Abstract: A sterile medical liquid container system that includes an inner cap and an outer cap nested together and having interconnecting splines. The inner cap has internal right-handed threads and is screwed onto a threaded bottle neck to hermetically seal this neck. The outer cap has external left-handed threads and is fused at a frangible joint to the thermoplastic bottle. A jacking ring with internal left-handed threads screws onto the outer cap and a continuous clockwise motion of the jacking ring acts to (1) fracture the outer cap, and (2) unscrew the combined intersplined inner and outer caps from the container neck.

Abstract: A parenteral liquid bottle with a sealed leak testing chamber in its closure. This leak testing chamber has an opening sealed off by a protective thermoplastic-metal film with a permanently stretched section extending across the opening. This permanently stretched section of the film maintains either a "concave" or a "convex" shape without a pressure differential across the film. A vacuum source temporarily applied to an external surface of the film causes the film to "toggle" from its concave to its convex position indicating the chamber is properly sealed. Failure to so toggle indicates a leak in the chamber.