Abstract: NAIP and IAP polypeptides prevent neuronal cell death caused by ischemia, neurodegenerative conditions, and axotomy. The invention provides methods for neuroprotection by the prevention of cell death and kits and methods for the identification of neuroprotective therapeutic compounds.
Type:
Grant
Filed:
December 11, 2000
Date of Patent:
March 23, 2004
Assignee:
Aegera Therapeutics, Inc.
Inventors:
George S. Robertson, Robert G. Korneluk, Alexander E. MacKenzie, Daigen Xu, Stephen J. Crocker