Abstract: A multifunctional clip applier instrument includes an elongate instrument body having a proximal end received in a control housing, a distal end having one or two pairs of opposed forceps jaws spring biased apart, a plurality of surgical clips disposed in one or two clip magazines inserted into a clip cartridge removably received into the instrument body and a handle cooperating with the control housing to operate the forceps jaws to apply clips to tissue, to grasp and manipulate tissue when no clip is in the jaws, to selectively or automatically advance clips into the jaws and to selectively or automatically cut tissue after clipping.