Abstract: This invention relates to new compositions comprising at least one of a single or double stranded oligonucleotide, where said oligonucleotide has been conjugated to a lipophile and to which the conjugated oligonucleotide has been preassembled with lipoproteins. These compositions are effectively in delivering oligonucleotides to mammalian tissue where they effect gene silencing.

Abstract: According to one aspect, embodiments of the invention provide a method of monitoring an electrical connection, the method comprising monitoring a temperature of the electrical connection, monitoring a level of current passing through the electrical connection, and determining, in response to monitoring temperature and current, whether the temperature of the electrical connection exceeds a temperature threshold associated with the level of current passing through the electrical connection.

Abstract: According to one embodiment of the present disclosure, a system for generating a reconstructed image generally includes a carrier substrate, a number of image sensors, and an image processing circuit. The image sensors are mounted on a surface of the carrier substrate. The image processing circuit is coupled to each of the image sensors and operable to receive a raw image from each of a plurality of image sensors and combine the raw image of each of the image sensors into the reconstructed image.

Abstract: A circuit board assembly includes a circuit board having an outer surface, the outer surface being configured with a plurality of discrete electrical components that are each manufactured independently of one another. The circuit board assembly further includes a domed lid enclosure disposed over one of the plurality of discrete electrical components and an additional dielectric coating overlying the outer surface and the domed lid enclosure.

Abstract: The systems and methods described herein relate to an airborne shooter detection system having a plurality of sensors coupled to the body of an aircraft such as a helicopter. The sensors are arranged to receive shockwave-only signals. The received signals are analyzed to determine an unambiguous shooter location. The analysis may include measuring the arrival times of the shockwaves of projectiles at each of the sensors, determining the differences in the arrival times among sensors, computing a set of ambiguous solutions corresponding to a shooter, and clustering this set of solutions to determine the unambiguous shooter location. The systems and methods described herein may also be used to determine if multiple shooters are present, and subsequently determine the shooter locations for each of the multiple shooters.

Abstract: Compounds and compositions for treating injuries caused by exposure to chemical warfare agents are described herein.

Abstract: A latched comparator circuit comprises an input amplification unit, a buffer unit, and a control unit. The input amplification unit comprises a first and a second input terminal for receiving a first and a second input voltage, respectively, of the latched comparator circuit. The input amplification unit further comprises a first and a second output terminal for outputting a first and a second output voltage, respectively, of the input amplification unit. In addition, the input amplification unit comprises a reset terminal arranged to receive a reset signal for resetting the input amplification unit. The buffer unit is operatively connected to the first and the second output terminal of the input amplification unit. Furthermore, the buffer unit comprises a first and a second output terminal for outputting a first and a second output voltage, respectively, of the buffer unit. The control unit is operatively connected to the input amplification unit and the buffer unit.

Abstract: A system and method is provided for translating one or more logical expressions E is TRUE, or statements of the form IF E1 is TRUE THEN E2 is TRUE, to a set of linear constraints. Examples in accordance with the present invention contribute to systems and methods for solving optimization problems that include constraints in the form of arbitrarily complex logical relationships between binary variables. Examples are also applicable to solving general optimization problems that have arbitrarily complex relationships between sets of linear constraints. The systems and methods combine simplification and ordering of logical expressions, factorization, direct translations of expressions, substitution of auxiliary variables, and substitution of auxiliary variables for phrases that would otherwise lead to an unacceptable number of linear constraints.

Abstract: Ceramic dielectric materials that can be utilized as electronic components, such as dielectric resonators are disclosed. The material can have a formula Ba12M?(28+a/3)Ti(54?a-b)M?aGebO162, wherein M? is at least one rare earth element selected from the group consisting of lanthanum, neodymium, samarium, gadolinium, and yttrium, M? is at least one element selected from the group consisting of aluminum, gallium, chromium, indium, scandium, and ytterbium, 0?a?6, and 0?b?3. The ceramic dielectric material can also have a formula Ba12M?(28+2x/3)Ti(54?x?y)M??xGeyO162, wherein M? is at least one rare earth element selected from the group consisting of lanthanum, neodymium, samarium, gadolinium, and yttrium, M?? is at least one metal selected from the group consisting of magnesium, zinc, nickel, and cobalt, 0?x?3, and 0?y?3. One or more aspects of the present invention pertain to methods of fabricating a dielectric component. Methods of synthesizing the disclosed ceramic dielectric materials are also disclosed.

Abstract: A device including a heat sensitive substrate and an electrical conductor disposed thereon is provided. In certain examples, the heat sensitive substrate may be configured to degrade at or above a sintering temperature. In other examples, the electrical conductor may be processed, prior to disposal on the heat sensitive substrate, at the sintering temperature on a second substrate that can withstand the sintering temperature. Methods and kits are also disclosed.

Abstract: The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.

Abstract: Systems and methods are provided for determining data center cooling and power requirements and for monitoring performance of cooling and power systems in data centers. At least one aspect provides a system and method that enables a data center operator to determine available power and cooling at specific areas and enclosures in a data center to assist in locating new equipment in the data center.

Abstract: A self-sealing valve comprises a valve housing having a fluid conduit, a valve seat, a diaphragm and a support member. The valve housing is configured to pass fluid through the fluid conduit. The diaphragm provides a self-seal of the fluid conduit. The support member is configured to retain a portion of a diaphragm. The support member and diaphragm are configured to position the flexible diaphragm against the valve seat to seal the fluid conduit in a closed position of the self-sealing valve, and to facilitate movement of the diaphragm under a bias in a first direction away from the valve seat to an open position.

Abstract: A fluid delivery system that includes flow substrates and manifolds that minimize the number of fluid conduit ports and seals needed to build standardized fluid delivery sticks. Each flow substrate has a component attachment surface with one or more component conduit ports and an associated plurality of fastener apertures. Some flow substrates incorporate a transverse manifold connection conduit port on a surface opposite the component attachment surface. Fastener apertures associated with the transverse manifold connection conduit port are accessible adjacent to installed fluid handling components. Transverse connection between fluid delivery sticks use a welded assembly of fluid conduits to provide a transverse connecting lower layer which is sealingly retained by fasteners inserted from above through apertures associated with the transverse manifold connection conduit port.

Abstract: Provided is an apparatus and method for providing a fail-safe in a head lamp apparatus.

Abstract: Certain examples disclosed herein are directed to devices that include a substrate and conductor disposed on the substrate. In some examples, each of the conductor and the substrate may include materials that are mutually insoluble in each other. In other examples, the conductor may further comprise a substantially pure metal. In certain examples, the disposed conductor may be configured to pass adhesion tape test ASTM D3359-02. Methods of forming the conductors are also provided.

Abstract: The present invention provides compositions and methods for increasing absorption of antibacterial agents, particularly third generation cephalosporin antibacterial agents, in oral dosage solid and/or suspension forms. Specifically, the composition is comprised of a biopolymer that is preferably swellable and/or mucoadhesive, a antimicrobial agent, and a cationic binding agent contained within the biopolymer such that the binding agent is ionically bound or complexed to at least one member selected from the group consisting of the biopolymer and the antimicrobial agent.

Abstract: The present invention is directed to systems and methods of synthesizing trichlorosilane. The disclosed systems and methods can involve increasing the concentration of the solids in the slurry to recover or separate the volatilized metal salts and reduce the obstructions created by the solidification of the metal salts in downstream operations of the during trichlorosilane synthesis. Rather than heating to raise the temperature to vaporize chlorosilane compounds, and subsequently condensing the volatilized chlorosilane compounds, the present invention can involve increasing the solids concentration in the slurry stream by utilizing a non-condensable gas, such as hydrogen, to volatilize the chlorosilane components, which can consequently promote evaporative conditions that can reduce the slurry temperature. The lower slurry temperature results in a lower volatility of the metal salts, which reduces the likelihood of carryover to downstream unit operations.

Abstract: An optical detector includes a detector surface operable to receive light, a depleted field region coupled to the underside of the detector surface, a charge collection node underlying the depleted field region, an active pixel area that includes the portion of the depleted field region above the charge collection node and below the detector surface, and two or more guard regions coupled to the underside of the detector surface and outside of the active pixel area. The depleted field region includes an intrinsic or a near-intrinsic material. The charge collection node has a first width, and the guard regions are separated by a second width that is greater than the first width of the charge collection node. The guard regions are operable to prevent crosstalk to an adjacent optical detector.

Abstract: Systems and methods of processing a video signal are provided. A potential block boundary can be detected between a first block and a second block of a frame of the video signal, wherein the frame, the first block, and the second block each include a plurality of pixels. An offset parameter can be determined for at least one pixel of at least one of the first block and the second block. Based on the offset parameter, a boundary verification value of at least one of the first block and the second block can also be determined. Based on the boundary verification value, it can further be determined if the potential block boundary includes a block boundary.