Abstract: The invention features purified nucleic acid encoding a novel internal ribosome entry site (IRES) sequence from the X-linked inhibitor of apoptosis (XIAP) gene. The invention also features methods for using the XIAP IRES to increase cap-independent translation of polypeptide coding sequences linked to the XIAP IRES, and methods for isolating compounds that modulate cap-independent translation.
Type:
Grant
Filed:
June 14, 1999
Date of Patent:
January 9, 2001
Assignee:
Apoptogen, Inc.
Inventors:
Robert G. Korneluk, Martin Holcik, Peter Liston