Patents Represented by Attorney Larson & Anderson, LLC
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Patent number: 8333767Abstract: A cerclage device includes a base member, a cerclage member, and a drive member. The base member has a length sufficient to allow for manual holding by a user, an interior space extending from a distal end toward a proximal end, and a slot extending from the distal end toward the proximal end. The cerclage member has a long side with a proximal end and a distal end and a curvature in one direction about its long side at least at the distal end. The cerclage member allows for attaching a suture and fits within and is straightened by the base member within the interior space when in a retracted position. When the drive member is attached to the cerclage member movement of the engagement portion in the slot pushes and pulls the cerclage member to/from the straightened position from/to the extended curved position.Type: GrantFiled: April 28, 2010Date of Patent: December 18, 2012Inventor: Erik Dorf
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Patent number: 8329025Abstract: The presence of oxygen or red blood cells in a sample applied to an electrochemical test strip that makes use of a reduced mediator is corrected for by an additive correction factor that is determined as a function of the temperature of the sample and a measurement that reflects the oxygen carrying capacity of the sample. The measured oxygen carrying capacity can also be used to determine hematocrit and to distinguish between blood samples and control solutions applied to a test strip.Type: GrantFiled: May 12, 2011Date of Patent: December 11, 2012Assignee: AgaMatrix, Inc.Inventors: Ian Harding, Richard Williams, Sridhar Iyengar
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Patent number: 8323893Abstract: Certain genes controlled by endogenous miRNA are actually upregulated upon the transfection of exogenous mi/siRNA. Based on this, methods of determining whether administration of mi/siRNA will have a deleterious effect by upregulating certain genes are provided. Comparison of sequences of exogenous mi/siRNA allows selection of exogenous miRNA to be administered to cell to enhance or limit this affect, and therefore to control unwanted disregulation, or to upregulate an endogenous miRNA-regulated gene of interest.Type: GrantFiled: October 19, 2010Date of Patent: December 4, 2012Assignee: Sloan-Kettering Institute for Cancer ResearchInventors: Christina S. Leslie, Debora S. Marks
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Patent number: 8324280Abstract: Prostate cancer comes in various forms and has proven difficult to treat. Provided herein are various methods and compositions for treating all forms of prostate cancers with dopa decarboxylase (DDC) inhibitors. These dopa decarboxylase inhibitors include carbidopa (?-Methyl-dopahydrazine), MFMD (?-monofluoromethyldopa), NSD-1015 (3-hydroxybenzylhydrazine), Methyldopa (L-?-Methyl-3,4-dihydroxyphenylalanine) or benserazide, and the inhibitors may be used in combination. DDC inhibitors may also be used to inhibit the progression of prostate cancer to androgen-independence and neuroendocrine prostate cancer.Type: GrantFiled: August 7, 2009Date of Patent: December 4, 2012Assignee: The University of British ColumbiaInventors: Latif Wafa, Paul Rennie
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Patent number: 8325041Abstract: A system for identifying, monitoring, and tracking a firearm includes: a low frequency radio tag affixed to the firearm, the radio tag configured to receive and send data signals, the radio tag including: a tag antenna operable at a low radio frequency not exceeding 450 kilohertz, a transceiver operatively connected to the tag antenna, the transceiver configured to transmit and receive data signals at the low radio frequency; a data storage device configured to store data including identification data for identifying the firearm, and a data processor configured to process data received from the transceiver and the data storage device and to transmit data to cause the transceiver to emit an identification signal based upon the identification data stored in the data storage device.Type: GrantFiled: April 24, 2008Date of Patent: December 4, 2012Assignee: Visible Assets, Inc.Inventors: Jason August, John Stevens, Paul Waterhouse
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Patent number: 8309794Abstract: The present invention relates to constructs including one or more nucleic acids encoding two or more oleosin repeat units, and methods of use thereof. The present invention also relates to recombinant polypeptides including two or more oleosin repeat units, and methods of use thereof.Type: GrantFiled: October 16, 2006Date of Patent: November 13, 2012Assignees: Agriculture Victoria Services Pty Ltd, AgResearch LimitedInventors: Richard William Scott, Vickery Laurence Arcus, Nicholas John Roberts
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Patent number: 8303787Abstract: Systems and methods are provided herein for improving the selectivity and productivity of sensors via digital signal processing techniques. According to one illustrative embodiment, in an electrochemical method for monitoring of a select analyte in a mixed sample with an interfering analyte, an improvement is provided that includes applying a large amplitude potential stimulus waveform to the sample to generate a nonlinear current signal; and resolving a signal contribution from the select analyte in the generated signal by a vector projection method with an analyte vector comprising a plurality of real and imaginary parts of one or more Fourier coefficients at one or more frequencies of a reference current signal for the select analyte.Type: GrantFiled: October 21, 2010Date of Patent: November 6, 2012Assignee: Agamatrix, Inc.Inventors: Sridhar G. Iyengar, Daniel Haas, Craig Bolon, Ian Harding
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Patent number: 8299078Abstract: T cell lymphoma is treated by administering to a patient suffering from T cell lymphoma a therapeutically effective amount of 10-propargyl-10-deazaaminopterin. Remission is observed in human patients, even with drug resistant T cell lymphoma at weekly dosages levels as low as 30 mg/m2. In general, the 10-propargyl-10-deazaaminopterin is administered in an amount of from 30 to 275 mg/m2 per dose.Type: GrantFiled: October 21, 2009Date of Patent: October 30, 2012Assignee: Sloan-Kettering Institute for Cancer ResearchInventors: Owen A. O'Connor, Francis M. Sirotnak
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Patent number: 8293094Abstract: A method for monitoring a select analyte in a sample in an electrochemical system. The method includes applying to the electrochemical system a time-varying potential superimposed on a DC potential to generate a signal; and discerning from the signal a contribution from the select analyte by resolving an estimation equation based on a Faradaic signal component and a nonfaradaic signal component.Type: GrantFiled: October 9, 2009Date of Patent: October 23, 2012Assignee: AgaMatrix, Inc.Inventors: Sridhar G. Iyengar, Ian S. Harding
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Patent number: 8268145Abstract: Electrochemical test cells are made with precision and accuracy by adhering an electrically resistive sheet having a bound opening to a first electrically conductive sheet. A notching opening is then punched through the electrically resistive sheet and the first electrically conductive sheet. The notching opening intersects the first bound opening in the electrically resistive sheet, and transforms the first bound opening into a notch in the electrically resistive sheet. A second electrically conductive sheet is punched to have a notching opening corresponding to that of first electrically conductive sheet, and this is adhered to the other side of the electrically resistive sheet such that the notching openings are aligned. This structure is cleaved from surrounding material to form an electrochemical cell that has a sample space for receiving a sample defined by the first and second conductive sheets and the notch in the electrically resistive sheet.Type: GrantFiled: May 20, 2005Date of Patent: September 18, 2012Assignee: AgaMatrix, Inc.Inventors: Ian Harding, Sridhar G. Iyengar, Marina T. Larson, Carl Oppedahl
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Patent number: 8263354Abstract: Sensitivity of a patient's cancer to treatment with 10-propargyl-10-deazaaminopterin is assessed and patients are selected for treatment of cancer with 10-propargyl-10-deazaaminopterin, by determining the amount of a selected polypeptide expressed by the cancer and comparing the amount with the amount of the selected polypeptide expressed by a reference cancer. The polypeptide includes a member of a folate pathway polypeptide within a cell and may include at least one of reduced folate carrier-1 enzyme (RFC-1), dihydrofolate reductase (DHFR), folylpoly-gamma-glutamate synthetase (FPGS), thymidylate synthase (TS), ?-glutamyl hydrolase (GGH), and glycinamide ribonucleotide formyltransferase (GARFT).Type: GrantFiled: June 14, 2010Date of Patent: September 11, 2012Assignee: Sloan-Kettering Institute for Cancer ResearchInventors: Owen A. O'Connor, Francis M. Sirotnak
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Patent number: 8257651Abstract: In one embodiment the present invention provides a blood analyte meter that is user-friendly and easy to use. In accordance with an embodiment of the present invention an analyte measurement device, for use with a test strip for determining the amount of an analyte in a sample, displays a hierarchy of information or options to a user. The hierarchy of information or options may include, among other information or options, subroutines that are performable by the processor of the device, stored data related to past tests performed by the user, and alarm features of the device. A user scrolls through and selects individual options or pieces of information by rotating and translating a rotatable user interface around and along an axis of rotation.Type: GrantFiled: March 16, 2006Date of Patent: September 4, 2012Assignee: AgaMatrix, Inc.Inventors: Joseph Flaherty, Timothy Golnik
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Patent number: 8252765Abstract: Agents that reduce the amount of IGFBP-2 and/or IGFBP-5 and that are known to be useful in the treatment of cancer result in increased expression of the protein clusterin. Since clusterin can provide protection against apoptosis, this secondary effect detracts from the efficacy of the therapeutic agent. In overcoming this, the present invention provides a combination of therapeutic agents that is useful in the treatment of cancer. The combination includes an agent that reduces the amount of IGFBP-2 and/or IGFBP-5 and that stimulates expression of clusterin as a secondary effect, and an oligonucleotide that is effective to reduce the amount of clusterin in cancer cells. In some embodiments of the invention, the agent that reduces IGFBP-2 and/or IGFBP-5 is a bispecific antisense species. The oligonucleotide may be an antisense oligonucleotide or an RNAi oligonucleotide.Type: GrantFiled: April 15, 2011Date of Patent: August 28, 2012Assignee: The University of British ColumbiaInventor: Martin E. Gleave
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Patent number: 8252918Abstract: RNAi sequences that are useful as therapeutics in the treatment of cancers of various types, including prostate cancer, sarcomas such as osteosarcoma, renal cell carcinoma, breast cancer, bladder cancer, lung cancer, colon cancer, ovarian cancer, anaplastic large cell lymphoma and melanoma; and Alzheimer's disease. These sequences target clusterin, IGFBP-5, IGFBP-2, both IGFBP-2 and -5 simultaneously, Mitf, and B-raf. The invention further provides for the use of these RNAi sequences in the treatment of cancers of various types, including prostate cancer, sarcomas such as osteosarcoma, renal cell carcinoma, breast cancer, bladder cancer, lung cancer, colon cancer, ovarian cancer, anaplastic large cell lymphoma and melanoma; and Alzheimer's disease, and a method of treating such conditions through the administration of the RNA molecules with RNAi activity to an individual, including a human individual in need of such treatment.Type: GrantFiled: August 21, 2003Date of Patent: August 28, 2012Assignee: The University of British ColumbiaInventors: Martin E. Gleave, Burkhard Jansen, Ioannis P. Trougakos, Efstathios Gonos, Maxim Signaevsky, Eliana Beraldi
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Patent number: 8247619Abstract: Bio-derived bisphenol A is made by combining bio-derived phenol and/or bio-derived acetone in the presence of a catalyst, The phenol or the acetone or both contain at least 0.5%, for example at least 1 weight % of bio-derived impurities. In the case of bio-derived phenol, these impurities may include one or more of 2-methylbenzofuran, 2-methoxyphenol, 2-methylphenol, 4-methylphenol (para-cresol) or 2-methoxy-4-methylphenol. In the case of acetone, the impurity may be ethanol, mesityl acetone and/or diacetone alcohol. This bio-derived BPA can be used in the production of polycarbonates with less fossil fuel-based carbon content.Type: GrantFiled: December 11, 2009Date of Patent: August 21, 2012Assignee: Sabic Innovative Plastics IP B.V.Inventor: James A. Mahood
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Patent number: 8232494Abstract: A keyboard, wherein an opposing force generated between two magnet faces of the same polarity is used to return each key button to its original position after being pressed. As a result, the keyboard can be made capable of withstanding harsh environments while offering a satisfactory tactile response for the user.Type: GrantFiled: December 12, 2006Date of Patent: July 31, 2012Inventor: Dale McPhee Purcocks
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Patent number: 8223019Abstract: A method for identifying, tracking, and monitoring a firearm includes steps of: attaching a low frequency radio tag to the firearm; storing, in the data storage device of the radio tag, identification data relating to the firearm; and reading the identification data from the transceiver by interrogating the radio tag. The radio tag includes a shot sensor, a shot count register for tracking the number of shots fired and cadence registers for tracking the intervals between shots.Type: GrantFiled: July 27, 2009Date of Patent: July 17, 2012Assignee: Visible Assets, Inc.Inventors: M. Jason August, John K. Stevens, Paul Waterhouse
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Patent number: 8207336Abstract: Bis-(4,4?dimethyl-2,2?bipyridyl) picolinate osmium complexes are useful as mediators in the electrochemical test strips, such as those used in the detection of glucose.Type: GrantFiled: January 13, 2011Date of Patent: June 26, 2012Assignee: AgaMatrix, Inc.Inventor: Ian Harding
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Patent number: 8196235Abstract: An emergency eye wash valve which can be connected to an IV fluid bag or other reservoir of fluid easily controllable flow of liquid to two eye wash arms which are independently positionable to dispense the liquid into the eyes of a patient in need of emergency eye wash. In addition, the valve has a base member which can be affixed via a biocompatible adhesive to the patient (for example on the forehead or bridge of the nose) to hold the valve in position so that it does not have to held in place by a person during the eye washing process.Type: GrantFiled: March 27, 2009Date of Patent: June 12, 2012Inventor: Gary Dudley
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Patent number: 8192610Abstract: Measurement of the series track resistance of a working and counter electrode pair in an electrochemical test strip provide error detection for multiple variations in the quality of the test strip, as well as the operation of strip in the test meter. In particular, a single measurement of series resistance can be used to detect and generate an error message when an incorrect reading is likely to result due to (1) damaged electrode tracks, (2) fouled electrode surfaces, (3) dirty strip contacts, or (4) short circuit between the electrodes.Type: GrantFiled: December 7, 2010Date of Patent: June 5, 2012Assignee: AgaMatrix, Inc.Inventors: Steven Diamond, Ian Harding, Richard Williams