Abstract: The present invention discloses the identification of the inhibitors of IMPDH (inosine-5′-monophosphate dehydrogenase). The compounds and pharmaceutical compositions disclosed herein are useful in treating or preventing IMPDH associated disorders, such as transplant rejection and autoimmune diseases.
Type:
Grant
Filed:
October 27, 1999
Date of Patent:
September 23, 2003
Assignee:
Bristol-Myers Squibb Company
Inventors:
Henry H. Gu, T. G. Murali Dhar, Edwin J. Iwanowicz