Patents Represented by Attorney Leigh P. Gregory
  • Patent number: 7842749
    Abstract: This invention deals with a tissue protecting, spray-on film composition comprising an amphiphilic film-forming, segmented/block copolymer derived form at least one water-soluble monomer and at least another water-insoluble monomer, wherein the film can be formed from a water soluble organic solvent such as 2-propanol, acetone, and ethyl acetate. The film can contain a bioactive agent including those to have antimicrobial, anesthetic, anti-inflammatory, and wound-healing activities.
    Type: Grant
    Filed: July 5, 2005
    Date of Patent: November 30, 2010
    Assignee: Poly-Med, Inc.
    Inventors: Shalaby W. Shalaby, James M. Lindsey, III
  • Patent number: 7820289
    Abstract: Composite fibrous constructs are made of combinations of inorganic-organic hybrid monofilament or multifilament yarns containing at least 6 weight percent of inorganic micro-/nanoparticles and organic monofilament or multifilament yarn with typical examples of the hybrid yarn matrix made of absorbable or non-absorbable thermoplastic polymers and final constructs being in the form of knitted or woven meshes and braided ligatures intended to perform under specific mechanically, biologically, and/or radiologically related functions.
    Type: Grant
    Filed: June 23, 2009
    Date of Patent: October 26, 2010
    Assignee: Poly-Med, Inc.
    Inventors: Shalaby W Shalaby, Kimberly A Carpenter, Kenneth W Clinkscales
  • Patent number: 7268098
    Abstract: A thermally printable commercially functional cash register tape produced from a thin oriented, heat stabilized, thermoplastic film is described. This thermoplastic tape replaces the currently used paper cash register tape. It will accept printing, has sufficient machine direction stiffness and sufficiently reduced surface electrical charges to function in conventional commercial cash register printers. The thermoplastic tape is much thinner than the conventional paper tape so a roll of the plastic register tape contains about 4.7 times the paper length of a typical cash register roll.
    Type: Grant
    Filed: November 28, 2005
    Date of Patent: September 11, 2007
    Inventor: Thomas E. Hopkins
  • Patent number: 7153452
    Abstract: A modified, mesophase pitch-based carbon fiber is disclosed which includes carbon nanotube reinforcements in an amount ranging from about 0.01 percent to about 1.0 percent by weight. Although the reinforcements actually decrease the excellent tensile modulus of the unmodified fiber, they provide a random microstructure, which can decrease brittle failure of the fiber caused by propagation of a flaw.
    Type: Grant
    Filed: September 12, 2003
    Date of Patent: December 26, 2006
    Assignee: Clemson University
    Inventors: Amod A. Ogale, Dan D Edie, Apparao M. Rao
  • Patent number: 7138464
    Abstract: Absorbable heterochain polymers carrying acid or basic groups, capable of ionic conjugation with basic or acidic bioactive agents, respectively, are produced by free-radical addition of unsaturated functional monomers onto absorbable liquid polymers and subsequent generation of reactive functionality or by direct copolymerization of a carboxylic initiator with cyclic monomers to produce liquid carboxyl-bearing copolyesters or polyester carbonates.
    Type: Grant
    Filed: October 24, 2003
    Date of Patent: November 21, 2006
    Assignee: Poly Med, Inc
    Inventor: Shalaby W. Shalaby
  • Patent number: 7048753
    Abstract: The present invention is directed to crystalline copolymers of l-lactide and a minor portion of a cyclic monomer, preferably ?-caprolactone or trimethylene carbonate or both. The present copolymers have a melting temperature of at least 150° C. and a crystallinity of at least 20%. Preferred are high molecular weight copolymers having an inherent viscosity of at least 1.1 dl/g. A variety of surgical constructs may be formed from the present copolymers. Disclosed are coated surgical constructs including sutures made of multifilament yarns of the present copolymers and coated with nitrogenous copolyesters which will bioabsorb in less than three years and will maintain at least 50% of their initial strength three weeks post-operatively.
    Type: Grant
    Filed: March 1, 2002
    Date of Patent: May 23, 2006
    Assignee: Poly-Med, Inc.
    Inventor: Shalaby W. Shalaby
  • Patent number: 6947208
    Abstract: An amplifying optical element for use within an optical fiber communication system is disclosed which includes a doped optical fiber, an optical excitation source which is physically integrated with and immediately adjacent to and surrounding doped optical fiber, the excitation source being capable of emitting sufficient light to enable power gain of the signal being transmitted, and an external power source electrically connected to the optical excitation source for initiating and maintaining the light emission. Preferably, the excitation source is a multilayer electrically conductive structure which includes a first layer immediately adjacent to the doped optical fiber, wherein the first layer is a transparent, electrically conductive material, a second layer adjacent to the first layer, wherein the second layer is an electroluminescing material, and a third layer adjacent to the second layer, wherein the third layer is an electrically conductive material.
    Type: Grant
    Filed: January 24, 2003
    Date of Patent: September 20, 2005
    Inventors: John Ballato, David L. Carroll
  • Patent number: 6794485
    Abstract: An absorbable crystalline, monocentric polyaxial copolymer comprising a central carbon or nitrogen atom and at least three axes, each of which includes an amorphous flexible component adjacent and originating from the central atom and a rigid, crystallizable component extending outwardly from the amorphous, flexible component is disclosed along with the use of such copolymer in medical devices which may contain a bioactive agent. The present invention also relates to a suture, stents, stent mantles and sealing devices made from the polyaxial copolymer.
    Type: Grant
    Filed: October 31, 2002
    Date of Patent: September 21, 2004
    Assignee: Poly-Med, Inc.
    Inventors: Shalaby W. Shalaby, Torbjorn Mathisen
  • Patent number: 6780799
    Abstract: The present invention is directed to surface functionalized fabrics, particularly those based on non-woven polypropylene, wherein the functional groups are capable of binding antimicrobial agents through ionic conjugation to control their release and prolong their antimicrobial activity. The invention also deals with Nylon 6 fabric that is complexed with iodine to control its release and to achieve prolonged antimicrobial activities. Similarly, polypropylene and cellulosic fabrics grafted with N-vinylpyrrolidone are disclosed. The N-vinylpyrrolidone can also complex with iodine to control its release and provide antimicrobial activity over desired periods of time.
    Type: Grant
    Filed: June 3, 2003
    Date of Patent: August 24, 2004
    Assignee: Poly-Med, Inc.
    Inventor: Shalaby W. Shalaby
  • Patent number: 6775588
    Abstract: A system by which a portable computer on a cart translates warehouse locations to light addresses of locations on storage bays in a storage facility and communicates instructions by means of a bi-directional, dual transmitter/receiver element on the cart to a pick-controller unit positioned on each bay. The pick-controller unit on the bay is connected with intelligent light assemblies at each location on the bay that, in response to instructions from the portable computer, illuminate indicating the need for, and quantity of a SKU to be retrieved from the illuminated location. In addition, the portable computer communicates instructions using the bi-directional, dual transmitter/receiver element to the put-controller unit positioned on the cart that in turn communicates these instructions to intelligent light assemblies adjacent to specific receptacles located on the cart.
    Type: Grant
    Filed: July 10, 2003
    Date of Patent: August 10, 2004
    Assignee: Foxfire Technologies, Inc.
    Inventor: John C. Peck
  • Patent number: 6723114
    Abstract: The present invention is directed to bioabsorbable adhesive/hemostatic formulations of a 2-alkoxyalkylcyanoacrylate and liquid or solid polymeric modifiers and adjuvant. The present adhesive formulations are useful as tissue adhesive/sealants, hemostatic agents, and as a means for patching or anastomic coupling of damaged organs.
    Type: Grant
    Filed: August 17, 2001
    Date of Patent: April 20, 2004
    Assignee: Poly-Med, Inc.
    Inventor: Shalaby W. Shalaby
  • Patent number: 6699940
    Abstract: The present invention is directed toward cyanoacrylate-based tissue adhesive or sealant compositions comprising cyanoacrylate-capped heterochain polymers, such as those comprising one or more oxyalkylene, alkylene carbonate, and ester-units derived from cyclic lactones. Such compositions can be radiochemically sterilized and used in repairing internal organs or tissue blocking body conduits.
    Type: Grant
    Filed: November 20, 2002
    Date of Patent: March 2, 2004
    Assignee: Poly Med, Inc.
    Inventor: Shalaby W. Shalaby
  • Patent number: 6596657
    Abstract: The present invention is directed to surface functionalized fabrics, particularly those based on non-woven polypropylene, wherein the functional groups are capable of binding antimicrobial agents through ionic conjugation to control their release and prolong their antimicrobial activity. The invention also deals with Nylon 6 fabric that is complexed with iodine to control its release and to achieve prolonged antimicrobial activities. Similarly, polypropylene and cellulosic fabrics grafted with N-vinylpyrrolidone are disclosed. The N-vinylpyrrolidone can also complex with iodine to control its release and provide antimicrobial activity over desired periods of time.
    Type: Grant
    Filed: February 17, 2000
    Date of Patent: July 22, 2003
    Assignee: Poly-Med, Inc.
    Inventor: Shalaby W. Shalaby
  • Patent number: 6569797
    Abstract: An improved method for preparing low density ceramics is described wherein the process incorporates paper residuals which are a by-product of the paper recycling process. The method for making a low density-ceramic comprises the steps of: a) providing a paper residual comprising from about 0.5 to about 99 percent, by weight, of at least one filler, from about 0 to about 20 percent, by weight, of a dye, from about 0 to about 10 percent, by weight, of an ink, from about 0.5 to about 99.5 percent, by weight, of paper fiber, and from about 0 to about 30 percent, by weight, of other components, based on a dry weight of the residual; b) admixing a ceramic material with the paper residual, the ceramic material comprising up to about 90%, by weight, of the admixture, based on a dry weight of the admixture; c) forming the admixture into a desired shape; and d) firing the admixture to a temperature ranging from about 1850° F. to about 2900° F.
    Type: Grant
    Filed: November 17, 2000
    Date of Patent: May 27, 2003
    Assignee: Clemson University
    Inventor: Denis A. Brosnan
  • Patent number: 6551580
    Abstract: A variety of phosphonylated heterochain polymers are disclosed, including, most preferably, phosphonylated polymethyl methacrylate. For each polymeric composition the phosphorous atom of a phosphorous-containing functional group is covalently bonded to a carbon atom of the polymeric chain. The phosphorous atoms are present in an amount of at least about 0.1 percent by weight in each polymeric composition.
    Type: Grant
    Filed: May 22, 2002
    Date of Patent: April 22, 2003
    Inventor: Shalaby W. Shalaby
  • Patent number: 6551610
    Abstract: This invention deals with an absorbable, gel-forming composition for multifaceted prevention of post-operative surgical adhesion through a plurality of physico-pharmacological modes, comprising a solution of one or more bioactive compounds in a liquid copolymeric vehicle made by end-grafting one or more cyclic monomer onto a polyalkylene glycol. More specifically, the bioactive drugs can display one or more pharmacological activity associated with antiangiogenic, antineoplastic, anti-inflammatory, and anti-proliferative effects.
    Type: Grant
    Filed: April 24, 2002
    Date of Patent: April 22, 2003
    Assignee: Poly-Med, Inc.
    Inventors: Shalaby W. Shalaby, Waleed S. W. Shalaby, Marc Shalaby
  • Patent number: 6503991
    Abstract: The present invention is directed to crystalline, absorbable block/segmented copolymers which are the reaction product of a linear prepolymer which is a polytrimethylene dicarboxylate of succinic, glutaric, or adipic acid and either glycolide, 1-lactide, or mixtures thereof. Preferably the prepolymer is preliminarily end-grafted with a further monomer such as trimethylene carbonate or &egr;-caprolactone. The crystalline copolymers of this invention are tailored for fabrication into several forms of absorbable biomedical devices including monofilament sutures.
    Type: Grant
    Filed: December 14, 2000
    Date of Patent: January 7, 2003
    Assignee: Poly-Med, Inc.
    Inventor: Shalaby W. Shalaby
  • Patent number: 6498229
    Abstract: The present invention is directed to a method for the direct, one-step synthesis of crystalline segmented glycolide copolymers having less than 80 percent glycolide-based sequences in the copolyester chain. The copolyester chain can also be formed using a polyether glycol as the initiator for the ring-opening copolymerization of glycolide and other cyclic monomers to form highly hydrophilic materials.
    Type: Grant
    Filed: September 5, 2001
    Date of Patent: December 24, 2002
    Assignee: Poly-Med, Inc.
    Inventor: Shalaby W. Shalaby
  • Patent number: 6462169
    Abstract: An absorbable crystalline, monocentric polyaxial copolymer comprising a central carbon or nitrogen atom and at least three axes, each of which includes an amorphous flexible component adjacent and originating from the central atom and a rigid, crystallizable component extending outwardly from the amorphous, flexible component is disclosed along with the use of such copolymer in medical devices which may contain a bioactive agent.
    Type: Grant
    Filed: October 27, 2000
    Date of Patent: October 8, 2002
    Assignee: Poly-Med, Inc.
    Inventor: Shalaby W. Shalaby
  • Patent number: D503803
    Type: Grant
    Filed: August 17, 2004
    Date of Patent: April 5, 2005
    Assignee: Poly-Med, Inc.
    Inventors: Shalaby W Shalaby, Bruce L. Anneaux, M. Scott Taylor