Abstract: The process of the present invention relates to a process for producing 1 3-cis retinoic acid. The process of the present invention involves reacting a Wittig salt in a solvent with a butenolide in the presence of a weak base and a Lewis acid.
Type:
Grant
Filed:
March 25, 1998
Date of Patent:
September 26, 2000
Assignee:
Abbott Laboratories
Inventors:
Xiu C. Wang, Ashok V. Bhatia, Azad Hossain, Timothy B. Towne