Abstract: The present invention relates to the use of a compound of formula (I), or a pharmaceutically acceptable salt thereof, in therapy. Prefereably, the compound may be used for treating a patient suffering from leukaemia, cancer or other proliferative disorder. A further embodiment relates to the use of a compound of formula (I) in an assay for detecting the phosphorylation and acetylation state of cellular substrates. The present invention also relates to novel compounds of formula (Ia).

Abstract: A method and apparatus for enabling interactive programming and/or development environments with the ability to dynamically host ActiveX controls and Java components simultaneously in the same figure window is provided. This type of hosting ActiveX controls is different from the industry standard in that the ActiveX control can be chosen dynamically at runtime. A Java container is disposed in a Java-based operating system window. A plurality of Java canvases are configured in the figure window, such that each Java canvas is supported by the Java container. A plurality of components are positioned on the plurality of Java canvases. Each of the plurality of components can be dynamically added and removed from the plurality of Java canvases without re-creation of the operating system window. Furthermore, at least one of the components does not contain a Java class or a Java interface.

Abstract: The invention provides methods and compositions for treating and preventing a skin rash secondary to anti-epidermal growth factor receptor (EGFR) therapy, where the method comprises applying a vitamin K analog or a phosphatase inhibitor to the skin.

Abstract: Compositions and methods comprising “lymphotoxin-? receptor blocking agents” which block lymphotoxin-? receptor signaling and are useful for altering immunological diseases, and particularly antibody mediated immune responses.

Abstract: A fuel cell system includes a raw fuel supply channel. A raw fuel supply apparatus, a desulfurizer, and a flow rate meter are provided in the raw fuel supply channel such that the desulfurizer is provided downstream of the raw fuel supply apparatus, and the flow rate meter is provided downstream of the desulfurizer. The raw fuel supply channel includes a first channel area provided upstream of the raw fuel supply apparatus, a second channel area provided downstream of the raw fuel supply apparatus, and upstream of the flow rate meter, a bypass channel having both ends connected to the first channel area and the second channel area, and an open/close valve for opening and closing the bypass channel based on the pressure in the first channel area and the pressure in the second channel area.

Abstract: A separator comprises a first and second metal plates laid over each other. A cooling medium flow passage is integrally provided between the first and second metal plates. The cooling medium flow passage has inlet buffer portions communicating with a cooling medium inlet communication hole, outlet buffer portions communicating with a cooling medium outlet communication hole, and linear flow passage grooves linearly extending in the direction of arrow B and that of arrow C.

Abstract: Isolated nucleic acid molecules encoding T-bet, and isolated T-bet proteins, are provided. The invention further provides antisense nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals carrying a T-bet transgene. The invention further provides T-bet fusion proteins and anti-T-bet antibodies. Methods of using the T-bet compositions of the invention are also disclosed, including methods for detecting T-bet activity in a biological sample, methods of modulating T-bet activity in a cell, and methods for identifying agents that modulate the activity of T-bet.

Abstract: The present invention provides a particulate delivery system comprising an extracted yeast cell wall comprising beta-glucan, a payload molecule and a payload trapping molecule. The invention further provides methods of making and methods of using the particulate delivery system.

Abstract: The present invention provides a method and system for the dynamic distribution of an array in a parallel computing environment. The present invention obtains a criterion for distributing an array and performs flexible portioning based on the obtained criterion. In some embodiment analysis may be performed based on the criterion. The flexible portioning is then performed based on the analysis.

Abstract: A method of making a set of labelled compounds by the use of a preferably particulate support, comprises dividing the support into lots, performing a different chemical reaction on each lot of the support, e.g. to couple a chemical moiety to that lot of the support, tagging a fraction of each lot of the support with a different label, and combining the said lots of the support. The steps are repeated several times, preferably to build up oligomer molecules carrying labels which identify the nature and position of a monomer unit of the oligomer, and which are releasable from the support. Preferred labels, which are releasable from the compounds by cleavage to provide charged groups for analysis by mass spectrometry, are groups of the trityl (trimethylphenyl) family. Also claimed are libraries of these labels and their use in assays and nucleic acid analysis methods.

Abstract: A method and system for providing a block for use in a block diagram in a graphical modeling environment which is capable of outputting information regarding the dynamic state of the block.

Abstract: A method of making a radially expandable fluid delivery device includes providing a tube of biocompatible fluoropolymer material with a predetermined porosity based on an extrusion and expansion forming process, applying a radial expansion force to the tube expanding the tube to a predetermined diameter dimension, and removing the radial expansion force. The tube is radially inelastic while sufficiently pliable to be collapsible and inflatable from a collapsed configuration to an expanded configuration upon introduction of an inflation force, such that the expanded configuration occurs upon inflation to the predetermined diameter dimension. The fluid delivery device is constructed of a microporous, biocompatible fluoropolymer material having a microstructure that can provide a controlled, uniform, low-velocity fluid distribution through the walls of the fluid delivery device to effectively deliver fluid to the treatment site without damaging tissue proximate the walls of the device.

Abstract: This invention allows users to build, manipulate, and finally deploy various model configurations with little performance overhead, better syntactic clarity and configuration flexibility.

Abstract: Methods and systems for controlling versions of models in modeling environments are disclosed. The versions of models and component interfaces are stored in a repository and checked in and out of the repository. The version designation of a model is changed when the model is checked in the repository. A selected version of the model is checked out of the repository and loaded directly in a memory so that users may load the selected version of the model without error. The loaded model is displayed with information on the version of the model. The version information may include the version number and author of the version. The version information may also include information on whether the model is locked with a version or in a read only mode.

Abstract: A fuel cell stack includes a stack body formed by stacking a plurality of unit cells in a horizontal direction. The stack body is held in a casing including end plates. Further, the casing includes a plurality of side plates provided on sides of the stack body. The end plates and the side plates are coupled by coupling pins. Each of the side plates has a plurality of separate second coupling portions, and the coupling pins are inserted into the coupling portions.

Abstract: A scroll compressor, wherein a guide passage facing the supply passage of a fixed side substrate part is formed at the outer peripheral portion of a fixed scroll engaged with a movable scroll along the axial direction of the fixed scroll. A lubricating oil is stored in an oil storage tank surrounded by a set of weir walls formed along the guide passage and the movable side substrate part of the movable scroll facing a fixed side spiral wall. The movable side substrate part is radially displaced by the turning action of the movable scroll to supply the lubricating oil stored in the oil storage tank to the movable scroll side.

Abstract: Provided is an operational status testing apparatus and method for an Ethernet-based APS process. A test command signal which contains a command to perform an operational test for the APS process of a first node and a second test response signal that indicates that the operation of the APS process of a second node is performed normally, from among far end request signals that are received from the second node connected to own first node via an Ethernet network, are filtered.

Abstract: A method for forecasting batch end conditions through their depiction as a multi-dimensional regions of uncertainty is disclosed. A visualization of the current condition of a continuous process and visualization of the simulated effect of user control moves are generated for a user. Volume visualization tools for viewing and querying intersecting solids in 3-dimensional space are utilized to perform the process visualization. Interactive tools for slicing multi-dimensional (>3) regions and drawing superimposed projections in 3-D space are provided. Additionally, graphical manipulation of the views of process conditions is accomplished by changing the hypothetical future values of contributing variables online in order to provide users the ability to simulate the effect of proposed control actions.