Abstract: A baculovirus transfer vector incorporates a restriction site into which a foreign gene may be cloned a short distance downstream of the N-terminus of the polyhedrin gene body and the natural ATG translation start codon for the polyhedrin gene is not provided such that the N-terminal polyhedrin coding sequence prior to the restriction site is retained but not capable of being translated.
Abstract: A method of treating idiopathic thrombocytopaenia purpura with 2',3'-dideoxy-3'-azidonucleosides, in particular 3'-azido-3'-deoxythymidine, is disclosed.
Type:
Grant
Filed:
April 2, 1991
Date of Patent:
September 8, 1992
Assignee:
Burroughs Wellcome Co.
Inventors:
Leone E. Kirk, III, Dannie H. King, Richard H. Clemons, Sandra N. Lehrman, David W. Barry