Patents Represented by Attorney L. N. Goodwin
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Patent number: 4933055Abstract: A novel method for the production of bis(arene) technetium radiodiagnostic imaging agents is herein disclosed. The method consists of employing Fischer synthesis reactants in an ultrasonic bath. The products are virtually pure, thus lacking the severe degree of disproportionation which routinely occurs when partially alkylated bis(arene)technetium compounds are produced by thermally driven reactions.Type: GrantFiled: June 17, 1987Date of Patent: June 12, 1990Assignee: Mallinckrodt, Inc.Inventor: Dennis W. Wester
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Patent number: 4849511Abstract: The invention relates to a technetium chelate of the general formula ##STR1## wherein X is a sulphur atom or an imino group,Z is a hydrogen atom, a carboxy group, an alkoxycarbonyl group having 1-4 carbon atoms, an aminocarbonyl group, a sulpho group, an aminousulphonyl group or a carboxymethylaminocarbonyl group,Tc represents technetium-99m,R.sub.1 is a hydrogen atom or an alkyl group having 1 or 2 carbon atoms, andR.sub.2, R.sub.3, R.sub.4 and R.sub.5 are equal or different and represent hydrogen atoms or branched or non-branched alkyl groups having 1-4 carbon atoms, which alkyl groups are optionally substituted with an amino group, a hydroxy group, a mercapto group, a halogen atom, a carboxy group or an aminocarbonyl group,with the proviso that R.sub.3 R.sub.4 and R.sub.5 do not all three of them represent hydrogen atoms;as well as water-soluble salts of these compounds.Type: GrantFiled: May 26, 1987Date of Patent: July 18, 1989Assignee: Mallinckrodt, Inc.Inventor: Alfons M. Verbruggen
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Patent number: 4806675Abstract: Pentaerythritol co-esters derived from pentaerythritol, (3-alkyl-4-hydroxyphenyl)-alkanoic acids and alkylthioalkanoic acids or lower alkyl esters of such acids are useful as stabilizers of organic material normally susceptible to oxidative and/or thermal deterioration. The co-esters are advantageously prepared by transesterification of such esters with pentaerythritol. Preferred co-esters are (I) pentaerythritol tris[3,5-di-tert-butyl-4-hydroxyphenyl)propionate]-mono[3-n-dodecylthiopro pionate] and (II) pentaerythritol bis[-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate]-bis[3-n-dodecylthiopro pionate]. The co-esters are especially useful in stabilizing applications for which physical mixtures of (i) (3-alkyl-4-hydroxyphenylalkanoic acid esters of polyols with (ii) polyalkanol esters of alkylthioalkanoic acids have heretofore been proposed.Type: GrantFiled: October 19, 1987Date of Patent: February 21, 1989Assignee: Mallinckrodt, Inc.Inventors: Neil Dunski, Ali A. Bazzi
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Patent number: 4794138Abstract: Pentaerythritol co-esters derived from pentaerythritol, (3-alkyl-4-hydroxyphenyl)-alkanoic acids and alkylthioalkanoic acids or lower alkyl esters of such acids are useful as stabilizers of organic material normally susceptible to oxidative and/or thermal deterioration. The co-esters are advantageously prepared by transesterification of such esters with pentaerythritol. Preferred co-esters are (I) pentaerythritol tris[3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate]-mono[3-n-do-decylthi opropionate] and (II) pentaerythritol bis[3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate]-bis[3-n-dodecylthiopr opionate]. The co-esters are especially useful in stabilizing applications for which physical mixtures of (i) (3-alkyl-4-hydroxyphenyl)alkanoic acid esters of polyols with (ii) polyalkanol esters of alkylthioalkanoic acids have heretofore been proposed.Type: GrantFiled: August 28, 1987Date of Patent: December 27, 1988Assignee: Mallinckrodt, Inc.Inventors: Neil Dunski, Ali A. Bazzi
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Patent number: 4781912Abstract: The invention relates to a cationic complex of technetium-99m with(a) at least one bidendate ligand X having the formulaR.sub.1 R.sub.2 ZQZR.sub.3 R.sub.4whereeach Z is phosphorus or arsenic,Q is a (CH.sub.2).sub.n linking group where n is 2 to 8 or a 1,2-phenylene linking group,each of R.sub.1, R.sub.2, R.sub.3 and R.sub.4 is hydrogen, C.sub.1 to C.sub.5 alkyl or phenyl; and(b) at least one monodentate isonitrile ligand Y.The invention also relates to a radiopharmaceutical composition comprising said complex, to a kit for preparing said composition, and to the use of said composition for a radiodiagnostic examination.Type: GrantFiled: December 15, 1986Date of Patent: November 1, 1988Assignee: Mallinckrodt, Inc.Inventors: Giuseppe D. Zanelli, Frank Brady, Niranjan M. Patel, Avijit Lahiri
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Patent number: 4775710Abstract: Disclosed are stabilized linear low-density polyethylene (LLDPE) compositions containing a stabilizing amount of a ring-substituted N-acyl-para-aminophenol. In a preferred embodiment, the latter compound is N-stearoyl-2,6-di-t-butyl-4-aminophenol.Type: GrantFiled: January 21, 1987Date of Patent: October 4, 1988Assignee: Mallinckrodt, Inc.Inventors: Neil Dunski, Henry J. Buehler
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Patent number: 4772740Abstract: The ethanolamine salt of N-nitrosophenylhydroxylamine ("NPHA") is effective as a polymerization inhibitor for ethylenically unsaturated monomers. The ethanolamine salt can be prepared by reacting ethanolamine with the ammonium salt of NPHA. Advantageously, the ethanolamine salt is soluble in high concentrations in water and a variety of polar organic solvents.Type: GrantFiled: March 5, 1985Date of Patent: September 20, 1988Assignee: Mallinckrodt, Inc.Inventor: John W. Varwig
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Patent number: 4772651Abstract: Polyol carboxyalkylthioalkanoesterphenol compounds useful in the stabilization of organic materials normally susceptible to oxidative degradation are prepared by reaction of an appropriate polythio, which is a selected tetra-(mercapto alkanoic acid) ester of pentaerythritol or a selected tri-(mercapto alkanoic acid) ester of a selected 1, 1, 1-trimethylolalkane, with an appropriate alkenyl compound, which is a selected 4-hydroxy-(mono- or di-alkyl)phenylalkylalkenoate. In a preferred embodiment, the compound is pentaerythritol tetrakis [3,5-di-tert-butyl-4-hydroxyphenyl-(3-propyl)oxycarbonylethylthiopropionat e].Type: GrantFiled: June 29, 1987Date of Patent: September 20, 1988Assignee: Mallinckrodt, Inc.Inventor: Neil Dunski
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Patent number: 4772741Abstract: Pentaerythritol co-esters derived from pentaerythritol, (3-alkyl-4-hydroxyphenyl)-alkanoic acids and alkylthioalkanoic acids or lower alkyl esters of such acids are useful as stabilizers of organic material normally susceptible to oxidative and/or thermal deterioration. The co-esters are advantageously prepared by transesterification of such esters with pentaerythritol. Preferred co-esters are (I) pentaerythritol tris[3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate]-mono[3-n-dodecylthio propionate]and (II) pentaerythritol bis [3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate]-bis[3-n-dodecylthiopropi onate]. The co-esters are especially useful in stabilizing applications for which physical mixtures of (i) (3-alkyl-4-hydroxyphenyl)alkanoic acid esters of polyols with (ii) polyalkanol esters of alkylthioalkanoic acids have heretofore been proposed.Type: GrantFiled: August 31, 1987Date of Patent: September 20, 1988Assignee: Millinckrodt, Inc.Inventors: Neil Dunski, Ali A. Bazzi
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Patent number: 4734290Abstract: Disclosed is a process for preparing a coated-particle salt substitute composition wherein a flow of a gaseous medium is passed upwardly through a bed including potassium chloride particles at a velocity more than sufficient to form and maintain a fluidized bed of the particles. A spray of an aqueous solution including maltodextrin is introduced into the fluidized bed below its upper surface to form a coating of the solution on the fluidized particles. The velocity is sufficient to also establish a particle-flow zone above and adjoining the upper surface of the fluidized bed wherein a substantial portion of the coated particles are propelled out of the fluidized bed on a flow path extending thereabove and returning thereto.Type: GrantFiled: December 12, 1985Date of Patent: March 29, 1988Assignee: Mallinckrodt, Inc.Inventor: David R. Meyer
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Patent number: 4734519Abstract: Pentaerythritol co-esters derived from pentaerythritol, (3-alkyl-4-hydroxyphenyl)-alkanoic acids and alkylthioalkanoic acids or lower alkyl esters of such acids are useful as stabilizers of organic material normally susceptible to oxidative and/or thermal deterioration. The co-esters are advantageously prepared by transesterification of such esters with pentaerythritol. Preferred co-esters are (I) pentaerythritol tris[3-(3,5-di-tert-butyl-4-hydroxylphenyl)propionate]-mono[3-n-dodecylthi opropionate] and (II) pentaerythritol bis[3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate]-bis[3-n-dodecylthiopr opionate]. The co-esters are especially useful in stabilizing applications for which physical mixtures of (i) (3-alkyl-4-hydroxyphenyl)alkanoic acid esters of polyols with (ii) polyalkanol esters of alkylthioalkanoic acids have heretofore been proposed.Type: GrantFiled: June 5, 1986Date of Patent: March 29, 1988Assignee: Mallinckrodt, Inc.Inventors: Neil Dunski, Ali A. Bazzi
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Patent number: 4730077Abstract: Alpha-arylalkanoic esters are prepared by reacting a trivalent iodine compound of the formula ##STR1## wherein Ar is an aromatic hydrocarbon and X and Y each represents a group which can be removed as an anion, with a carbonyl compound of the formula ##STR2## where Ar.sup.1 is an aromatic hydrocarbon, R is a hydrogen atom or an alkyl group, and R.sup.1 is a hydrogen atom or an alkyl group, in the presence of an orthocarboxylic ester having the general formula ZC(OR.sup.2).sub.3, wherein R.sup.2 is an alkyl group and Z is a hydrogen atom or an alkyl group; the reaction being carried out in a substantially anhydrous reaction mixture.Type: GrantFiled: July 12, 1986Date of Patent: March 8, 1988Assignee: Mallinckrodt, Inc.Inventor: Robert C. Chapman
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Patent number: 4727103Abstract: Isocyanurate esters of carboxyalkylthioalkanoesterphenols useful in the stabilization of organic materials normally susceptible to oxidative degradation are prepared by reacting an appropriate isocyanurate trithiol, which is a selected tris-mercapto alkanoic acid ester of tris-(2-hydroxyethyl) isocyanurate with an appropriate alkenyl compound, which is a selected 4-hydroxy-(mono- or di-alkyl)phenyl alkyl alkenoate. In a preferred embodiment, the ester is 1,3,5-tris [( 3,5-di-tert-butyl-4-hydroxyphenyl)-(3-propyl) oxycarbonylethylthiopropionyloxyethyl] isocyanurate.Type: GrantFiled: June 29, 1987Date of Patent: February 23, 1988Assignee: Mallinckrodt, Inc.Inventor: Neil Dunski
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Patent number: 4722956Abstract: Disclosed are stabilized A-B-A type block copolymer compositions containing at least two monoalkenyl arene polymer end blocks and at least one polydiene internal block and a stabilizing amount of a ring-substituted N-acyl-para-aminophenol. In two preferred embodiments, the latter compound is N-stearoyl-2,6-di-t-butyl-4-aminophenol, while the block copolymers are polystyrene-polybutadiene-polystyrene and polystyrene-polyisoprene-polystyrene, respectively.Type: GrantFiled: December 8, 1986Date of Patent: February 2, 1988Assignee: Mallinckrodt, Inc.Inventor: Neil Dunski
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Patent number: 4705678Abstract: The invention relates to a sterile aqueous solution for radioassaying a radioactive indium compound, which solution is entirely or substantially free from organic solvent, has a pH from 4 to 9, comprises a radioactive indium tropolonate or pyrithionate and has been subjected to a thermal sterilization.The invention also relates to the radioactive labelling of blood cells by treating a suspension of the blood cells with a sterile solution of a radioactive indium compound, in which either (a) a carbon-dioxide-generating substance is previously incorporated in the solution, or (b) a substance which under the labelling conditions generates carbon dioxide is added to the cell suspension, or carbon dioxide is passed through the cell suspension prior to or during the treatment.The invention furthermore relates to a kit for the radioactive labelling of blood cells.Type: GrantFiled: June 29, 1984Date of Patent: November 10, 1987Assignee: Mallinckrodt, Inc.Inventor: Wilhelmus T. Goedemans
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Patent number: 4680325Abstract: Isocyanurate esters of thioalkanoamidophenols useful in the stabilization of organic materials normally susceptible to oxidative degradation are prepared by reacting an appropriate isocyanurate trithiol, which is a selected tris-mercapto alkanoic acid ester of tris-(2-hydroxyethyl) isocyanurate with an appropriate alkenyl compound, which is a selected N-alkenyl[4-amino-(mono- or dialkyl)phenol] or, where the alkano moiety is a sole methylene group, by reaction of tris-(2-hydroxyethyl) isocyanurate with an appropriate [mercapto-N-(mono- or di-alkyl]-4-hydroxyphenylalkanamide alkenoic] acid. In a preferred embodiment, the ester is 1,3,5-tris{2-hydroxy ethyl-[3-mercapto-(3',5'-di-tert-butyl-4'-hydroxypropionanilide)]propionat e}isocyanurate.Type: GrantFiled: February 10, 1986Date of Patent: July 14, 1987Assignee: Mallinckrodt, Inc.Inventors: Neil Dunski, Ali A. Bazzi, Henry J. Buehler
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Patent number: 4663480Abstract: Disclosed is a process for inhibiting polymerization of polymerizable ethylenically unsaturated monomers such as hydrocarbons, acids and esters, wherein manganese nitrite, i.e. Mn(NO.sub.2).sub.2, is employed as an inhibitor. A composition including a polymerizable ethylenically unsaturated monomer and Mn(NO.sub.2).sub.2 is also disclosed. In two preferred embodiments, acrylic acid and styrene, respectively, are the monomers.Type: GrantFiled: June 5, 1985Date of Patent: May 5, 1987Assignee: Mallinckrodt, Inc.Inventors: Ervin B. Inskip, Douglas C. Caskey, William E. Dummitt
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Patent number: 4654299Abstract: A procedure for the immobilization of proteins on polystyrene surfaces which includes a pre-treatment of the polystyrene surface with a bis-diazonium compound of the general formula I where ##STR1## R1 stands for a hydrogen atom, a halogen atom, an alkyl group, an alkoxy group or a nitro group and whereR2 stands for a hydrogen atom, a halogen atom or an alkyl group and where X stands for an anion and the subsequent adsorption of the protein on the surface pretreated.Proteins immobilized by its procedure may be used in immunoassays.Type: GrantFiled: March 21, 1984Date of Patent: March 31, 1987Assignee: Mallinckrodt Diagnostica (Germany) GmbHInventor: Dierck Lentfer
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Patent number: 4642398Abstract: An improved process is disclosed for preparing fluoronitrobenzene compounds wherein chloronitrobenzene compounds are reacted with potassium fluoride in a solvent dispersion thereof prepared from a mixture including the solvent, the fluoride, methanol and an aromatic compound.Type: GrantFiled: January 6, 1986Date of Patent: February 10, 1987Assignee: Mallinckrodt, Inc.Inventor: Gary L. Cantrell
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Patent number: 4642399Abstract: A method is disclosed for producing fluoronitrobenzene compounds by reacting chloronitrobenzene compounds with a fluoride salt in the presence of a tetramethylammonium salt phase-transfer catalyst. This catalyst allows the use of elevated reaction temperatures with substantial freedom from catalyst inactivation, resulting in yields and reaction rates which are improved over those of previously known methods using higher molecular weight quaternary ammonium salt phase transfer catalysts having more total carbon atoms in their ammonium cations.Type: GrantFiled: November 29, 1984Date of Patent: February 10, 1987Assignee: Mallinckrodt, Inc.Inventor: Carl R. White