Patents Represented by Attorney, Agent or Law Firm LeeAnn Gorthey
  • Patent number: 7834138
    Abstract: Segmented water soluble polymers, containing a higher molecular weight segment linked to a lower molecular weight segment, are described. In one embodiment, the polymer segments are poly(ethylene glycol) segments. The segmented polymers are functionalized and are useful for conjugation to various moieties such as pharmacologically active substances. Also described are conjugates of such polymers and methods of their preparation.
    Type: Grant
    Filed: April 11, 2006
    Date of Patent: November 16, 2010
    Assignee: Nektar Therapeutics
    Inventors: Antoni Kozlowski, Xiaoming Shen, Michael D. Bentley, Zhihao Fang, Tony L. Sander
  • Patent number: 7417069
    Abstract: Compounds having the structure I: are useful for inducing cell death (apoptosis) and in immunosuppression. In structure I, CR1R2 is selected from CHOH, C?O, CHF, CF2 and C(CF3)OH; CR6 and CR13 are selected from CH, COH and CF; CR7R8, CR9R10 and CR11R12 are selected from CH2, CHOH, C?O, CHF and CF2; and CR3R4R5 is selected from CH3, CH2OH, C?O, COOH, CH2F, CHF2 and CF3; such that: at least one of R1-R13 comprises fluorine; no more than two of CR3R4R5, CR6, CR7R8, CR9R10, CR11R12, and CR13 comprises fluorine or oxygen; and, when CR1R2 is CHOH, CR3R4R5 is not CH2F.
    Type: Grant
    Filed: August 23, 2005
    Date of Patent: August 26, 2008
    Assignee: Pharmagenesis, Inc.
    Inventors: Dongcheng Dai, John H. Musser
  • Patent number: 7005521
    Abstract: Complexes of a selected class of chiral ligands with molybdenum, tungsten or chromium, preferably molybdenum, are effective as catalysts in highly enantioselective and regioselective alkylation of allylic substrates. Such compositions provide a versatile and low-cost alternative to existing catalysts.
    Type: Grant
    Filed: February 7, 2000
    Date of Patent: February 28, 2006
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Barry M. Trost, Iwao Hachiya
  • Patent number: 6846921
    Abstract: Chimeric oligonucleotide of the formula 5?-W—X1—Y—X2—Z-3?, where W represents a 5?-O-alkyl nucleotide, each of X1 and X2 represents a block of seven to twelve phosphodiester-linked 2?-O-alkyl ribonucleotides, Y represents a block of five to twelve phosphorothioate-linked deoxyribonucleotides, and Z represents a blocking group effective to block nuclease activity at the 3? end of the oligonucleotide, are described. These compounds exhibit high resistance to endo- and exonucleases, high sequence specificity, and the ability to activate RNAse H, as evidenced by efficient and long-lasting suppression of target mRNA. The oligonucleotides are preferably transfected into cells in formulations containing a lipid-peptoid conjugate carrier molecule of the formula L-linker-[N(CH2CH2NH2)CH2(C?O)—N(CH2CH2R)CH2(C?O)—N(CH2CH2R)CH2(C?O)]3—NH2, where L is a lipid moiety, including a steroid, and each group R is independently selected from alkyl, aminoalkyl, and aralkyl.
    Type: Grant
    Filed: April 3, 2001
    Date of Patent: January 25, 2005
    Assignee: Chiron Corporation
    Inventors: Michael A. Innis, Christoph J. Reinhard, Ronald N. Zuckermann
  • Patent number: 6825313
    Abstract: Disclosed are copolymers based on aspartic acid or its precursor molecules and methods of their production. The copolymers are water-soluble over a wide range of composition and molecular weight. Their preparation involves conversion of a polysuccinimide to copolymers of defined composition, containing aspartate and succinimide residues and/or residues of asparagine. In particular, the copolymers include water-soluble terpolymers of aspartate, asparagine, and succinimide.
    Type: Grant
    Filed: May 7, 2003
    Date of Patent: November 30, 2004
    Assignee: Aquero Company
    Inventor: C. Steven Sikes
  • Patent number: 6818113
    Abstract: A method and device for injecting a liquid sample into an electrolyte channel in a microfluidics device is disclosed. The device has a channel network that includes an electrolyte channel having upstream and downstream channel portions and first, second, and third side channels that intersect the electrolyte channel between the two channel portions at first, second, and third ports, respectively. In the method, a sample is moved electrokinetically into the electrolyte channel, to form a defined sample volume therein. By simultaneously controlling the voltage applied to the three side channels, and at least one of the upstream and downstream channel end portions, the sample volume element can be shaped to have a desired leading- and trailing-edge shape and/or distribution of sample components within the volume elements.
    Type: Grant
    Filed: February 10, 2001
    Date of Patent: November 16, 2004
    Assignee: Aclara Biosciences, Inc.
    Inventors: Stephen J. Williams, Hong Dong Tan, Hung Pin Kao, Wyatt N. Vreeland
  • Patent number: 6784291
    Abstract: Antisense compositions targeted against an mRNA sequence coding for a selected protein, at a region having its 5′ end from 1 to about 25 base pairs downstream of a normal splice acceptor junction in the preprocessed mRNA, are disclosed. The antisense compound is RNase-inactive, and is preferably a phosphorodiamidate-linked morpholino oligonucleotide. Such targeting is effective to inhibit natural mRNA splice processing, produce splice variant mRNAs, and inhibit normal expression of the protein.
    Type: Grant
    Filed: May 4, 2001
    Date of Patent: August 31, 2004
    Assignee: AVI BioPharma, Inc.
    Inventors: Patrick L. Iversen, Robert Hudziak
  • Patent number: 6747152
    Abstract: Complexes of a selected class of chiral ligands with molybdenum, tungsten or chromium, preferably molybdenum, are effective as catalysts in highly enantioselective and regioselective alkylation of allylic substrates.
    Type: Grant
    Filed: February 5, 2003
    Date of Patent: June 8, 2004
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Barry M. Trost, Iwao Hachiya
  • Patent number: 6685813
    Abstract: A method of separating components having a given negative or positive charge and contained in a sample is disclosed. The method involves, in one embodiment, loading a microchannel with a sample, placed between a trailing-edge electrolyte having a selected concentration of a titratable species, and a leading-edge electrolyte.
    Type: Grant
    Filed: August 20, 2001
    Date of Patent: February 3, 2004
    Assignee: Aclara Biosciences, Inc.
    Inventors: Stephen J. Williams, Hong Dong Tan, Hung Pin Kao, Wyatt N. Vreeland
  • Patent number: 6686338
    Abstract: A method is described for improving the pharmacokinetics of a drug in a subject, by co-administering oligomers, preferably PMO's (phosphorodiamidate morpholino oligonucleotides), antisense to RNAs encoding drug-metabolizing enzymes, particularly p450 enzymes. The oligomers reduce production of the drug-metabolizing enzymes, which extends drug half-life and effectiveness and/or decreases drug toxicity.
    Type: Grant
    Filed: May 17, 2000
    Date of Patent: February 3, 2004
    Assignee: The Board of Regents of the University of Nebraska
    Inventor: Patrick L. Iversen
  • Patent number: 6677445
    Abstract: Chimeric oligonucleotide of the formula 5′-W-X1-Y-X2-Z-3′, where W represents a 5′-O-alkyl nucleotide, each of X1 and X2 represents a block of seven to twelve phosphodiester-linked 2′-O-alkyl ribonucleotides, Y represents a block of five to twelve phosphorothioate-linked deoxyribonucleotides, and Z represents a blocking group effective to block nuclease activity at the 3′ end of the oligonucleotide, are described. These compounds exhibit high resistance to endo- and exonucleases, high sequence specificity, and the ability to activate RNAse H, as evidenced by efficient and long-lasting suppression of target mRNA.
    Type: Grant
    Filed: August 25, 2000
    Date of Patent: January 13, 2004
    Assignee: Chiron Corporation
    Inventors: Michael A. Innis, Christoph J. Reinhard, Ronald N. Zuckermann
  • Patent number: 6677153
    Abstract: The invention relates to compositions comprising oligomers antisense to bacterial 16S or 23S rRNA and capable of selectively modulating the biological activity thereof, and methods for their use. More particularly, the invention relates to antisense oligomers directed to 16S or 23S rRNA found in one or more particular bacteria, or generally conserved among bacteria in general, and to pharmaceutical compositions and methods of treatment comprising the same.
    Type: Grant
    Filed: November 29, 2000
    Date of Patent: January 13, 2004
    Assignee: AVI BioPharma, Inc.
    Inventor: Patrick L. Iversen
  • Patent number: 6653460
    Abstract: A novel class of peptides selectively block class E voltage-gated calcium channels. The class is exemplified by HG peptides such as HG-1, which is isolated from the venom-producing cells of the tarantula Hysterocrates gigas. Also disclosed are methods of producing blocking class E channels using the peptides. HG peptides have utility, for example, in inhibiting oxytocin release and for use as anticonvulsants.
    Type: Grant
    Filed: August 16, 2000
    Date of Patent: November 25, 2003
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Robert Newcomb, Andrew L. Palma, Balazs G. Szoke, Katalin Tarczy-Hornoch, William F. Hopkins, Ruth L. Cong, George P. Miljanich, Robin Dean, Laszlo Nadasdi, Laszlo Urge, Stephen Scott Bowersox
  • Patent number: 6654505
    Abstract: An apparatus and system are provided for simultaneously analyzing a plurality of analytes anchored to microparticles. Microparticles each having a uniform population of a single kind of analyte attached are disposed as a substantially immobilized planar array inside a flow chamber where steps of an analytical process are carried out by delivering a sequence of processing reagents to the microparticles by a fluidic system under microprocessor control. In response to such process steps, an optical signal is generated at the surface of each microparticle which is characteristic of the interaction between the analyte carried by the microparticle and the delivered processing reagent. The plurality of analytes are simultaneously analyzed by collecting and recording images of the optical signals generated by all the microparticles in the planar array. A key feature of the invention is the correlation of the sequence of optical signals generated by each microparticle in the planar array during the analytical process.
    Type: Grant
    Filed: July 17, 2001
    Date of Patent: November 25, 2003
    Assignee: Lynx Therapeutics, Inc.
    Inventors: John Bridgham, Kevin Corcoran, George Golda, Michael C. Pallas, Sydney Brenner
  • Patent number: 6620843
    Abstract: Water soluble triptolide prodrugs are used as anticancer agents, and are found to be more effective in vivo, at lower doses, in reducing tumor size than the widely used chemotherapeutic agents 5-fluorouracil and irinotecan.
    Type: Grant
    Filed: January 19, 2001
    Date of Patent: September 16, 2003
    Assignee: Pharmagenesis
    Inventors: John M. Fidler, Ke Li
  • Patent number: 6610827
    Abstract: The present invention provides novel potassium channel subunits (denoted Kv-SL1 and Kv-SL2, and collectively as Kv-SL) and polynucleotides which identify and encode them. The invention also provides expression vectors and host cells comprising nucleic acid sequence encoding Kv-SL. The invention also provides antibodies of Kv-SL and methods of diagnosing and treating diseases associated with expression of Kv-SL, and screening assays employing the protein, nucleotide, and antibody compositions.
    Type: Grant
    Filed: October 28, 1998
    Date of Patent: August 26, 2003
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: John R. Forsayeth, Byron Zhao, Raymond A. Chavez
  • Patent number: 6572881
    Abstract: In accordance with the present invention, there are provided lipid-conjugated polyamide compounds and related compositions and methods thereof. Lipid-conjugated polyamide compounds of the present invention are particularly useful as vehicles for delivering biologically active agents to a target site. In particular, the invention compounds are effective at facilitating the delivery of polynucleotides to cells. The present invention also provides a method for producing stable formulations of polynucleotides complexed with a delivery vehicle.
    Type: Grant
    Filed: July 21, 2000
    Date of Patent: June 3, 2003
    Assignee: Chiron Corporation
    Inventors: Ronald N. Zuckermann, Chin-Yi Huang, John E. Murphy, Tetsuo Uno
  • Patent number: 6569893
    Abstract: Compounds which are prodrugs of triptolide or its derivatives, containing an amino acid or oligopeptide moiety, are used for anticancer or immunosuppressive treatment.
    Type: Grant
    Filed: March 14, 2002
    Date of Patent: May 27, 2003
    Assignee: Pharmagenesis, Inc.
    Inventors: Dongcheng Dai, John M. Fidler, John H. Musser
  • Patent number: 6569450
    Abstract: In accordance with the present invention, there are provided lipid-conjugated polyamide compounds and related compositions and methods thereof. Lipid-conjugated polyamide compounds of the present invention are particularly useful as vehicles for delivering biologically active agents to a target site. In particular, the invention compounds are effective at facilitating the delivery of polynucleotides to cells. The present invention also provides a method for producing stable formulations of polynucleotides complexed with a delivery vehicle.
    Type: Grant
    Filed: July 21, 2000
    Date of Patent: May 27, 2003
    Assignee: Chiron Corporation
    Inventors: Ronald N. Zuckermann, Chin-Yi Huang, John E. Murphy, Tetsuo Uno
  • Patent number: 6548537
    Abstract: Compounds useful in immunosuppressive, anti-inflammatory and anticancer treatment are described. The compounds are triptolide analogs with improved water solubility and generally lower toxicity than the parent compound.
    Type: Grant
    Filed: March 2, 2001
    Date of Patent: April 15, 2003
    Assignee: Pharmagenesis, Inc.
    Inventors: Dongcheng Dai, Hongwei Yuan, John H. Musser