Patents Represented by Attorney, Agent or Law Firm Lauren L. Stevens, Esq.
  • Database system including computer code for predictive cellular bioinformatics
    Patent number: 6651008
    Abstract: According to the present invention, computer based techniques for using information technology in therapeutics or drug discovery. In an exemplary embodiment, computer based techniques for determining information about the properties of substances based upon information about structure of living or non-living cells exposed to substances are provided. Computer software according to the present invention enables researchers and/or scientists to identify promising candidates in the search for new and better medicines or treatments using, for example, a cellular informatics database.
    Type: Grant
    Filed: November 21, 2000
    Date of Patent: November 18, 2003
    Assignee: Cytokinetics, Inc.
    Inventors: Eugeni A. Vaisberg, Cynthia L. Adams, James H. Sabry, Anne M. Crompton
  • Methods of screening for modulators of cell proliferation
    Patent number: 6617115
    Abstract: Described herein are methods that can be used for diagnosis and prognosis of cellular proliferation. Also described herein are methods that can be used to screen candidate bioactive agents for the ability to modulate cellular proliferation. Additionally, methods and molecular targets (genes and their products) for therapeutic intervention in cancers are described.
    Type: Grant
    Filed: October 27, 1999
    Date of Patent: September 9, 2003
    Assignee: Cytokinetics, Inc.
    Inventors: Kenneth W. Wood, Jeffrey T. Finer, Christophe Beraud, John Mak, Roman Sakowicz
  • Motor proteins and methods for their use
    Patent number: 6610525
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of HsKifC2, antibodies to HsKifC2, methods of screening for HsKifC2 modulators using biologically active HsKifC2, and kits for screening for HsKifC2 modulators.
    Type: Grant
    Filed: November 22, 2000
    Date of Patent: August 26, 2003
    Assignee: Cytokinetics, Inc.
    Inventors: Christophe Beraud, Richard Freedman
  • Motor proteins and methods for their use
    Patent number: 6562610
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of HsKif7, antibodies to HsKif7, methods of screening for HsKif7 modulators using biologically active HsKif7, and kits for screening for HsKif7 modulators.
    Type: Grant
    Filed: November 27, 2000
    Date of Patent: May 13, 2003
    Assignee: Cytokinetics, Inc.
    Inventors: Christophe Beraud, Richard Freedman
  • Motor proteins and methods for their use
    Patent number: 6551787
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of HsKif7, antibodies to HsKif7, methods of screening for HsKif7 modulators using biologically active HsKif7, and kits for screening for HsKif7 modulators.
    Type: Grant
    Filed: November 27, 2000
    Date of Patent: April 22, 2003
    Assignee: Cytokinetics, Inc.
    Inventors: Christophe Beraud, Richard Freedman
  • Motor proteins and methods for their use
    Patent number: 6548267
    Abstract: The present invention provides high throughput screening systems for identifying compounds useful in the treatment of cellular proliferation disorders. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: April 15, 2003
    Assignee: Cytokinetics, Inc.
    Inventor: Christophe Beraud
  • Human kinesins and methods of producing and purifying human kinesins
    Patent number: 6544766
    Abstract: Described herein are methods of producing kinesins. In a preferred embodiment, the kinesins are produced from a prokaryote, most preferably, a bacterial cell. Bacterial expression offers several advantages over systems previously utilized, such as, for example, Bacculovirus. The yield of protein is higher, the cost of the expression setup is lower, and creation of alternative expression vectors is easier. The concern of copurifying a contaminating activity from the expression host is also eliminated since bacteria, in contrast to the bacculovirus expression system, do not have kinesin like proteins. Also described herein are purified kinesins, preferably unglycosylated and methods of use.
    Type: Grant
    Filed: June 16, 2000
    Date of Patent: April 8, 2003
    Assignee: Cytokinetics, Inc.
    Inventors: Christophe Beraud, Cara Ohashi, Roman Sakowicz, Eugeni Vaisberg, Ken Wood, Ming Yu
  • Antifungal assay
    Patent number: 6468760
    Abstract: The present invention provides high throughput screening systems for identifying antifungal compounds. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: October 22, 2002
    Assignee: Cytokinetics, Inc.
    Inventors: Corey E. Nislow, Roman Sakowicz, Christophe Beraud
  • Human kinesin-like protein HSKIF21B
    Patent number: 6455293
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of HsKif21b, antibodies to HsKif21b, methods of screening for HsKif21b modulators using biologically active HsKif21b, and kits for screening for HsKif21b modulators.
    Type: Grant
    Filed: November 22, 2000
    Date of Patent: September 24, 2002
    Assignee: Cytokinetics, Inc.
    Inventors: Christophe Beraud, Richard Freedman
  • Screening assays for modulators of human kinesin protein HsKrp5
    Patent number: 6448026
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of HsKrp5, antibodies to HsKrp5, methods of screening for HsKrp5 modulators using biologically active HsKrp5, and kits for screening for HsKtp5 modulators.
    Type: Grant
    Filed: November 27, 2000
    Date of Patent: September 10, 2002
    Assignee: Cytokinetics, Inc.
    Inventors: Christophe Beraud, Richard Freedman
  • Motor proteins and methods for their use
    Patent number: 6448025
    Abstract: The present invention provides high throughput screening systems for identifying compounds useful in the treatment of cellular proliferation disorders. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.
    Type: Grant
    Filed: June 15, 2000
    Date of Patent: September 10, 2002
    Assignee: Cytokinentics, Inc.
    Inventors: Eugeni A. Vaisberg, Kenneth W. Wood, Christophe Beraud
  • Methods of identifying modulators of kinesin motor proteins
    Patent number: 6440684
    Abstract: The present invention provides high throughput screening systems for identifying compounds useful in the treatment of cellular proliferation disorders. The method can be performed in plurality simultaneously with fluorescence or absorbance readouts.
    Type: Grant
    Filed: June 12, 2000
    Date of Patent: August 27, 2002
    Assignee: Cytokinetics, Inc.
    Inventors: Christophe Beraud, Jeffrey T. Finer, Roman Sakowicz, Kenneth W. Wood
  • Screening assays for modulators of human kinesin protein HsKif16b
    Patent number: 6440685
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of HsKif16b, antibodies to HsKif16b, methods of screening for HsKif16b modulators using biologically active HsKif16b, and kits for screening for HsKif16b modulators.
    Type: Grant
    Filed: November 24, 2000
    Date of Patent: August 27, 2002
    Assignee: Cytokinetics, Inc.
    Inventors: Christophe Beraud, Richard Freedman
  • Polynucleotides encoding HsKrp5 a kinesin related protein
    Patent number: 6440731
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of HsKrp5, antibodies to HsKrp5, methods of screening for HsKrp5 modulators using biologically active HsKrp5, and kits for screening HsKrp5 modulators.
    Type: Grant
    Filed: August 17, 2000
    Date of Patent: August 27, 2002
    Assignee: Cytokinetics, Inc.
    Inventors: Christophe Beraud, Richard Freedman
  • Methods for screening and therapeutic applications of kinesin modulators
    Patent number: 6440686
    Abstract: The present invention relates to protein modulators, especially modulators of kinesin bioactivities. The present invention provides methods for screening protein modulators, e.g., kinesin modulators that bind to a region of a kinesin and/or that modulate kinesin bioactivities. The present invention also provide methods and compositions for treatment of disorders mediated by abnormal cellular proliferation activities.
    Type: Grant
    Filed: June 15, 2000
    Date of Patent: August 27, 2002
    Assignee: Cytokinetics, Inc.
    Inventor: Roman Sakowicz
  • Nucleic acids encoding KSP, a kinesin motor protein
    Patent number: 6437115
    Abstract: Described herein are methods that can be used for diagnosis and prognosis of cellular proliferation. Also described herein are methods that can be used to screen candidate bioactive agents for the ability to modulate cellular proliferation. Additionally, methods and molecular targets (genes and their products) for therapeutic intervention in cancers are described.
    Type: Grant
    Filed: June 12, 2000
    Date of Patent: August 20, 2002
    Assignee: Cytokinetics, Inc.
    Inventors: Kenneth W. Wood, Jeffrey T. Finer, Christophe Beraud, John Mak, Roman Sakowicz
  • Motor proteins and methods for their use
    Patent number: 6432660
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of HsKif12a, antibodies to HsKif12a, methods of screening for HsKif12a modulators using biologically active HsKif12a, and kits for screening for HsKif12a modulators.
    Type: Grant
    Filed: November 27, 2000
    Date of Patent: August 13, 2002
    Assignee: Cytokinetics, Inc.
    Inventors: Christophe Beraud, Richard Freedman
  • Motor proteins and methods for their use
    Patent number: 6429005
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of HsKif12a, antibodies to HsKif12a, methods of screening for HsKif12a modulators using biologically active HsKif12a, and kits for screening for HsKif12a modulators.
    Type: Grant
    Filed: August 3, 2000
    Date of Patent: August 6, 2002
    Assignee: Cytokinetics, Inc.
    Inventors: Christophe Beraud, Richard Freedman
  • Motor proteins and methods for their use
    Patent number: 6426207
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of HsKif12a, antibodies to HsKif12a, methods of screening for HsKif12a modulators using biologically active HsKif12a, and kits for screening for HsKif12a modulators.
    Type: Grant
    Filed: November 27, 2000
    Date of Patent: July 30, 2002
    Assignee: Cytokinetics, Inc.
    Inventors: Christophe Beraud, Richard Freedman
  • Screening assays for modulators of human kinesin protein HsKif21b
    Patent number: 6426193
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of HsKif21b, antibodies to HsKif21b, methods of screening for HsKif21b modulators using biologically active HsKif21b, and kits for screening for HsKif21b modulators.
    Type: Grant
    Filed: November 22, 2000
    Date of Patent: July 30, 2002
    Assignee: Cytokinetics, Inc.
    Inventors: Christophe Beraud, Richard Freedman