Patents Represented by Attorney, Agent or Law Firm Laura J. Fischer
  • Biologically active Eph family ligands
    Patent number: 6602683
    Abstract: A novel ligand (Efl-6) that binds the Elk subfamily of Eph receptors is identified, and methods for making the soluble Elf-6 ligand in biologically active form is described. A cDNA clone encoding this novel protein enables production of the recombinant protein, which is useful to support neuronal and other eph receptor-bearing cell populations.
    Type: Grant
    Filed: April 24, 1998
    Date of Patent: August 5, 2003
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Samuel Davis, Nicholas W. Gale, George D. Yancopoulos
  • Nucleic acids encoding a modified ciliary neurotrophic factor and method of making thereof
    Patent number: 6472178
    Abstract: Modified ciliary neurotrophic factor, methods for production and methods of use, especially in the treatment of Huntington's disease, obesity, and gestational or adult onset diabetes.
    Type: Grant
    Filed: February 27, 1998
    Date of Patent: October 29, 2002
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: James P. Fandl, Neil E. Stahl, Stanley J. Wiegand
  • Nucleic acids encoding modified ciliary neurotrophic factors
    Patent number: 6440702
    Abstract: Modified ciliary neurotrophic factors and methods for their production and therapeutic use. Also described is a method of screening for novel therapeutic proteins by determining altered electrophoretic binding properties.
    Type: Grant
    Filed: November 20, 1998
    Date of Patent: August 27, 2002
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventor: Nikos Panayotatos