Abstract: A polyaxial screw assembly includes an internal load dampening mechanism for sharing and dampening loads between at least one screw member and at least one rod member interconnected by the assembly. A method of interconnecting the orthopedic screw with the rod includes dampening with a body member interconnecting the screw to the rod.

Abstract: A bone screw includes a head portion and shank portion. The shank portion includes a regularly outwardly expanding threaded portion.

Abstract: A molecular fan for dissipating heat, the fan having a chemically functionalized molecular fan thin film coating affixed to a surface in need of heat dissipation. A nanocoating for dissipating heat, the coating having a thin film coating affixed to a surface in need of heat dissipation. A molecular fan thin film coating affixed to a surface in need of heat dissipation for dissipating heat.

Abstract: There is provided a diagnostic tool for use in diagnosing diseases, the tool having a detector for detecting the presence of an array of markers indicative of disease. Also provided is a combination of markers for disease, the combination including at least two markers of the disease. A method of choosing such combinations of markers for a given disease as well as a method for detecting a combination of markers for diagnosing the presence of a disease state or determining a disease stage is also provided. The method includes selectively biopanning sera obtained from a patient to obtain cDNA clones to array for analysis and determining if the markers are present among the cDNA clones present in the disease. Epitopes found using this method are also provided as well as a database incorporating these epitopes. A biochip for detecting the presence of a disease marker in a patient's sera is provided, wherein the biochip has a detector contained within the biochip for detecting disease markers in a patient's sera.

Abstract: A new group of picornaviruses is disclosed. The picornaviruses of the invention comprise in the non-coding region of their viral genome a nucleotide sequence which corresponds to cDNA sequence (I) or homologous sequences having at least 75% homology to the SEQ ID NO:1, and they cause mammalian disease. Further aspects of the invention comprise a protein corresponding to a protein of the picornaviruses, antiserum or antibody directed against a protein of the picornaviruses, antigen comprising a protein of the picornaviruses, diagnostic kits, vaccines, use of the picornaviruses in medicaments, particularly for the treatment or prevention of Myocarditis, Cardiomyopathia, Guillain Barré Syndrome, and Diabetes Mellitus, Multiple Sclerosis, Chronic Fatigue Syndrome, Myasthenia Gravis, Amyothrophic Lateral Sclerosis, Dermatomyositis, Polymyositis, Spontaneous Abortion, and Sudden Infant Death Syndrome, and methods of treatment of diseases caused by the picornaviruses.

Abstract: Disclosed is an immunogenic hybrid polypeptide comprising a mimetic peptide of a B cell epitope of apolipoprotein B-100 and a helper T cell epitope, the mimetic peptide being fused at its C-terminus to an N-terminus of the helper T cell epitope. Also disclosed is a vaccine composition for preventing or treating obesity comprising the polypeptide.

Abstract: A method of inhibiting protein kinases by administering polypeptides derived from alpha-neurotoxin, and inhibiting protein kinases. Diseases treated thereby include cancer, influenza, Tourette's syndrome, pain, and neurological deficits.

Abstract: A fuzzy inference system for use in modulating radiation treatment includes a fuzzifer for inputting imaging data, and inference device operatively to the fuzzifer for analyzing the imaging data and determining radiation treatment target from non-treatment target, and a defuzzifier for modulating radiation treatment pursuant to the analysis from the inference device.

Abstract: The present invention relates to a method for specifically detecting Ljungan virus (LV). In particular, the present invention relates to a method of detecting LV using quantitative real-time reverse transcriptase PCR. The present invention also provides kits for performing the method of the invention.

Abstract: At least one electric discharge lamp capable of generating a broadband output pulse of a range of wavelengths in the visible spectrum, the output pulse having a predetermined time interval and a predetermined total electrical energy input for the pulse, has a drive circuit for delivering energy pulses to the electrical discharge lamp, as well as a sensor for sensing an optical output from the discharge lamp; and a control mechanism for operating the drive circuit in response to variations in optical output detected by the sensor.

Abstract: A method of treating amyloidoses by administering an effective amount of a cystatin C composition. A method of preventing and inhibiting A? oligomerization by administering an effective amount of a cystatin C composition. A composition for inhibiting A? oligomerization including an effective amount of a cystatin C composition. A method of diagnosing disease by assaying for a biomarker comprising a cystatin C complex. A biomarker for disease including a cystatin C complex.

Abstract: A compound consists of a fractal-like, plain or organometallic array useful for energy storage devices. A dendrimer useful in the synthesis of the fractal-like compound includes a single ligating moiety bound to a surface of each quadrant of the dendrimer. A method of making metallo-based (macro) molecules includes the steps of combining monomers selected from the group consisting of bipyridal- and terpyridal-based ligands with connecting metals and self assembling macrocycles wherein the monomes are interconnected by the metals.

Abstract: An emulsion for preparing a low-conductivity surface for powder coating, the emulsion including an emulsified organofunctional silane solution. A pre-powder coating emulsion provides a surface with conductivity. A non-conductive object having applied to an exterior surface of the object the emulsion including an emulsified organofunctional silane solution.

Abstract: A method for overcoming immune suppression includes the steps of inducing production of naïve T cells and restoring T cell immunity. A method of vaccine immunotherapy includes the steps of inducing production of naïve T cells and exposing the naïve T cells to endogenous or exogenous antigens at an appropriate site. Additionally, a method for unblocking immunization at a regional lymph node includes the steps of promoting differentiation and maturation of immature dendritic cells at a regional lymph node and allowing presentation of processed peptides by resulting mature dendritic cells, thus, for example, exposing tumor peptides to T cells to gain immunization of the T cells.

Abstract: A flashlamp drive circuit including a storage capacitor which is charged and selectively discharged in order to drive a flashlamp. A capacitor (116) is connected in parallel with each respective flashlamp (106) in a bank of flashlamps. Each capacitor (116) has a comparatively small capacitance so as to be capable of storing only a portion of the total energy pulse required to be delivered to the respective flashlamp (106). A controller, comprising a digital signal processor (118) and a microprocessor (120) is provided to control the operation of all of the flashlamps (106) in the bank via respective switch mechanisms (110). In use, each energy (or drive) pulse delivered to a flashlamp (106) is comprised of a plurality of smaller energy packets resulting from repeated charging and discharging of the respective capacitor (116).

Abstract: A method to assess arachidonic acid (AA) metabolites-dependent hypertension by measuring glucuronidated dihydroxyeicosatrienoic acids (DHETs) and DHET metabolites in a biological sample which contains the epitopes unique to DHET (using any methods including GC/MS, LC/MS or ELISA) is disclosed. An example of the glucuronidated DHET metabolite is DHET-alcohols such as omega or omega-1 oxidated DHET and DHET esterified glycerol. The method further includes determining the amount of glucuronidated molecules containing a DHET-specific epitope which is immunoreactive with antibodies produced against DHETs. The present invention measuring glucuronidated DHET levels in a biological sample is useful for drug development and monitoring efficiency of drug treatment of a mammal who has AA epoxygenase-, epoxide hydrolase-and/or UDP-glucuronosyl transferase-dependent hypertension.

Abstract: A lubricant includes a hydrocarbon end group of the formula alkyl-phenol-alkylene oxide-Y wherein Y is the hydrocarbon end group; and wherein the polyalkylene glycol has the formula Z((CH2CH(R1)O)n(CH2CH(R1)O)m)pH wherein Z is a residue of an aryl compound having 1-8 active hydrogens and at least 10 carbons when Z is an aryl group; R1 is hydrogen, methyl, ethyl, or a mixture thereof; n is 0 or a positive number; m is a positive number; and p is an integer having a value equal to the number of active hydrogens, the compound of which Z is a residue, Y replacing the H. A fluid composition for use in refrigeration systems including the lubricant and a refrigerant. A method of lubricating compression refrigeration equipment The lubricant used as a seal swell additive, an additive for compressor and machinery applications, a mineral oil pour point improver, a machinery cleanser, and a carbon dioxide additive.

Abstract: A wrist-mounted device for measuring at least one physiological parameter of a subject. The present invention enables such a measurement to preferably be transformed into clinically useful information about the subject. Such information may then optionally be sent to medical personnel, for example at a contact and/or monitoring center, through a gateway device. The gateway device preferably communicates with the wrist-mounted device of the present invention through a wireless communication channel.