Patents Represented by Attorney, Agent or Law Firm Lee Tan
  • Method of treatment using humanized anti-CD11a antibodies
    Patent number: 6703018
    Abstract: Humanized anti-CD11a antibodies and various uses therefor are disclosed. The humanized anti-CD11a antibody may bind specifically to human CD11a I-domain, have an IC50(nM) value of no more than about 1 nM for preventing adhesion of Jurkat cells to normal human epidermal keratinocytes expressing ICAM-1, and/or an IC50 (nM) value of no more than about 1 nM in the mixed lymphocyte response assay.
    Type: Grant
    Filed: February 28, 2001
    Date of Patent: March 9, 2004
    Assignee: Genentech, Inc.
    Inventors: Paula M. Jardieu, Leonard G. Presta
  • Treatment of LFA-1 associated disorders with increasing doses of LFA-1 antagonist
    Patent number: 6652855
    Abstract: A method is provided for reducing the occurrence of fever, headache, nausea and/or vomiting associated with administration of a therapeutic compound to a mammal in need therof, comprising administering to the mammal a first conditioning dose of a non-target cell depleting compound which binds to a cell surface receptor on a target mammalian cell; and administering a second therapeutic dose of the compound, wherein the second dose is higher than the first dose.
    Type: Grant
    Filed: February 11, 2002
    Date of Patent: November 25, 2003
    Assignees: Genentech, Inc., XOMA Ltd.
    Inventors: Marvin R. Garovoy, Susan M. Kramer, Russell L. Dedrick, Karen Starko
  • Treatment method
    Patent number: 6582698
    Abstract: A method is provided for reducing the occurrence of fever, headache, nausea and/or vomiting associated with administration of a therapeutic compound to a mammal in need thereof, comprising administering to the mammal a first conditioning dose of a non-target cell depleting compound which binds to a cell surface receptor on a target mammalian cell; and administering a second therapeutic dose of the compound, wherein the second dose is higher than the first dose.
    Type: Grant
    Filed: March 28, 2001
    Date of Patent: June 24, 2003
    Assignees: Genentech, Inc., XOMA Technology, Ltd.
    Inventors: Russell L. Dedrick, Marvin R. Garovoy, Susan M. Kramer, Karen M. Starko