Patents Represented by Attorney Kristina Clark & Elbing LLP Bieker-Brady

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  • Methods for assessing the prognosis of a patient with a neurodegenerative disease
    Patent number: 6022683
    Abstract: The present invention provides a method for the determining the appropriate therapy and/or prognosis for a patient diagnosed with a non-Alzheimer's disease (AD) neurological disease based upon the patient's apoE allele load. The invention also provides a method for the identification of human subjects with a non-AD neurological disease that are likely to respond in clinical trials that test pharmaceuticals useful in the treatment of neurological diseases.
    Type: Grant
    Filed: December 16, 1996
    Date of Patent: February 8, 2000
    Assignee: Nova Molecular Inc.
    Inventor: Judes Poirier
  • Methods for the daignosis, of familial amyotrophic lateral sclerosis
    Patent number: 5843641
    Abstract: Disclosed is the family of genes responsible for the neurodegenerative diseases, particularly Amyotrophic Lateral Sclerosis. Methods and compounds for the diagnosis, prevention, and therapy of the disease are also disclosed.
    Type: Grant
    Filed: February 26, 1993
    Date of Patent: December 1, 1998
    Assignees: Massachusetts Institute of Technology, General Hospital Corporation, The
    Inventors: Robert Brown, H. Robert Horvitz, Daniel R. Rosen
  • Genetically stable cholera vaccines with deletions of ctxA, recA and attRS1
    Patent number: 5631010
    Abstract: The invention features a nontoxigenic genetically stable mutant strain of V. cholerae which lacks any functional attRS1 sequences is useful as a live, oral vaccine for inducing immunological protection against cholera and a method for making same. The invention also features a killed, oral cholera vaccine comprising at least a first and a second V. cholerae strain, wherein at least one of the strains is a different serotype, and the vaccine also contains cholera toxin B subunit, produced by at least one of the serotypes.
    Type: Grant
    Filed: March 14, 1995
    Date of Patent: May 20, 1997
    Assignee: President and Felllows of Harvard College
    Inventor: John J. Mekalanos