Patents Represented by Attorney Laura A. Handley

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  • Ribozymes with product ejection by strand displacement
    Patent number: 5631148
    Abstract: Ribozymes designed to provide improved rates of catalytic turnover are described. The compounds of this invention comprise a catalytic region, at least one substrate binding region, and at least one displaceable antisense arm, whereby the rate of release of the endonuclease cleavage fragments is enhanced. A method to make such ribozymes is also described.
    Type: Grant
    Filed: April 22, 1994
    Date of Patent: May 20, 1997
    Assignee: Chiron Corporation
    Inventor: Michael S. Urdea