Abstract: The invention relates to the identification of a naturally occurring internal proteolytic cleavage site in the ApoA1 protein, which leads to inactivation of the mature protein. Specific modification of this cleavage site leads to a stabilised ApoA1 protein, which is beneficial for the reverse cholesterol transport. The invention therefore encompasses pharmaceutical compositions comprising a recombinant stabilised variant ApoA1 protein or rHDL particles comprising such a protein, for use in the treatment of patients having reduced HDL or hampered reverse cholesterol transport.

Abstract: Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system replaces some or the entire data stream continually or intermittently including signal estimation methods that particularly address transient signal artifacts. The system is also capable of detecting the severity of the signal artifacts and selectively applying one or more signal estimation algorithm factors responsive to the severity of the signal artifacts, which includes selectively applying distinct sets of parameters to a signal estimation algorithm or selectively applying distinct signal estimation algorithms.

Abstract: A water vapor plasma generating apparatus which is able to generate water vapor plasma stably is provided. By applying the water vapor plasma generated by the apparatus to an object to be treated, a sterilization and disinfection treatment can be performed. In addition, by applying the water vapor plasma generated by the apparatus to a substance containing an oily ingredient, an antioxidative treatment can be performed.

Abstract: A system and method for management and processing of resource requests is provided. A content delivery network service provider determines a class associated with a set of client computing devices and monitors resources requests for the determined class. The content delivery network service provider then identifies at least one cache component for providing additional content, such as advertisement content or other additional content provided in anticipation of future resource requests, to client computing devices as a function of the determined class. In other embodiments, instead of cache components, the content delivery network service provider identifies a second set of client computing devices as a function of the determined class for providing the additional content information.

Abstract: Methods for forming a semiconductor device include forming self-aligned trenches, in which a first set of trenches is used to align a second set of trenches. Methods taught herein can be used as a pitch doubling technique, and may therefore enhance device integration. Further, employing a very thin CMP stop layer, and recessing surrounding materials by about an equal amount to the thickness of the CMP stop layer, provides improved planarity at the surface of the device.

Abstract: An identity migration program provides interfaces for a user to manage operations for migrating locally-managed identities to centrally-managed identities. The provided interfaces include a project management interface, an identity selection interface, a migration rule editor interface, and a project scheduling interface. In certain embodiments, the identity migration program includes a communication module that provides interfaces for managing communication between the identity migration program and locally-managed and centrally-managed servers. Interfaces may also be provided to manage identity group migration and migration error resolution. A migration process management interface enables the user to halt, roll back, or resume a migration project.

Abstract: According to one embodiment, when forming first, second, and third stampers by transferring three-dimensional patterns of a master, a height adjusting layer having a film thickness greater on the upper surface of a projection than on the bottom surface of a recess is formed between the second stamper and a second release layer, and the surface of the third stamper is etched with an acidic solution having a pH of less than 3.

Abstract: A mobile terminal keyboard comprises a keyboard body and a key, where sidewalls of the key can produce a cavity so as to form a capsule structure. The keyboard body and the sidewalls can be made of a transparent material; and transparent liquid can be included in the cavity. The mobile terminal keyboard can be convenient for a user and humanized. Light can pass through the transparent liquid in the cavity from one or more directions and generate refraction to form a colorful effect. The liquid in the cavity also can be deformed to generate various color changes on the press of a key.

Abstract: The invention relates to an assay for determining a health state of a subject using a combination of detecting the presence of a virus and detecting the presence of a genomic target or marker indicative of a health state.

Abstract: Provided are a nano semiconductor sheet, a thin film transistor (TFT) using the nano semiconductor sheet, and a flat panel display using nano semiconductor sheet. The nano semiconductor sheet has excellent characteristics, can be manufactured at room temperature, and has good flexibility. The nano semiconductor sheet includes: a first film and a second film disposed on at least one side of or inside of the first film, and includes a plurality of nano particles arranged substantially in parallel to each other. In addition, provided are a method of manufacturing a nano semiconductor sheet and methods of manufacturing a TFT and a flat panel display using the nano semiconductor sheet. The method of manufacturing a nano semiconductor sheet, includes: forming first polymer micro-fibers having a plurality of nano particles arranged substantially in parallel; preparing a first film; and arranging a plurality of the first micro-fibers on at least one side of or inside of the first film.

Abstract: The invention provides a novel chemical series of formula I, as well as methods of use thereof for binding to the benzodiazepine site of the GABAA receptor and modulating GABAA, and use of the compound of formula I for the treatment of GABAA receptor associated disorders. The general structure of formula I is shown below: The invention further provides a method of modulation of one or more GABAA subtypes in an animal comprising administering to the animal an effective amount of a compound of formula (I).

Abstract: According to one embodiment, there is provided a control block including a read control processor for reading designated content, a time information processor for processing time information. A controller returns, to a user terminal, a response signal, and information indicating a second absolute time point when an operation is executed in response to a request signal generated by the user terminal at a first absolute time point. The controller stores time difference information indicating a time difference between the first and the second absolute time points. When responding to a further request signal sent from the requester via the network, the controller sets, as tag time information, time information obtained by correcting, using the time difference information, a current relative time period for which the designated content is read.

Abstract: A reflection-detector sensor position indicator comprises emitters that transmit light having a plurality of wavelengths. A detector outputs a sensor signal. At least one reflection detector outputs at least one sensor position signal. An attachment assembly attaches the emitters, the detector and the reflection detector onto a tissue site. A sensor-on condition indicates that the attachment assembly has positioned the emitters generally centered over a fingernail, the detector on a fingertip opposite the fingernail and the reflection detector over the fingernail. The sensor signal, in the sensor-on condition, is at least substantially responsive to the emitter transmitted light after attenuation by pulsatile blood flow perfused within a fingernail bed underneath the fingernail. The sensor position signal, in the sensor-on condition, is at least substantially responsive to the emitter transmitted light after reflection off of the fingernail.

Abstract: A system and method are provided for verifying data copies and reverifying the copies over the life span of media according to a verification policy. Characteristics of media and use of media are tracked to provide metrics which may be used to dynamically reevaluate and reassign verification policies to optimize media usage. Copies that fail verification operations may be repaired by repeating a storage operation for recent copies or by substituting a close temporal copy of the failed copy.

Abstract: A fuel cell system including: a reformer to convert a fuel into hydrogen; a reformer chamber to contain air heated by the reformer; a fuel cell stack to convert the hydrogen into electricity; a first pump to supply an oxidant to the stack; and a second pump to supply the heated air to the stack, to preheat the stack. The system may also include a controller to control the operation of the system, such that the heated air is not supplied until it reaches a predetermined temperature, and the oxidant is not supplied and the stack is not operated, until the stack reaches a predetermined temperature.

Abstract: Methods and devices for applying bias potentials of opposite polarities to columns of electromechanical display elements are described herein. The bias potentials may be applied such that a column and an adjacent column receive bias potentials of opposite polarity. The bias potentials may be applied such that a polarity of bias voltages received by columns of a first set of the display elements is opposite a polarity of bias voltages received by columns of a second set of the display elements.

Abstract: A continuous wave Raman laser for producing visible laser output comprising: a resonator cavity; at least a first reflector and a second reflector said first and second reflectors being located at opposite ends of the resonator cavity; a laser gain medium located in the resonator cavity for generating a continuous wave fundamental beam which resonates within the resonator cavity when pumped by a pump beam from a pump source external to the resonator cavity; a solid Raman-active medium positioned in the resonator cavity for Raman shifting the fundamental beam to produce a continuous wave Raman beam which resonates within the resonator cavity; and a non-linear medium positioned in the resonator cavity for frequency converting the continuous wave Raman beam to a converted wavelength to produce a continuous wave converted beam.

Abstract: Systems and methods are disclosed for monitoring and managing data transactions, such as SQL transactions. In certain examples, a management subsystem generates an alert identifying degrading database transactions to facilitate preventative tuning or other maintenance. In particular, a monitor module tracks performance measurements (e.g., logical reads) of select transactions. A modeler correlates the performance measurements and assigns first performance model(s) to represent the performance measurements and predicted performance measurements of a particular transaction. A trend change module detects a significant change in a trend and/or variance of the performance measurements and can cause the modeler module to generate a second performance model to represent at least a portion of the performance measurements and the predicted performance measurements of the particular transaction.

Abstract: Optimizing a wireless power system by separately optimizing received power and efficiency. Either one or both of received power and/or efficiency can be optimized in a way that maintains the values to maximize transferred power.

Abstract: A solar concentrator assembly is disclosed. The solar concentrator assembly comprises a first reflective device having a first reflective front side and a first rear side, a second reflective device having a second reflective front side and a second rear side, the second reflective device positioned such that the first reflective front side faces the second rear side, and a support assembly coupled to and supporting the first and second reflective devices, the second reflective device positioned to be vertically offset from the first reflective device.