Abstract: A shoe sole particularly for athletic footwear for supporting the foot of an intended wearer having multiple rounded portions formed by midsole component as viewed in a frontal plane of the sole when the shoe sole is upright and in an unloaded condition. The rounded portions approximate the structure of and support provided by features of the human foot. The rounded portions are located proximate to important structural support areas of an intended wearer's foot on either or both sides of the shoe sole or the middle portion of the shoe sole, or at various combinations of these locations. The midsole component also includes an indentation in the sole midtarasal portion, as viewed in a sagittal plane, and midsole component extends into a sidemost section of the sole and above a lowermost point of the midsole component, as viewed in a frontal plane cross-section when the shoe sole is upright and in an uploaded condition.