Patents Represented by Attorney Lawrence S. Levinson
  • Patent number: 4842857
    Abstract: Cultivation of a strain of the microorganism Micromonospora sp. A.T.C.C. No. 53481, yields the novel antibiotic substance glyphomicin, which is a mixture of glyphomicin A and glyphomicin B.
    Type: Grant
    Filed: May 12, 1986
    Date of Patent: June 27, 1989
    Assignee: E. R. Squibb and Sons, Inc.
    Inventors: Edward Meyers, William L. Parker
  • Patent number: 4834096
    Abstract: A polymeric, surgical clip having first and second curved leg members joined at their proximal end by a reduced thickness hinge portion and movable from an open position to a closed position for clamping a vessel between curved opposing inner surfaces which are substantially parallel when the clip is closed. The first leg member has a concave inner surface and a hook portion at its distal end curved toward the second leg member. A ligating clip applying instrument for applying the clip has a pair of handles pivoted about a hinge point and extends beyond the hinge point to form a pair of clip closing jaws equipped with means for engaging bosses located on the sides of the first and second leg members.
    Type: Grant
    Filed: June 13, 1988
    Date of Patent: May 30, 1989
    Assignee: Edward Weck Incorporated
    Inventors: Seik Oh, Ray McKinney, Jr.
  • Patent number: 4834732
    Abstract: A three part ostomy coupling has a first part having a flange, a central chute and an array of space projections. A second part has a peripheral seal for engaging and surrounding the outer wall of the chute an outwardly projecting rim which can be snap fitted on the space projection. A third part is rotatable to effect a positive lock between the rim the projections, for example by deforming the projections inwardly.
    Type: Grant
    Filed: July 9, 1987
    Date of Patent: May 30, 1989
    Assignee: E. R. Squibb and Sons, Inc.
    Inventors: Peter L. Steer, Neil P. Wiltshire
  • Patent number: 4829999
    Abstract: The guidewire gripping device is usable in connection with guidewires of the type used in medical application, i.e., for guiding catheters. The guidewire gripping device is constructed from a spring loaded, slitted cylindrical body.
    Type: Grant
    Filed: July 17, 1987
    Date of Patent: May 16, 1989
    Assignee: E. R. Squibb and Sons, Inc.
    Inventor: David C. Auth
  • Patent number: 4828797
    Abstract: A biological test pack adapted for use in testing the efficacy of an ethylene oxide sterilization process is described. The test pack is a clear plastic tray containing an sterilization sensitive ink which has been imprinted on a card which faces out of the bottom of the plastic tray. In addition, the tray contains a plastic syringe which holds a biological indicator. On top of the plastic syringe, absorbent paper is placed. The entire pack has a Tyvek sheet which seals it until it is used. The plastic tray is molded into a shape for holding the various items in particularly desirable locations. Accordingly, a disposable test pack which is uniformly manufactured and which should yield consistent results, is described. It can be used either as a general purpose routine test pack or as a validation challenge test pack.
    Type: Grant
    Filed: June 24, 1986
    Date of Patent: May 9, 1989
    Assignee: Edward Weck Incorporated
    Inventors: Andrew A. Zwarun, Steven T. Buglino
  • Patent number: 4826496
    Abstract: An ostomy device for releasably connecting an ostomy bag to an adhesive backed label including a mounting member for connecting one of two coupling parts to the label. The mounting member comprises an expandable portion for facilitating displacement of the connected coupling part between a normal position and an expanded position. The expanded portion comprises a pair of accordion-like folds including an inner fold and a smaller outer fold. The connected coupling part comprises a rib portion having a deflectible sealing strip extending therefrom. The rib portion is connected to the mounting member adjacent the outer folds such that the sealing strip is positioned intermediate the inner and outer folds when the coupling part is in the normal position. The inner fold guides discharge from the stoma into the bag and away from the interengaged coupling parts. In an alternate embodiment, the mounting member is affixed to the label.
    Type: Grant
    Filed: February 6, 1987
    Date of Patent: May 2, 1989
    Assignee: E. R. Squibb and Sons, Inc.
    Inventor: Keith T. Ferguson
  • Patent number: 4824831
    Abstract: Compound of the formula ##STR1## wherein R.sub.3 is aryl and R.sub.1 is hydrogen or ##STR2## are disclosed. These compounds are useful as cardiovascular agents, and especially as anti-hypertensive agents.
    Type: Grant
    Filed: December 21, 1987
    Date of Patent: April 25, 1989
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Karnail Atwal
  • Patent number: 4822347
    Abstract: An incontinence device for females is intended for long term wear. It includes a tubular sheath integral with a funnel and a urine-conducting pipe. The sheath is secured to a pad of adhesive material having a central hole leading into the interior of the sheath. The pad is dimensioned so that it can be stuck to the skin of the wearer in the region immediately surrounding the urethral orifice (meatus).
    Type: Grant
    Filed: December 31, 1981
    Date of Patent: April 18, 1989
    Assignee: E. R. Squibb and Sons, Inc.
    Inventor: Morag M. MacDougall
  • Patent number: 4820733
    Abstract: A method is provided for preventing or reducing platelet loss during extracorporeal circulation, such as during coronary artery bypass or graft surgery by administering a thromboxane A.sub.2 antagonist alone or with prostacyclin and/or a prostacyclin mimic.
    Type: Grant
    Filed: March 7, 1988
    Date of Patent: April 11, 1989
    Assignee: E.R. Squibb & Sons, Inc.
    Inventor: Gary J. Grover
  • Patent number: 4820285
    Abstract: The bayonet coupling uses a body side flange and a bag side flange. The body side flange has L-shaped openings engaged to engage with pins on the body side flange. The body side flange includes an annular detent which includes an O-ring for sealing purposes.
    Type: Grant
    Filed: September 16, 1987
    Date of Patent: April 11, 1989
    Assignee: E.R. Squibb & Sons, Inc.
    Inventors: Walter F. Leise, Kenneth A. Johnsen
  • Patent number: 4818757
    Abstract: Compounds of the formula ##STR1## are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their enkephalinase inhibition activity.
    Type: Grant
    Filed: December 28, 1987
    Date of Patent: April 4, 1989
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Harold N. Weller, III, Eric M. Gordon
  • Patent number: 4816023
    Abstract: The present invention is an improved coupling for as ostomy bag system. In the improved coupling, an integral O-ring is included to improve the retention of the coupling as well as its seal by extending through the annular ring.
    Type: Grant
    Filed: November 16, 1987
    Date of Patent: March 28, 1989
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Frank M. Freeman
  • Patent number: 4816579
    Abstract: A process is provided for preparing a 7-oxabicycloheptane amino alcohol intermediate of the general structure ##STR1## (wherein the above structure represents (D) of (L) isomers) which is useful in preparing thromboxane A.sub.2 receptor antagonists. This intermediate is prepared by reacting mesoanhydride with an aryl amine ##STR2## wherein R is alkyl, CH.sub.2 OH, CO.sub.2 H or CO.sub.2 alkyl, to form the acid ##STR3## which is reduced by treatment with lithium aluminum hydride or diisobutylaluminum hydride or Red-Al to form the alcohol ##STR4## wherein R.sup.1 is CH.sub.2 OH when R is CO.sub.2 H, CO.sub.2 alkyl or CH.sub.2 OH, and R.sup.1 is alkyl; where in the above alcohol R.sup.1 is CH.sub.2 OH, such alcohol compound is treated with an alkyl chloroformate in the presence of base such as an alkali metal alkoxide to form the alcohol ##STR5## which undergoes cleavage by treatment with alkali metal, ammonia and acid to form the amino alcohol intermediate.Where in the above alcohol R.sup.
    Type: Grant
    Filed: January 27, 1988
    Date of Patent: March 28, 1989
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: John K. Thottathil
  • Patent number: 4814454
    Abstract: p-Aminophenols are provided having the structure ##STR1## wherein m is 0 to 5; X is CH or N; R.sup.1 and R.sup.2 may be the same or different and are H, lower alkyl, aryl, hydroxy, hydroxyalkyleneoxy, alkylthio, alkoxy, alkanoyloxy, aryloxy, halo, carboxy, alkoxycarbonyl or amido; R.sup.3 is H, lower alkyl, alkanoyl or aroyl; and R.sup.4 is H, lower alkyl or alkanoyl, and including acid-addition salts thereof, with the proviso that when X is CH, m is 0 and R.sup.1 is H, and when R.sup.4 is H, R.sup.2 is other than alkoxy, H or hydroxy, and when R.sup.4 is benzoyl, R.sup.2 is other than H.These compounds together with the compounds defined in the above proviso are useful as inhibitors of leukotriene production and as such are useful as antiallergy, anti-inflammatory and anti-psoriatic agents.
    Type: Grant
    Filed: June 22, 1987
    Date of Patent: March 21, 1989
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Raj N. Misra
  • Patent number: 4812564
    Abstract: Disclosed herein is a process for preparing a compound having the formula ##STR1## which comprises sulfonating a compound having the formula ##STR2## with a complex having the formula ##STR3## and cyclizing the resulting compound having the formula ##STR4## by treatment with a base.
    Type: Grant
    Filed: May 11, 1987
    Date of Patent: March 14, 1989
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: William A. Slusarchyk, Tamara Dejneka
  • Patent number: 4810791
    Abstract: Compounds of the formula ##STR1## are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definintion of X may also be useful as analgesics due to their enkephalinase inhibition activity.
    Type: Grant
    Filed: December 28, 1987
    Date of Patent: March 7, 1989
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Harold N. Weller, III, Eric M. Gordon
  • Patent number: H642
    Abstract: Compounds of the formula ##STR1## wherein X is various imino or amino acids or esters are disclosed. These compounds possess angiotensin converting enzyme inhibition activity and depending upon the definition of X also possess enkephalinase inhibition activity.
    Type: Grant
    Filed: August 20, 1984
    Date of Patent: June 6, 1989
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: David Floyd, Melanie J. Loots
  • Patent number: D302306
    Type: Grant
    Filed: January 7, 1987
    Date of Patent: July 18, 1989
    Assignee: E. R. Squibb and Sons, Inc.
    Inventor: Peter L. Steer
  • Patent number: D302307
    Type: Grant
    Filed: January 7, 1987
    Date of Patent: July 18, 1989
    Assignee: E. R. Squibb and Sons, Inc.
    Inventor: Peter L. Steer
  • Patent number: RE33072
    Abstract: Vasodilating activity is exhibited by compounds having the formula ##STR1## n is 2 or 3; X is oxygen or sulfur,R.sub.1 and R.sub.2 are each independently hydrogen alkyl, cycloalkyl, or allyl, or R.sub.1 and R.sub.2 together with the nitrogen atom to which they are attached are pyrrolidinyl, piperidinyl, or morpholinyl;R.sub.3 is alkyl, alkoxy, halogen, trifluoromethyl, or nitro;R.sub.4 is hydrogen, halogen, trifluoromethyl, or nitro; andR.sub.5 and R.sub.6 are each independently alkyl or cycloalkyl or R.sub.5 and R.sub.6 together with the nitrogen atom to which they are attached are pyrrolidinyl, piperidinyl, or morpholinyl.
    Type: Grant
    Filed: July 8, 1988
    Date of Patent: September 26, 1989
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: David Floyd, John Krapcho