Abstract: A skew slit collimator for a gamma ray imaging device and a method of configuring the skew slit collimator for a gamma ray imaging device is disclosed. The gamma ray imaging device includes a detector having a generally planar detector surface. The detector surface is operable to be positioned adjacent a subject imaging region. The skew slit collimator includes a first collimator blade having a first slit and a second collimator blade having a second slit. The first collimator blade is disposed in front of and generally parallel to the detector surface. The second collimator blade is disposed between the first collimator blade and the detector surface. The second collimator is generally parallel to and spaced apart from the first collimator blade. The second collimator blade is oriented with respect to the first collimator blade such that the lengthwise orientation of the second slit is generally orthogonal to a lengthwise orientation of the first slit.