Abstract: In accordance with the present invention, a controlled release formulation is provided from which a drug, selected from the group consisting of angiotensin converting enzyme inhibitors and ascorbic acid, is released at a substantially controlled rate. The controlled release formulation of the invention is comprised of a reactive matrix of from about 5 to about 80 percent by weight of the drug in combination with from about 5 to about 70 percent by weight of poly[(1.fwdarw.4)-2-amino-2-deoxy-.beta.-D-glucose] (also referred to as chitosan herein). Further in accordance with the present invention there is provided a gel-like complex formed of the drug and the chitosan in environments ranging from neutral to acidic.

Abstract: A biological indicator is made of a vial which contains a "spore dot", a nutrient solution in a frangible ampoule, and means for positioning the spore dot and for breaking the ampoule to release the nutrient solution when the cap of the vial is fully pressed on. The nutrient solution typically contains a pH indicator to determine whether all active spores on the strip were killed by a sterilization process which takes place prior to breaking the ampoule.

Abstract: 7-Oxabicyclo(2.2.1)heptane-based N-hydroxy-N-alkyl (or aryl) ureas, carbamic acids and carbamothioic acids are disclosed having the general formula ##STR1## wherein R.sub.1 is hydrogen, lower alkyl, alkenyl, aryl or aralkyl; R.sub.2 is hydrogen, lower alkyl, aralkyl, alkanoyl or aroyl; R.sub.3 is lower alkyl, alkenyl or alkynyl; A is --CH.sub.2 --CH.dbd.CH-- or a single bond; X is oxygen, sulfur or NH; n is an integer from 1 to 8; and all stereoisomers thereof.These new compounds have been found to simultaneously inhibit the enzymes arachidonic acid cyclooxygenase and arachidonic acid 5-lipoxygenase and are therefore useful as antiinflammatory, antiasthma and antipsoriatic agents.

Abstract: A compound of the formula ##STR1## wherein R.sub.1 is hydrogen, hydroxy, alkoxy or aryloxy; R.sub.2 is hydrogen, hydroxy, alkoxy or aryloxy; or wherein R.sub.1 and R.sub.2 taken together is an aromatic ring; R.sub.3 is hydrogen or lower alkyl; R.sub.4 is lower alkyl, substituted alkyl, alkenyl or alkynyl; X is amino, alkylamino, alkanoylamino, oxygen or a single bond; A is CH.sub.2 --CH.dbd.CH or a single bond; and n is an integer from 0 to 9, with the proviso that when A is a single bond, n is an integer from 1 to 9 including all stereoisomers thereof.These new compounds have been found to simultaneously inhibit the arachidonic acid enzymes 5-lipoxygenase and cyclooxygenase and as such are useful, for example, as antiinflammatory agents.

Abstract: A catheter support comprising an anchoring pad and a flexible strap, a portion of which is attached thereto, is disclosed. One side of the anchoring pad carries an adhesive compatible for use with human skin. One side of the strap carries a fastener material. With the pad in place, a catheter is laid against the pad, and the free end of the strap is folded across the catheter. The fastener material of the free end is pressed against the fastener material attached to the pad to hold the catheter in place. Alternatively, the side of the pad opposite the side with the adhesive carries fastener material, and the flexible strap is separate therefrom. A channel is present through the fastener material on either the pad, flexible strap or both to receive the catheter.

Abstract: A coupling for joining a pad or dressing to an ostomy bag includes coupling elements each of closed loop form, usually circular to define a stoma aperture therein, the body side element being constructed so that it can be fixed to the pad or dressing and the bag side element being constructed so that it can be fixed to one wall of an ostomy bag. The body side element includes an inner wall which continuously encircles the aperture and a series of projecting members uniformly radially spaced from the inner wall and located in an array which surrounds the inner wall. The bag side element includes a rib member encircling the aperture for making sealing engagement, when the coupling elements are joined, with the outer surface of the inner wall. The coupling also has an annual ring which is constructed to be snap-fitted to the body side coupling element to extend radially outwardly therefrom.

Abstract: Disclosed herein is a pharmaceutically active gelled composition of dimethyl sulfoxide for utilization in the treatment of musculoskeletal disorders.

Abstract: Cephalosporins of the formula ##STR1## wherein R is hydrogen, sodium, potassium, or certain ester groups; R.sub.1 is in the .alpha.-configuration and is hydrogen or methoxy; R.sub.2 is hydrogen, lower alkyl, cycloalkyl, cycloalkenyl, cycloalkadienyl, substituted or unsubstituted phenyl, benzyl, phenethyl, thienyl, furyl, or pyridyl, or 2-amino-4-thiazolyl; X is --CH.sub.2 --, --CH.sub.2 --CH.sub.2 --, ##STR2## R.sub.3 is hydrogen, ##STR3## --O--lower alkyl, or certain substituted or unsubstituted heterothio groups; are disclosed. These compounds possess useful antibacterial activity.