Patents Represented by Attorney Lawrence Berkely National Laboratory

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  • Apolipoprotein A-I mutant proteins having cysteine substitutions and polynucleotides encoding same
    Patent number: 7223726
    Abstract: Functional Apolipoprotein A-I mutant proteins, having one or more cysteine substitutions and polynucleotides encoding same, can be used to modulate paraoxonase's arylesterase activity. These ApoA-I mutant proteins can be used as therapeutic agents to combat cardiovascular disease, atherosclerosis, acute phase response and other inflammatory related diseases. The invention also includes modifications and optimizations of the ApoA-I nucleotide sequence for purposes of increasing protein expression and optimization.
    Type: Grant
    Filed: January 14, 2003
    Date of Patent: May 29, 2007
    Assignee: The Regents of the University of California
    Inventors: Michael N. Oda, Trudy M. Forte