Abstract: The present disclosure provides among other things immunoassays exhibiting reduced cross-reactivity with analyte metabolites. Additionally, the present disclosure provides diagnostic immunoassays to determine the concentration or level in a test sample of a hydrophobic drug that metabolizes in vivo or in vitro to form cross-reacting metabolites wherein cross-reactivity with such metabolites of the drug analyte is reduced. In particular, the disclosure provides such immunoassays where the hydrophobic drug is an immunosuppressant drug such as cyclosporine A.
Type:
Grant
Filed:
May 23, 2008
Date of Patent:
October 16, 2012
Assignee:
Abbott Laboratories
Inventors:
Elaine M. Brate, David M. Finley, Shelley R. Holets-McCormack, David P. Pacenti, Ryan E. Piktel, Michelle L. Shields, Thomas G. Spring, Phillip P. Wang