Patents Represented by Law Firm Law Office of Margit Maus
  • Artificial pancreas
    Patent number: 6399341
    Abstract: An artificial pancreas is described herein which comprises one or more viable and physiologically active pancreatic islet cells capable of producing insulin, encapsulated within a semipermeable spheroidal membrane comprising agar gel. Further disclosed are a method for producing agar microbeads, a tissue implantation method and a reseeding method for the artificial pancreas.
    Type: Grant
    Filed: November 2, 1999
    Date of Patent: June 4, 2002
    Inventors: Jan Philip Stegemann, John Joseph O'Neil, Claudy Jean Paul Mullon
  • Method of cryopreserving hepatocytes
    Patent number: 6136525
    Abstract: An artificial liver support system is described herein which comprises cryopreserved hepatocytes having an initial viability of 80-99%. Further disclosed are hepatocytes cryopreserved by dispensing hepatocytes into freezing containers, freezing the containers from between minus 50 to minus 90 degrees Celsius, storing the containers in liquid or vapor nitrogen, thawing the cryopreserved hepatocytes when ready for use and removing residual cryoprotectant media.
    Type: Grant
    Filed: August 2, 1999
    Date of Patent: October 24, 2000
    Assignee: Circe Biomedical, Inc.
    Inventors: Claudy Jean-Paul Mullon, Shawn Paul Cain, Timothy Jon Perlman, Hugo O. Jauregui, Sharda Naik, Henry A. Santangini, Donna M. Trenkler
  • Cryopreserved hepatocytes and high viability and metabolic activity
    Patent number: 5795711
    Abstract: An artificial liver support system is described herein which comprises cryopreserved hepatocytes having an initial viability of 80-99% and a metabolic activity 50-80% of fresh hepatocytes. Further disclosed are hepatocytes cryopreserved by dispensing hepatocytes into freezing containers, freezing the containers from between minus 50 to minus 90 degrees Celsius, storing the containers in liquid or vapor nitrogen, thawing the cryopreserved hepatocytes when ready for use and removing residual cryoprotectant media.
    Type: Grant
    Filed: April 4, 1996
    Date of Patent: August 18, 1998
    Assignee: Circe Biomedical, Inc.
    Inventors: Claudy Jean-Paul Mullon, Shawn Paul Cain, Timothy Jon Perlman, Hugo O. Jauregui, Sharda Naik, Henry A. Santangini, Donna M. Trenkler