Patents Represented by Attorney, Agent or Law Firm Lee K. Tan
  • Anti-tumor antibody compositions and methods of use
    Patent number: 7435416
    Abstract: The invention provides antibodies targeted at a tumor antigen prevalent on prostate tumors and methods useful in alleviating cancers expressing the antigen, as well as nucleic acids and cells for expressing the antibodies.
    Type: Grant
    Filed: September 8, 2004
    Date of Patent: October 14, 2008
    Assignee: Genetech, Inc.
    Inventors: Brigitte Devaux, Gilbert-Andre Keller, Hartmut Koeppen, Lawrence A. Lasky
  • Method of treating granuloma annulare or sarcoid
    Patent number: 7396530
    Abstract: The invention provides a method of alleviating a granuloma annulare or a sarcoid disease by administering to a patient having the disease, a therapeutically effective amount of an LFA-1 antagonist.
    Type: Grant
    Filed: June 8, 2005
    Date of Patent: July 8, 2008
    Assignee: Genentech, Inc.
    Inventor: Bernard S. Goffe
  • Treatment of LFA-1 associated disorders with increasing doses of LFA-1 antagonist
    Patent number: 7364734
    Abstract: A method is provided for reducing the occurrence of fever, headache, nausea and/or vomiting associated with administration of a therapeutic compound to a mammal in need thereof, comprising administering to the mammal a first conditioning dose of a non-target cell depleting compound which binds to a cell surface receptor on a target mammalian cell; and administering a second therapeutic dose of the compound, wherein the second dose is higher than the first dose.
    Type: Grant
    Filed: March 10, 2005
    Date of Patent: April 29, 2008
    Assignee: Genentech, Inc.
    Inventors: Marvin R. Garovoy, Susan M. Kramer, Russell L. Dedrick, Karen Starko
  • Antibody formulation
    Patent number: 6991790
    Abstract: A stable aqueous pharmaceutical formulation comprising a therapeutically effective amount of antibody not subjected to prior lyophilization, a buffer maintaining the pH in the range from about 4.5 to about 6.0, a surfactant and a polyol is described, along with uses for such a formulation.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: January 31, 2006
    Assignee: Genentech, Inc.
    Inventors: Xanthe M. Lam, James Q. Oeswein, Boonsri Ongpipattanakul, Zehra Shahrokh, Sharon X. Wang, Robert P. Weissburg, Rita L. Wong
  • Anti-tumor antibody compositions and methods of use
    Patent number: 6824780
    Abstract: The invention provides antibodies targeted at a tumor antigen prevalent on prostate tumors and methods useful in alleviating cancers expressing the antigen, as well as nucleic acids and cells for expressing the antibodies.
    Type: Grant
    Filed: October 27, 2000
    Date of Patent: November 30, 2004
    Assignee: Genentech, Inc.
    Inventors: Brigitte Devaux, Gilbert-Andre Keller, Hartmut Koeppen, Lawrence A. Lasky
  • Protein recovery
    Patent number: 6716598
    Abstract: The invention herein provides a method for recovering a polypeptide comprising exposing a composition comprising a polypeptide to a reagent which binds to, or modifies, the polypeptide, wherein the reagent is immobilized on a solid phase; and then passing the composition through a filter bearing a charge which is opposite to the charge of the reagent in the composition, so as to remove leached reagent from the composition.
    Type: Grant
    Filed: August 27, 2001
    Date of Patent: April 6, 2004
    Assignee: Genentech, Inc.
    Inventors: Gregory S. Blank, Daljit S. Narindray, Gerardo A. Zapata
  • Protein recovery
    Patent number: 6322997
    Abstract: The invention herein provides a method for recovering a polypeptide comprising exposing a composition comprising a polypeptide to a reagent which binds to, or modifies, the polypeptide, wherein the reagent is immobilized on a solid phase; and then passing the composition through a filter bearing a charge which is opposite to the charge of the reagent in the composition, so as to remove leached reagent from the composition.
    Type: Grant
    Filed: December 14, 1999
    Date of Patent: November 27, 2001
    Assignee: Genentech, Inc.
    Inventors: Gregory S. Blank, Daljit S. Narindray, Gerardo A. Zapata
  • Antibody formulation
    Patent number: 6171586
    Abstract: A stable aqueous pharmaceutical formulation comprising a therapeutically effective amount of an antibody not subjected to prior lyophilization, a buffer maintaining the pH in the range from about 4.5 to about 6.0, a surfactant and a polyol is described, along with uses for such a formulation.
    Type: Grant
    Filed: June 12, 1998
    Date of Patent: January 9, 2001
    Assignee: Genentech, Inc.
    Inventors: Xanthe M. Lam, James Q. Oeswein, Boonsri Ongpipattanakul, Zahra Shahrokh, Sharon X. Wang, Robert P. Weissburg, Rita L. Wong