Abstract: Artificial implants having reduced area to provide reduced wear are provided. The reduced area is particularly located at areas where greatest wear is exhibited. In a particular embodiment of a mobile bearing knee implant, the area is reduced on the mobile bearing insert underside, where it contacts a tibial component. The reduced area may be any shape of indentations, for example, grooves, dimples, straight patterns, curved patterns, crossing patterns, holes, channels or slots. The indentations may be various sizes, and have been found to be particularly effective if covering about 10% to about 20% of the insert at depths between about 1-2 mm.

Abstract: A nematode dopamine tansporter cDNA has been cloned, sequenced, and expressed, and provides a convenient screening assay for antiparasitics, as well as psychoactive drugs.

Abstract: A feedthrough device having a ground wire that is coupled to both a metallic ferrule and to an insulating material and methods of making the device are provided. The ground wire is coupled or brazed between, adjacent to, or otherwise in direct contact with the metallic ferrule and the insulating material, for example, in a gap between the insulating material and the ferrule, or directly to the side of the insulating material and abutting the surface of the ferrule. If the ground wire is coupled or brazed in a gap, the gap may be formed by a notch in either the insulating material, the ferrule or both.

Abstract: An underlayment material is disclosed for use as an underlayment in a non-textile flooring system. The underlayment material comprises a thin, flexible layer of polyurethane foam and a thin, flexible substrate layer bonded to one side of the layer of polyurethane foam. In a preferred embodiment, the underlayment material is a mechanically frothed polyurethane foam. In another preferred embodiment, the substrate layer is a layer of non-woven spun bonded polyester fibers. In another preferred embodiment, the underlayment material has a thickness of between about 0.05 and 0.125 inches, and most preferably, about 0.085 inches. In still another preferred embodiment, the foam has a fine cell structure and a density of between 10 and 30 pounds per cubic foot, and most preferably about 20 pounds per cubic foot. In still another preferred embodiment, the foam has a compression set of between about 5% and 25%, and most preferably about 10%.

Abstract: Fibrointimal proliferation, neointimal hyperplasia and other vascular lesions or injuries are reduced by ex vivo irradiation of the autologous coronary bypass conduit, especially the saphenous vein, as an adjunct in cardiovascular surgery or other treatment, in anyone of a variety of suitable devices.

Abstract: A multilayer brazeable metallization structure for diamond components is described. The brazeable metallization finds particular application for the attachment of diamond components such as heat spreaders in electronic packages that incorporate high power semiconductor devices. In the present invention, a diamond component is provided with a multilayer coating of metals including a first layer of chromium for adhesion, a second barrier layer of a refractory metal for a barrier that may be alloyed with chromium, and a top layer of copper, silver or gold for wetting. The refractory metals for the second layer include tungsten, molybdenum, tantalum and niobium. Tungsten or tungsten-chromium alloy is preferred as the second layer. This multilayer metallization structure provides a robust interface between diamond and standard brazing alloys which are used to join the diamond to electrical leads or a flange made of metals such as copper-tungsten.

Abstract: Fibrointimal proliferation, neointimal hyperplasia and other vascular lesions or injuries are reduced by ex vivo irradiation of the autologous coronary bypass conduit, especially the saphenous vein, as an adjunct in cardiovascular surgery or other treatment, in anyone of a variety of suitable devices.

Abstract: A thread guiding wheel for use in textile machinery has a circumferential slot (8) adapted to receive a given yarn; the circumferential slot is generally V-shaped in section, having axially opposed walls (6, 7) which, in a radially inwards direction, converge to a base at which the walls intersect, the base of the V being sufficiently sharp to grip, between the axially opposed walls, a part of said yarn extending about at least a part of the circumference of the wheel.

Abstract: Three-dimensional structures are preferably formed of folded printed material which becomes three-dimensional and exhibits a shadowbox effect when in the open position, but which remains substantially two-dimensional when closed. The structures are formed from a base sheet having a plurality of fold-lines that define a plurality of panels. Two panels are hinged and may be opened to display one or more tiers, which are defined by additional panels. Optionally, one or more panels may have cutout sections, particularly the panels forming the tiers, thereby providing a tiered shadowbox effect.

Abstract: Support systems for vessels such as above-ground swimming pools are disclosed. Each system may include one or more buttresses adapted to support substantially the entire vertical height of the side wall or each of a series of side walls of the pool. A strapless support system to provide a pool having a deep end is also disclosed. The buttresses, which flare along their lengths, closely match the support they provide each side wall to the outward water pressure present along its height for enhanced reliability. The diminished space required for installation of the disclosed buttresses reduces the surface area required for their associated pool.

Abstract: Compounds such as formula (I) are useful in the treatment of tumor cells and the treatment of cancer.

Abstract: Novel calcium phosphate core particles, methods of making them, and methods of using them as vaccine adjuvants, as cores, as carriers of biologically active material, and as controlled release matrices for biologically active material are disclosed. The core particles may have a surface modifying agent and/or biologically active material, such as antigenic material or natural immunoenhancing factor, polynucleotide material, or therapeutic proteins or peptides, partially coating the particle or impregnated therein. The core particles have a diameter between about 300 nm and about 4000 nm, more particularly between about 300 nm and about 2000 nm, and even more particularly between about 300 nm and about 1000 nm, are substantially spherical in shape, and have a substantially smooth surface.

Abstract: A system consisting of an accelerometer sensor attached to a centrifuge enclosure for sensing vibrations and outputting a signal in the form of a sine wave with an amplitude and frequency that is passed through a pre-amp to convert it to a voltage signal, a low pass filter for removing extraneous noise, an A/D converter and a processor and algorithm for operating on the signal, whereby the algorithm interprets the amplitude and frequency associated with the signal and once an amplitude threshold has been exceeded the algorithm begins to count cycles during a predetermined time period and if a given number of complete cycles exceeds the frequency threshold during the predetermined time period, the system shuts down the centrifuge.

Abstract: The present invention relates to vitrification of ion exchange resins that have become loaded with hazardous or radioactive wastes, in a way that produces a homogenous and durable waste form and reduces the disposal volume of the resin. The methods of the present invention involve directly adding borosilicate glass formers and an oxidizer to the ion exchange resin and heating the mixture at sufficient temperature to produce homogeneous glass.

Abstract: A method for detecting the presence of a target nucleic acid sequence in a sample is provided. The method comprises subjecting the sample to an amplification reaction to obtain an amplification product where the target nucleic acid sequence is present using a set of nucleotides, at least one of which is fluorescently labelled. The amplification product is contacted with a probe under conditions in which the probe will hybridise to the target sequence. The probe comprises a reactive molecule which is capable of absorbing fluorescence energy from or donating fluorescent energy to the fluorescent labelled nucleotide. The fluorescence of the sample is monitored and related to the presence of the target nucleic acid sequence. The method can be used to quantitate the amount of target nucleic acid in the sample as well as to determine sequence characteristics. Kits for effecting the method are also provided.

Abstract: The present invention relates to a storage device for use with a carrying case, and having an aperture therein adapted to receive a handle or strap of the carrying case. The device may also have attachment devices enabling the device to be carried separate from the carrying case if desired. Side body portions of the device have compartments that are adapted to receive, store, and carry items of various sizes. These compartments may be lined with material to protect or enhance the items contained therein. Optional straps may extend from the bottom edges of the side portions in order to attach and secure the device onto a carrying case.

Abstract: A modular humeral prosthesis for replacement of the humeral head of a humerus. The prosthesis generally comprises a stem to be fitted to a resected humerus; a head sized and configured to approximate the humeral head; and an intermediate connecting member for connecting the stem to the head. A first engagement/mounting portion is provided on the intermediate connecting member for mounting the intermediate connecting member on the stem, and a second engagement/mounting portion is provided on the intermediate connecting member for mounting the head on the intermediate connecting member. The first engagement/mounting portion has an axis about which the intermediate connecting member can be rotated through 360° relative to the stem and thereafter secured at a selected relative orientation. The second engagement/mounting portion has an axis about which the head can be rotated through 360° relative to the intermediate connecting member and thereafter secured at a selected relative rotation.

Abstract: The present invention relates to methods for separating casein from milk, and for separating from milk proteins that can be associated or entrained within casein micelles, by contacting the milk with a chelating agent to disrupt the casein micelles and reconstituting the micelles by introducing small insoluble inorganic particles.