Patents Represented by Attorney, Agent or Law Firm Lawrence Martin
  • Drechsleranol derivatives, processes for their preparation and their use
    Patent number: 6794408
    Abstract: The present invention provides novel drechsleranol compounds of formula (I) which are formed by the microorganism Drechslera australlensis, ST 003360, DSM 14093, or a fungus ST 004112, DSM 14524, during fermentation. A process for their preparation, pharmaceutical compositions containing said drechsleranols their use for the treatment and/or prophylaxis of degenerative neuropathies, such as, Alzheimeu's disease, or psychiatric disorders, such as depression, sleep disturbance or seasonal affective disorder, and their use as chelating agents or antioxidants are also disclosed and claimed.
    Type: Grant
    Filed: January 27, 2003
    Date of Patent: September 21, 2004
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Claudia Eder, Michael Kurz, Luigi Toti
  • Process for the preparation of combretastatins
    Patent number: 6759555
    Abstract: The present invention provides novel processes for the preparation of combretastatins or stilbene compounds of formulae (I) and (III) wherein A is NH2 or and PG is a protecting group.
    Type: Grant
    Filed: April 9, 2003
    Date of Patent: July 6, 2004
    Assignee: Aventis Pharma S.A.
    Inventors: Stéphane Mutti, Michel Lavigne, Irina Malejonock, Jean-Paul Casimir
  • Pseudopolymorph of (—)-cis-2-(2-chlorophenyl)-5,7-dihydroxy-8[4R-(3S-hydroxy -1-methyl)piperidinyl]-4H-1-benzopyran-4-one
    Patent number: 6576647
    Abstract: The present invention comprises a pseudopolymorph of (−)-cis-2-(2-chlorophenyl)-5,7-dihydroxy-8[4R-(3S-hydroxy-1-methyl)piperidinyl]-4H-1-benzopyran-4-one hydrochloride, a method of making same, a pharmaceutical composition and methods of using the pseudopolymorph.
    Type: Grant
    Filed: January 16, 2001
    Date of Patent: June 10, 2003
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: Gary L. Bafus, Christine M. Harrison-Bowman, Gary Lee Silvey