Patents Represented by Attorney Laura B. Arciniegas
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Patent number: 7901673Abstract: A process for damaging and maintaining damage to the nucleic acids of pathogens such as white blood cells, bacteria and viruses which may be contained in blood or blood components. This process comprises adding to the blood or blood component containing pathogens an effective amount of riboflavin, and exposing the fluid to light of an appropriate wavelength to damage the nucleic acid of the pathogen and to substantially maintain the damage to the pathogenic nucleic acids to allow for subsequent transfusion into a recipient.Type: GrantFiled: August 25, 2003Date of Patent: March 8, 2011Assignee: CaridianBCT Biotechnologies, LLCInventors: Robert Owen Lockerbie, Vijay Kumar, Shawn D. Keil, Raymond P. Goodrich
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Patent number: 7892535Abstract: This invention is directed toward a process for reducing transfusion related complications in a recipient of an allogeneic blood transfusion by adding to the blood to be transfused a photosensitizer comprising riboflavin, irradiating the blood and riboflavin with light, transfusing the irradiated blood into a recipient, and reducing a transfusion related complication by the recipient to cells in the donor blood. The invention is also directed towards a process for preventing rejection of a donor organ by a recipient comprising the steps of transfusing the recipient of the donor organ with treated platelets; and transplanting the donor organ into the recipient.Type: GrantFiled: December 3, 2009Date of Patent: February 22, 2011Assignee: CaridianBCT Biotechnologies, LLCInventors: Raymond P. Goodrich, Junzhi Li
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Patent number: 7789847Abstract: A method and apparatus for red blood collection and filtration is provided wherein a red blood cell collection assembly provides for leukoreduction filtration concurrent with or soon after the red blood cell separation and collection procedure. Such procedures involve filtering the separated red blood cells in a diluted state after and/or prior to flushing the filter with storage solution. Storage solution may thus be passed through the leukoreduction filter before, with and/or after the RBCs have been filtered therethrough. The red blood cell collection, filtration and storage assembly is preferably preconnected to a blood component separation disposable assembly, including, for example, a centrifuge vessel and a blood removal/return assembly for removing blood from a donor, passing the blood to the centrifuge vessel for separation of the blood into components for collection and providing for filtration of the separated red blood cell component.Type: GrantFiled: August 21, 2007Date of Patent: September 7, 2010Assignee: CaridianBCT, Inc.Inventors: Bruce W. Gibbs, Jon Herskovits
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Patent number: 7686779Abstract: A preconnected disposable and method for red blood collection is provided wherein the preconnected disposable includes a red blood cell collection assembly comprising a leukoreduction filter and a red blood cell storage bag. Such a red blood cell collection assembly is preferably preconnected to a blood component separation vessel, cassette assembly and a blood removal/return assembly for removing blood from a donor, separating the blood into components for collection and providing for filtration of the separated red blood cell component.Type: GrantFiled: September 27, 2000Date of Patent: March 30, 2010Assignee: Caridian BCT, IncInventor: Bruce W. Gibbs
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Patent number: 7682329Abstract: A method and apparatus for red blood collection and filtration is provided wherein a red blood cell collection assembly provides for leukoreduction filtration concurrent with or soon after the red blood cell separation and collection procedure. Such procedures involve filtering the separated red blood cells in a diluted state after and/or prior to flushing the filter with storage solution. Storage solution may thus be passed through the leukoreduction filter before, with and/or after the RBCs have been filtered therethrough. The red blood cell collection, filtration and storage assembly is preferably preconnected to a blood component separation disposable assembly, including, for example, a centrifuge vessel and a blood removal/return assembly for removing blood from a donor, passing the blood to the centrifuge vessel for separation of the blood into components for collection and providing for filtration of the separated red blood cell component.Type: GrantFiled: April 6, 2006Date of Patent: March 23, 2010Assignee: CaridianBCT, Inc.Inventors: Bruce W. Gibbs, Jon Herskovits
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Patent number: 7651474Abstract: A method and apparatus for red blood collection and filtration is provided wherein a red blood cell collection assembly provides for leukoreduction filtration concurrent with or soon after the red blood cell collection procedure. The procedure preferably involves filtering the separated red blood cells in a high hematocrit (high-crit) state prior to addition of storage solution thereto. Preferably, a storage solution is passed through the leukoreduction filter after the RBCs have been filtered therethrough. The red blood cell collection filtration and storage assembly is preferably preconnected to a blood component separation disposable assembly, including, for example, a centrifuge vessel and a blood removal/return assembly for removing blood from a donor, passing the blood to the centrifuge vessel for separation of the blood into components for collection and providing for filtration of the separated red blood cell component, as described.Type: GrantFiled: June 3, 2004Date of Patent: January 26, 2010Assignee: CaridianBCT, Inc.Inventors: Geert Van Waeg, Bruce W. Gibbs, Marc Antoon, Laura Goodrich
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Patent number: 7648699Abstract: This invention is directed toward a process for reducing transfusion related complications in a recipient of an allogeneic blood transfusion by adding to the blood to be transfused a photosensitizer comprising riboflavin, irradiating the blood and riboflavin with light, transfusing the irradiated blood into a recipient, and reducing a transfusion related complication by the recipient to cells in the donor blood. The invention is also directed towards a process for preventing rejection of a donor organ by a recipient comprising the steps of transfusing the recipient of the donor organ with treated platelets; and transplanting the donor organ into the recipient.Type: GrantFiled: August 31, 2006Date of Patent: January 19, 2010Assignee: CaridianBCT Biotechnologies, LLCInventors: Raymond P. Goodrich, Junzhi Li
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Patent number: 7201848Abstract: The present invention is directed to a method and system that separates first particles from second particles, or white blood cells from red blood cells, by sedimentation in a fluid chamber with debulking of one of the first or second particles or red blood cells through the inlet of the fluid chamber. The method and system further includes fractionation of the remaining particles or white blood cells into selected subsets. In one embodiment of the instant invention a blood product containing white blood cells is loaded in a separation chamber, a diluting or sedimenting agent is added to encourage rouleaux formation of any red blood cells, the cells are sedimented and the red blood cells are removed.Type: GrantFiled: December 4, 2002Date of Patent: April 10, 2007Assignee: Gambro BCT, Inc.Inventors: Glen Delbert Antwiler, Linda A. Taylor
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Patent number: 7186543Abstract: Methods are provided for treating a vaccine containing infectious particles which may be viral, bacterial, and/or cellular in nature. Preferred methods include the steps of adding an effective, non-toxic amount of an endogenous photosensitizer to the fluid and exposing the fluid to photoradiation sufficient to inactivate the infectious particles but not enough to damage the antigenic characteristics of the infectious particles.Type: GrantFiled: December 20, 2002Date of Patent: March 6, 2007Assignee: Gambro Inc.Inventor: Raymond P. Goodrich
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Patent number: 7183045Abstract: The methods of this invention involve preventing the formation of a complex between adenine and riboflavin by reducing the amount of adenine in a solution containing blood or blood components to be pathogen reduced.Type: GrantFiled: April 24, 2003Date of Patent: February 27, 2007Assignee: Gambro Inc.Inventors: Raymond P. Goodrich, Suzann K. Doane
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Patent number: 7077559Abstract: A mixing system, apparatus and/or method. Pathogen reduction of and/or mixing storage solutions into blood or blood components are useful purposes for these. Squeezing or clapping devices may be used to activate the mixing process, as may rotational devices or laterally movable, rotational and/or orbital devices. Constriction elements may also be used to create useful vortex mixing actions. Photoradiation may be provided while the components continue to be mixed together for pathogen reduction of blood or blood components.Type: GrantFiled: April 28, 2003Date of Patent: July 18, 2006Assignee: Gambro, Inc.Inventors: Dennis J. Hlavinka, Michael A. Martinez
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Patent number: D544103Type: GrantFiled: April 10, 2006Date of Patent: June 5, 2007Assignee: Gambro Lundia ABInventor: Cyril Meziere
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Patent number: D550373Type: GrantFiled: April 10, 2006Date of Patent: September 4, 2007Assignee: Gambro Lundia ABInventor: Cyril Meziere