topology in a wiring harness design workspace, allowing the user to place a first plurality of ground devices within the first wiring harness design component placed in the wiring harness topology, allowing the user to request an automatic ground combination, and, in response to the user requesting an automatic ground combination, automatically applying at least one electronically stored ground combination rule to a first set of ground devices comprising a plurality of the first plurality of ground devices and automatically combining at least two of the first set of ground devices into a first combined ground device based at least in part on the applied at least one electronically stored ground combination rule.

Abstract: One or more portions of the design (e.g., components, channels, or portions thereof) can be assigned instances of one or more component power domains (CPDs). Assigning an instance of a CPD to a design element (or to a portion thereof) can indicate, for example, whether the element can be switched on and off, or whether the element can operate over a range of voltages. The CPD instances can, in turn, be assigned to one or more design power domains (DPDs). Assignments of a CPD to a DPD can be evaluated according to a set of compatibility rules. Two or more electronic design elements can be connected by one or more signal paths. Organizing the CPD instances into DPDs can aid in finding signal paths that cross from a first DPD to a second DPD. To improve the reliability of signal paths traversing a DPD boundary, one or more power domain interface (PDI) components can be created to handle the signal paths at the boundary.

Abstract: A video encoding system encodes video streams for multiple bit rate video streaming using an approach that permits the encoded resolution to vary based, at least in part, on motion complexity. The video encoding system dynamically decides an encoding resolution for segments of the multiple bit rate video streams that varies with video complexity so as to achieve a better visual experience for multiple bit rate streaming. Motion complexity may be considered separately, or along with spatial complexity, in making the resolution decision.

Abstract: A new and distinct Echinacea plant named ‘Now Cheesier’ characterized by large yellow orange inflorescences, a medium habit with good branching, strong stems, and excellent vigor.

Abstract: A new and distinct Echinacea plant named ‘Secret Lust’ characterized by enlarged disc florets forming an anemone-type inflorescence, soft red orange ray florets contrasting strongly with the deep red orange disc florets, a medium habit with excellent branching, strong stems, and excellent vigor.

Abstract: A new and distinct Echinacea plant named ‘Secret Desire’ characterized by enlarged disc florets forming an anemone-type inflorescence, very large inflorescences, ray and disc florets a two-toned pink and soft orange color, a medium sized, upright habit with good branching, and excellent vigor.

Abstract: A new and distinct Echinacea plant named ‘Daydream’ characterized by large butter yellow inflorescences, a medium habit with good branching, numerous strong stems, and excellent vigor.