Abstract: A percutaneous absorptive anesthetic is provided, wherein said anesthetic is formed by mixing a base agent of said anesthetic with one or two type of mixtures which has/have been selected from the groups, for example made of glycyrrhizin, glycyrrhetic acid, glycyrrhetic acid derivatives glycyrrhetic acid 3.beta.-monohemisuccinate, glycyrrhetic acid 3.beta.-monohemisuccinate, 18.beta.-olean-12-ene-3.beta., 30-dihemiphthalate, 18.beta.-olean-9, (11)12-diene-3.beta., 30-diol-dihemiphthalate, olean-11,13(18)-diene-3.beta., 30-diol-dihemiphthalate or their pharmaceutically allowable salt.