Patents Represented by Attorney Leigh Firestone

Find this attorney in the Justia Lawyer Directory

  • Solid-phase synthesis of N-alkyl amides
    Patent number: 5861532
    Abstract: Methods for solid phase synthesis of N-alkyl amides comprise reductive amination of carbonyl compounds using a reducing agent and an amine-containing linker bound to a solid support. The methods afford high yields of linker-bound, monoalkylated amines, and subsequent coupling with acid derivatives provide derivatized N-substituted amides in excellent yields after cleavage from the solid-phase. Compositions useful in solid phase synthesis are also described.
    Type: Grant
    Filed: March 4, 1997
    Date of Patent: January 19, 1999
    Assignee: Chiron Corporation
    Inventors: Edward G. Brown, John M. Nuss