Patents Represented by Attorney, Agent or Law Firm Law Ofices of Jonathan Alan Quine
  • Methods for recombining nucleic acids
    Patent number: 6344356
    Abstract: A method for DNA reassembly after random fragmentation, and its application to mutagenesis of nucleic acid sequences by in vitro or in vivo recombination is described. In particular, a method for the production of nucleic acid fragments or polynucleotides encoding mutant proteins is described. The present invention also relates to a method of repeated cycles of mutagenesis, shuffling and selection which allow for the directed molecular evolution in vitro or in vivo of proteins.
    Type: Grant
    Filed: June 8, 2000
    Date of Patent: February 5, 2002
    Assignee: Maxygen, Inc.
    Inventor: Willem P.C. Stemmer