Patents Represented by Attorney Kyle D. Yesland
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Patent number: 7875762Abstract: This invention provides for proteins which are expressed in the avian oviduct, packaged into eggs laid by the avian and removed from the eggs.Type: GrantFiled: January 23, 2006Date of Patent: January 25, 2011Assignees: Synageva BioPharma Corp., University of Georgia Research Foundation, Inc.Inventors: Robert D. Ivarie, Alex J. Harvey, Julie A. Morris, Guodong Liu, Jeffrey C. Rapp
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Patent number: 7812215Abstract: Methods of producing protein using a recombinant ovomucoid gene expression controlling region operably linked to one or more useful amino acid coding sequences.Type: GrantFiled: November 17, 2008Date of Patent: October 12, 2010Assignee: Synageva BioPharma Corp.Inventors: Alex J. Harvey, Markley C. Leavitt, Youliang Wang
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Patent number: 7812127Abstract: The invention relates to G-CSF molecules having certain O-linked oligosaccharide structures.Type: GrantFiled: June 27, 2008Date of Patent: October 12, 2010Assignees: Synageva BioPharma Corp., University of Georgia Research FoundationInventors: Robert D. Ivarie, Alex J. Harvey, Julie A. Morris, Guodong Liu, Jeffrey C. Rapp
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Patent number: 7803362Abstract: The invention relates to interferon-? molecules having certain O-linked oligosaccharide structures.Type: GrantFiled: July 3, 2008Date of Patent: September 28, 2010Assignees: Synageva BioPharma Corp., University of GA Research FoundationInventors: Robert D. Ivarie, Alex J. Harvey, Julie A. Morris, Guodong Liu, Jeffrey C. Rapp
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Patent number: 7795496Abstract: The present invention provides for methods of producing transgenic avians which may include delivering a heterologous nucleic acid to oviduct tissue of an avian wherein the nucleic acid enters a cell of the oviduct tissue and is expressed.Type: GrantFiled: February 13, 2009Date of Patent: September 14, 2010Assignee: Synageva BioPharma Corp.Inventors: Leandro Christmann, Markley C. Leavitt, Dawn M. Eberhardt, Timalynn M. Matthews
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Patent number: 7585963Abstract: The present invention provides isolated and recombinant avian nucleic acid molecules comprising at least one avian MAR and an avian nucleic acid sequence encoding an ovalbumin transcriptional regulatory region. The isolated nucleic acid of the present invention is useful for reducing chromosomal positional effects upon the transcription of a transgene operably linked to the ovalbumin transcriptional regulatory region and transfected into a recipient avian cell The recombinant nucleic acid molecules of the present invention may further comprise a polyadenylation signal sequence or an avian 3? domain, and optionally, an internal ribosome entry site for expression of an operably linked heterologous nucleic acid insert in a transfected avian cell.Type: GrantFiled: December 11, 2003Date of Patent: September 8, 2009Assignees: Synageva BioPharma Corp., University of Georgia Research Foundation, Inc.Inventors: Markley C. Leavitt, Jeff Rapp, Robert Ivarie, Arthur Karnuah
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Patent number: 7550650Abstract: This invention provides methods for the stable introduction of heterologous coding sequences into the genome of a bird and expressing the coding sequences to produce desired proteins or to alter the phenotype of the bird. The present invention provides preferred methods for introducing a transgene into the cytoplasm of avian embryonic cells by cytoplasmic microinjection. The embryo then develops into a transgenic adult capable of expressing a heterologous protein and/or capable of generating a line of transgenic birds through breeding. Synthetic vectors and gene promoters useful in the methods are also provided by the present invention, as are transgenic birds that express heterologous protein and avian eggs containing heterologous protein.Type: GrantFiled: October 2, 2003Date of Patent: June 23, 2009Assignee: Synageva BioPharma Corp.Inventors: Jeffrey C. Rapp, Leandro Christmann
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Patent number: 7541512Abstract: The invention provides for transgenic avians containing nucleic acids which include an exogenous lysozyme gene expression controlling nucleotide sequence which typically is linked to a polynucleotide encoding a heterologous polypeptide.Type: GrantFiled: January 26, 2007Date of Patent: June 2, 2009Assignee: Synageva BioPharma Corp.Inventors: Jeffrey C. Rapp, Alex J. Harvey
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Patent number: 7534929Abstract: This invention provides vectors and methods for the stable introduction of exogenous nucleic acid sequences into the genome of avians in order to express the exogenous sequences to alter the phenotype of the avians or to produce desired proteins. In particular, transgenic avians are produced which express exogenous sequences in their oviducts and which deposit exogenous proteins into their eggs. Avian eggs that contain exogenous proteins are encompassed by this invention. The instant invention further provides novel forms of interferon and erythropoietin which are efficiently expressed in the oviduct of transgenic avians and deposited into avian eggs.Type: GrantFiled: April 6, 2005Date of Patent: May 19, 2009Assignees: Synageva BioPharma Corp., University of Georgia Research Foundation, Inc.Inventors: Robert D. Ivarie, Alex J. Harvey, Julie A. Morris, Guodong Liu, Jeffrey C. Rapp
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Patent number: 7524626Abstract: The invention includes methods of producing viral particles which include introducing into avian cells a nucleotide sequence encoding a replication deficient retroviral vector and introducing into the avian cells nucleotide sequences encoding products required for replication of the replication deficient retroviral vector under the control of a promoter that is functional in the avian cell line, and harvesting the viral particles.Type: GrantFiled: October 3, 2006Date of Patent: April 28, 2009Assignee: Synageva BioPharma Corp.Inventor: Alex J. Harvey
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Patent number: 7521591Abstract: This invention provides eggs which contain exogenous proteins. The invention further provides transgenic chickens which express exogenous sequences in their oviducts, and vectors and methods for the stable introduction of exogenous nucleic acid sequences into the genome of a bird for expressing said exogenous sequences to alter the phenotype of the bird or to produce desired proteins.Type: GrantFiled: October 28, 2003Date of Patent: April 21, 2009Assignees: Synageva BioPharm Corp., University of Georgia Research FoundationInventors: Robert D. Ivarie, Alex J. Harvey, Julie A. Morris, Guodong Liu
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Patent number: 7511120Abstract: Granulocyte colony stimulating factor obtained from eggs laid by transgenic avians having newly described G-CSF glycosylation patterns.Type: GrantFiled: February 20, 2007Date of Patent: March 31, 2009Assignees: Synageva BioPharma Corp., University of Georgia Research FoundationInventors: Robert D. Ivarie, Alex J. Harvey, Julie A. Morris, Guodong Liu, Jeffrey C. Rapp
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Patent number: 7507873Abstract: Transgenic avians having a recombinant ovomucoid gene expression controlling region operably linked to one or more useful amino acid coding sequences.Type: GrantFiled: January 4, 2007Date of Patent: March 24, 2009Assignee: AviGenics, Inc.Inventors: Alex J. Harvey, Markley C. Leavitt, Youliang Wang
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Patent number: 7445774Abstract: This invention provides for human interferon-? which includes novel glycosylation structures.Type: GrantFiled: February 28, 2006Date of Patent: November 4, 2008Assignees: AviGenics, Inc., University of Georgia Research Foundation, Inc.Inventors: Robert D. Ivarie, Alex J. Harvey, Julie A. Morris, Guodong Liu, Jeffrey C. Rapp
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Patent number: 7432103Abstract: The present invention relates to cells that can be passaged in culture and can be used for, among other things, promoter assays and the production of heterologous proteins.Type: GrantFiled: February 1, 2008Date of Patent: October 7, 2008Assignee: AviGentics, Inc.Inventors: Jeffrey C. Rapp, Stephen H. Parker, Markley C. Leavitt, Dawn M. Eberhardt, Leandro Christmann, Alex J. Harvey
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Patent number: 7381712Abstract: The present invention provides for methods of producing transgenic avians which may include delivering a heterologous nucleic acid to oviduct tissue of an avian wherein the nucleic acid enters a cell of the oviduct tissue and is expressed.Type: GrantFiled: May 10, 2004Date of Patent: June 3, 2008Assignee: AviGenics, Inc.Inventors: Leandro Christmann, Markley C. Leavitt, Dawn M. Eberhardt, Timalynn M. Matthews
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Patent number: 7375258Abstract: The present invention provides novel isolated nucleic acids that comprise an avian nucleic acid sequence comprising a ovomucoid gene expression control region. The ovomucoid promoter region of the present invention will allow expression of an operably linked heterologous nucleic acid insert in a transfected avian cell such as, for example, an oviduct cell. The isolated avian ovomucoid of the present invention may be operably linked with a selected nucleic acid insert, wherein the nucleic acid insert encodes a polypeptide desired to be expressed in a transfected cell. The recombinant DNA of the present invention may further comprise a polyadenylation signal sequence. The present invention further includes expression vectors comprising an isolated avian ovomucoid gene expression control region of the present invention, and transfected cells and transgenic avians comprising the expression vectors.Type: GrantFiled: December 2, 2002Date of Patent: May 20, 2008Assignee: AviGenics, Inc.Inventors: Alex J. Harvey, Youliang Wang
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Patent number: 7351582Abstract: The present invention relates to cells that can be passaged in culture and can be used for, among other things, promoter assays and the production of heterologous proteins.Type: GrantFiled: June 16, 2006Date of Patent: April 1, 2008Assignee: AviGenics, Inc.Inventors: Jeffrey C. Rapp, Stephen H. Parker, Markley C. Leavitt, Dawn M. Eberhardt, Leandro Christmann, Alex J. Harvey
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Patent number: 7338654Abstract: This invention includes compositions comprising glycosylated human interferon-? derived from a chicken.Type: GrantFiled: March 8, 2006Date of Patent: March 4, 2008Assignees: AviGenics, Inc., University of Georgia Research Foundation, Inc.Inventors: Robert D. Ivarie, Alex J. Harvey, Julie A. Morris, Guodong Liu, Jeffrey C. Rapp
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Patent number: 7339090Abstract: The present invention provides for microinjection devices comprising a needle and a viewing instrument wherein the viewing instrument provides magnified viewing of an object to an operator from an angle other than a right angle to the object.Type: GrantFiled: June 23, 2005Date of Patent: March 4, 2008Assignee: AviGenics, Inc.Inventor: Leandro Christmann