Patents Represented by Attorney Leigh P. Gregory
  • Patent number: 7842749
    Abstract: This invention deals with a tissue protecting, spray-on film composition comprising an amphiphilic film-forming, segmented/block copolymer derived form at least one water-soluble monomer and at least another water-insoluble monomer, wherein the film can be formed from a water soluble organic solvent such as 2-propanol, acetone, and ethyl acetate. The film can contain a bioactive agent including those to have antimicrobial, anesthetic, anti-inflammatory, and wound-healing activities.
    Type: Grant
    Filed: July 5, 2005
    Date of Patent: November 30, 2010
    Assignee: Poly-Med, Inc.
    Inventors: Shalaby W. Shalaby, James M. Lindsey, III
  • Patent number: 7820289
    Abstract: Composite fibrous constructs are made of combinations of inorganic-organic hybrid monofilament or multifilament yarns containing at least 6 weight percent of inorganic micro-/nanoparticles and organic monofilament or multifilament yarn with typical examples of the hybrid yarn matrix made of absorbable or non-absorbable thermoplastic polymers and final constructs being in the form of knitted or woven meshes and braided ligatures intended to perform under specific mechanically, biologically, and/or radiologically related functions.
    Type: Grant
    Filed: June 23, 2009
    Date of Patent: October 26, 2010
    Assignee: Poly-Med, Inc.
    Inventors: Shalaby W Shalaby, Kimberly A Carpenter, Kenneth W Clinkscales
  • Patent number: 7771651
    Abstract: This invention deals with package components for radiochemical sterilization of medical or pharmaceutical products consisting of a hermetically sealed foil pack containing (1) a solid device, as in absorbable sutures and meshes, in a perforated holder or a liquid formulation in a sealed, flexible dispenser, as in absorbable cyanoacrylate-based tissue adhesive; (2) a microparticulate, unstabilized polyformaldehyde as a source of radiolytically generated formaldehyde encased in a sealed pouch comprising a porous, non-woven or woven fabric; and (3) a nitrogenous compound capable of reacting with residual formaldehyde, such as melamine or urea, that is encased in a sealed pouch comprising a porous, non-woven or woven fabric.
    Type: Grant
    Filed: February 18, 2010
    Date of Patent: August 10, 2010
    Assignee: Poly-Med, Inc.
    Inventor: Shalaby W Shalaby
  • Patent number: 7731795
    Abstract: Single, acentric, rhombohedral, fluoroberyllium borate crystals of a size sufficient for use in a variety of laser and non-optical applications are formed by a hydrothermal method.
    Type: Grant
    Filed: December 4, 2006
    Date of Patent: June 8, 2010
    Assignee: Clemson University
    Inventors: Joseph W Kolis, Colin D. McMillen
  • Patent number: 7722914
    Abstract: Pharmacologically active, easy-to-deploy, biomechanically compatible, inflatable endovascular, drug-eluting stent are formed of a primary expandable polymeric or metallic construct, intimately mantled with a biomechanically compatible, polymeric microporous, microfibrous, compliant, stretchable fabric formed by direct electrospinning onto the outside surface of the primary construct using at least one polymer solution containing at least one active compound, selected from those expected to control key biological events leading to in-stent restenosis.
    Type: Grant
    Filed: May 14, 2008
    Date of Patent: May 25, 2010
    Assignee: Poly-Med, Inc
    Inventor: Shalaby W. Shalaby
  • Patent number: 7709556
    Abstract: Absorbable radiation or radiochemically sterilized medical devices, including sutures, whose breaking strength and absorption profile can be modulated by controlling the total dose received during sterilization are disclosed.
    Type: Grant
    Filed: October 9, 2003
    Date of Patent: May 4, 2010
    Assignee: Poly-Med, Inc.
    Inventor: Shalaby W. Shalaby
  • Patent number: 7694813
    Abstract: This invention deals with package components for radiochemical sterilization of medical or pharmaceutical products consisting of a hermetically sealed foil pack containing (1) a solid device, as in absorbable sutures and meshes, in a perforated holder or a liquid formulation in a sealed, flexible dispenser, as in absorbable cyanoacrylate-based tissue adhesive; (2) a microparticulate, unstabilized polyformaldehyde as a source of radiolytically generated formaldehyde encased in a sealed pouch comprising a porous, non-woven or woven fabric; and (3) a nitrogenous compound capable of reacting with residual formaldehyde, such as melamine or urea, that is encased in a sealed pouch comprising a porous, non-woven or woven fabric.
    Type: Grant
    Filed: September 16, 2005
    Date of Patent: April 13, 2010
    Assignee: Poly-Med, Inc.
    Inventor: Shalaby W. Shalaby
  • Patent number: 7694815
    Abstract: Package components for the radiochemical sterilization of medical devices contain paraformaldehyde as the precursor of the radiolytically generated, sterilizing dose of formaldehyde, premixed with a particulate solid dispersant of, preferably, polyethylene or silica gel, which facilitates the free passage of the formaldehyde to the package gaseous environment or additionally, absorbs trace amounts of moisture in the package, thus, facilitating the device manufacturing process and increasing shelf-stability.
    Type: Grant
    Filed: June 11, 2008
    Date of Patent: April 13, 2010
    Assignee: Poly-Med, Inc.
    Inventor: Shalaby W Shalaby
  • Patent number: 7632765
    Abstract: Composite fibrous constructs are made of combinations of inorganic-organic hybrid monofilament or multifilament yarns containing at least 6 weight percent of inorganic micro-/nanoparticles and organic monofilament or multifilament yarn with typical examples of the hybrid yarn matrix made of absorbable or non-absorbable thermoplastic polymers and final constructs being in the form of knitted or woven meshes and braided ligatures intended to perform under specific mechanically, biologically, and/or radiologically related functions.
    Type: Grant
    Filed: July 25, 2007
    Date of Patent: December 15, 2009
    Assignee: Poly - Med, Inc.
    Inventors: Shalaby W Shalaby, Kenneth W Clinkscales, Kimberly A. Carpenter
  • Patent number: 7591896
    Abstract: Single, acentric, hexagonal, beryllium borate crystals having the formula Sr2Be2B2O7 and of a size sufficient for use in a variety of laser and non-optical applications are formed by a hydrothermal method. Alternate structures are formed by partially substituting the strontium ion with at least one other divalent metal ion.
    Type: Grant
    Filed: December 4, 2006
    Date of Patent: September 22, 2009
    Assignee: Clemson University
    Inventors: Joseph W Kolis, Colin D. McMillen, Henry G. Giesber, III
  • Patent number: 7582231
    Abstract: The present invention is directed to a composite having tunable radiation diffracting properties which includes a flexible, water-free polymeric matrix and a crystalline colloidal array of particles having a lattice spacing, the array being embedded in the polymeric matrix and the lattice spacing changing responsive to stress applied to the polymeric matrix, thereby causing the radiation diffracting properties to change, wherein the polymeric matrix, the lattice spacing and the radiation diffracting properties all return to their original state essentially immediately upon removal of the stress. The present inventive composite is preferably made by a process, which involves forming a preliminary hydrogel polymerized crystalline colloidal array (PCCA), dehydrating the PCCA, and then forming a final, encapsulating polymeric matrix.
    Type: Grant
    Filed: September 16, 2005
    Date of Patent: September 1, 2009
    Inventors: Stephen H. Foulger, Ping Jiang
  • Patent number: 7563320
    Abstract: Scandium, yttrium, and lanthanide sesquioxide crystals having the formula Ln2O3, wherein Ln is selected from Sc, Y, La, Ce, Pr, Nd, Pm, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, and Lu, with or without an activator ion, are made by a hydrothermal method for a variety of end-use applications.
    Type: Grant
    Filed: December 18, 2007
    Date of Patent: July 21, 2009
    Inventors: Joseph Kolis, Colin D. McMillen
  • Patent number: 7540917
    Abstract: Single, acentric, rhombohedral, potassium fluoroberyllium borate crystals of a size sufficient for use in a variety of laser and non-optical applications are formed by a hydrothermal method.
    Type: Grant
    Filed: December 4, 2006
    Date of Patent: June 2, 2009
    Assignee: Clemson University
    Inventors: Joseph W Kolis, Colin D. McMillen, Henry G. Giesber, III
  • Patent number: 7494703
    Abstract: A thermally printable commercially functional cash register tape produced from a thin machine direction oriented, heat stabilized, multi-layer, coextruded thermoplastic film is described. This thermoplastic tape replaces the currently used paper cash register tape. It will accept printing, has sufficient machine direction stiffness and sufficiently reduced surface electrical charges to function in conventional commercial cash register printers. The thermoplastic tape is much thinner than the conventional paper tape so a roll of the plastic register tape contains about 4.7 times the paper length of a typical cash register roll.
    Type: Grant
    Filed: December 4, 2003
    Date of Patent: February 24, 2009
    Inventor: Tom Hopkins
  • Patent number: 7468658
    Abstract: A system to monitor the entry and exit of individuals from a facility and to identify individuals who have entered the facility and not indicated safe departure from the facility by reporting to an emergency reporting area and activating the system with an identification card. The system also indicates the most likely area of a facility in which an individual may be found. Such census information is made available to emergency workers and is of significant value in rescue efforts following facility evacuations. A modification of the systems allows an attendant to monitor the entry, exit, and re-entry of individuals traveling in two or more vehicles following stops.
    Type: Grant
    Filed: November 21, 2003
    Date of Patent: December 23, 2008
    Inventor: Don L. Bouressa
  • Patent number: 7465489
    Abstract: This invention deals with a family of inorganic-organic hybrid, melt-extruded filaments having variable cross-sectional geometry with a cross-sectional area ranging between 100 ?2 and 4 mm2, wherein the inorganic component comprises at least 10 weight percent of the total system and is present as dispersed micro-/nanoparticles in an organic absorbable or non-absorbable matrix representing no more than 90 weight percent. Hybrid filaments are particularly useful for the production of absorbable/disintegratable coil components of an absorbable/disintegratable endoureteral stent and radiopaque surgical markers or sutures.
    Type: Grant
    Filed: November 15, 2006
    Date of Patent: December 16, 2008
    Assignee: Poly-Med, Inc.
    Inventors: Shalaby W Shalaby, Kenneth W Clinkscales, Kimberly A. Carpenter
  • Patent number: 7435789
    Abstract: The present invention is directed toward an absorbable crystalline segmented copolymer comprising a polyalkylene succinate segment end-grafted in a single-step with a mixture of monomers comprising caprolactone, l-lactide, and/or glycolide. The present invention is also directed toward an absorbable crystalline segmented copolymer arising from a trihydroxy compound that is reacted in a single-step with a mixture of monomer comprising ?-caprolactone, l-lactide, and/or glycolide to produce monocentric polyaxial polymers.
    Type: Grant
    Filed: January 29, 2004
    Date of Patent: October 14, 2008
    Assignee: Poly-Med, Inc.
    Inventor: Shalaby W Shalaby
  • Patent number: 7416559
    Abstract: Pharmacologically active, easy-to-deploy, biomechanically compatible, inflatable endovascular, drug-eluting stent are formed of a primary expandable polymeric or metallic construct, intimately mantled with a biomechanically compatible, polymeric microporous, microfibrous, compliant, stretchable fabric formed by direct electrospinning onto the outside surface of the primary construct using at least one polymer solution containing at least one active compound, selected from those expected to control key biological events leading to in-stent restenosis.
    Type: Grant
    Filed: March 27, 2006
    Date of Patent: August 26, 2008
    Assignee: Poly-Med, Inc.
    Inventor: Shalaby W. Shalaby
  • Patent number: 7381664
    Abstract: Organic inherently conductive polymers, such as those based on polyaniline, polypyrrole and polythiophene, are formed in situ onto polymeric surfaces that are chemically activated to bond, ionically, the conductive polymers to the substrates. The polymeric substrate is preferably a preshaped or preformed thermoplastic film, fabric, tube, or a medical device for tissue repair regeneration and/or replacement, although other forms of thermoplastic and thermoset polymers can be used as the substrates for pretreatment using, most preferably, C-succinylation-based processes followed by exposure to an oxidatively polymerizable compound capable of forming an electrically conductive polymer. The resultant conductive surface imparts unique properties to the substrates and allows their use in antistatic clothing, surface conducting films for electronic components and the like, and electromagnetic interference shielding for civilian and military installations as well as implantable medical devices.
    Type: Grant
    Filed: March 17, 2006
    Date of Patent: June 3, 2008
    Assignee: Poly-Med Inc.
    Inventor: Shalaby W Shalaby
  • Patent number: 7377684
    Abstract: A blending system incorporating a blender with an operating cavity housing a plurality of elongate rod elements extending at least partially along the length of the operating cavity such that controlled relative movement between the rod elements and a multi-constituent composition within the operating cavity causes the development of predefined structures within the multi-constituent composition. The cavity within the blender incorporates a diminished cross-section in the vicinity of its terminal end. Methods to provide controlled development of microstructures and properties are also provided.
    Type: Grant
    Filed: May 26, 2005
    Date of Patent: May 27, 2008
    Assignee: Clemson University
    Inventor: David A. Zumbrunnen