Abstract: An integral aortic arch infusion clamp catheter (10, 90) suited to occlude the ascending aorta, infuse blood, and deliver cardioplegia solution on opposing sides of an inflated balloon (56). The catheter has a unique balloon (102) filled with a modular resilient material to permit further expansion and adaptation to irregular surfaces and diameters of body passageways. The inflatable balloon (56) is provided closely proximate the distal end (54) of catheter (10, 90). In a first embodiment, the catheter (10) has three lumens (60,70 and 80), one lumen (60) for inflating balloon (56), a second larger lumen (70) which is large enough to infuse blood out distal opening (72), and a third lumen (80) for delivering cardioplegia solution to proximal openings (82) adjacent balloon (56). In a catheter (90) according to a second embodiment, the third lumen (80) is significantly larger than the first lumen (60) and second lumen (70) such that the lumen can be oriented downwardly in the ascending aorta.