Abstract: This invention deals with a tissue protecting, spray-on film composition comprising an amphiphilic film-forming, segmented/block copolymer derived form at least one water-soluble monomer and at least another water-insoluble monomer, wherein the film can be formed from a water soluble organic solvent such as 2-propanol, acetone, and ethyl acetate. The film can contain a bioactive agent including those to have antimicrobial, anesthetic, anti-inflammatory, and wound-healing activities.
Type:
Grant
Filed:
July 5, 2005
Date of Patent:
November 30, 2010
Assignee:
Poly-Med, Inc.
Inventors:
Shalaby W. Shalaby, James M. Lindsey, III
Abstract: Composite fibrous constructs are made of combinations of inorganic-organic hybrid monofilament or multifilament yarns containing at least 6 weight percent of inorganic micro-/nanoparticles and organic monofilament or multifilament yarn with typical examples of the hybrid yarn matrix made of absorbable or non-absorbable thermoplastic polymers and final constructs being in the form of knitted or woven meshes and braided ligatures intended to perform under specific mechanically, biologically, and/or radiologically related functions.
Type:
Grant
Filed:
June 23, 2009
Date of Patent:
October 26, 2010
Assignee:
Poly-Med, Inc.
Inventors:
Shalaby W Shalaby, Kimberly A Carpenter, Kenneth W Clinkscales
Abstract: A thermally printable commercially functional cash register tape produced from a thin oriented, heat stabilized, thermoplastic film is described. This thermoplastic tape replaces the currently used paper cash register tape. It will accept printing, has sufficient machine direction stiffness and sufficiently reduced surface electrical charges to function in conventional commercial cash register printers. The thermoplastic tape is much thinner than the conventional paper tape so a roll of the plastic register tape contains about 4.7 times the paper length of a typical cash register roll.
Abstract: A modified, mesophase pitch-based carbon fiber is disclosed which includes carbon nanotube reinforcements in an amount ranging from about 0.01 percent to about 1.0 percent by weight. Although the reinforcements actually decrease the excellent tensile modulus of the unmodified fiber, they provide a random microstructure, which can decrease brittle failure of the fiber caused by propagation of a flaw.
Type:
Grant
Filed:
September 12, 2003
Date of Patent:
December 26, 2006
Assignee:
Clemson University
Inventors:
Amod A. Ogale, Dan D Edie, Apparao M. Rao
Abstract: Absorbable heterochain polymers carrying acid or basic groups, capable of ionic conjugation with basic or acidic bioactive agents, respectively, are produced by free-radical addition of unsaturated functional monomers onto absorbable liquid polymers and subsequent generation of reactive functionality or by direct copolymerization of a carboxylic initiator with cyclic monomers to produce liquid carboxyl-bearing copolyesters or polyester carbonates.
Abstract: The present invention is directed to crystalline copolymers of l-lactide and a minor portion of a cyclic monomer, preferably ?-caprolactone or trimethylene carbonate or both. The present copolymers have a melting temperature of at least 150° C. and a crystallinity of at least 20%. Preferred are high molecular weight copolymers having an inherent viscosity of at least 1.1 dl/g. A variety of surgical constructs may be formed from the present copolymers. Disclosed are coated surgical constructs including sutures made of multifilament yarns of the present copolymers and coated with nitrogenous copolyesters which will bioabsorb in less than three years and will maintain at least 50% of their initial strength three weeks post-operatively.
Abstract: An amplifying optical element for use within an optical fiber communication system is disclosed which includes a doped optical fiber, an optical excitation source which is physically integrated with and immediately adjacent to and surrounding doped optical fiber, the excitation source being capable of emitting sufficient light to enable power gain of the signal being transmitted, and an external power source electrically connected to the optical excitation source for initiating and maintaining the light emission. Preferably, the excitation source is a multilayer electrically conductive structure which includes a first layer immediately adjacent to the doped optical fiber, wherein the first layer is a transparent, electrically conductive material, a second layer adjacent to the first layer, wherein the second layer is an electroluminescing material, and a third layer adjacent to the second layer, wherein the third layer is an electrically conductive material.
Abstract: An absorbable crystalline, monocentric polyaxial copolymer comprising a central carbon or nitrogen atom and at least three axes, each of which includes an amorphous flexible component adjacent and originating from the central atom and a rigid, crystallizable component extending outwardly from the amorphous, flexible component is disclosed along with the use of such copolymer in medical devices which may contain a bioactive agent. The present invention also relates to a suture, stents, stent mantles and sealing devices made from the polyaxial copolymer.
Abstract: The present invention is directed to surface functionalized fabrics, particularly those based on non-woven polypropylene, wherein the functional groups are capable of binding antimicrobial agents through ionic conjugation to control their release and prolong their antimicrobial activity. The invention also deals with Nylon 6 fabric that is complexed with iodine to control its release and to achieve prolonged antimicrobial activities. Similarly, polypropylene and cellulosic fabrics grafted with N-vinylpyrrolidone are disclosed. The N-vinylpyrrolidone can also complex with iodine to control its release and provide antimicrobial activity over desired periods of time.
Abstract: A system by which a portable computer on a cart translates warehouse locations to light addresses of locations on storage bays in a storage facility and communicates instructions by means of a bi-directional, dual transmitter/receiver element on the cart to a pick-controller unit positioned on each bay. The pick-controller unit on the bay is connected with intelligent light assemblies at each location on the bay that, in response to instructions from the portable computer, illuminate indicating the need for, and quantity of a SKU to be retrieved from the illuminated location. In addition, the portable computer communicates instructions using the bi-directional, dual transmitter/receiver element to the put-controller unit positioned on the cart that in turn communicates these instructions to intelligent light assemblies adjacent to specific receptacles located on the cart.
Abstract: The present invention is directed to bioabsorbable adhesive/hemostatic formulations of a 2-alkoxyalkylcyanoacrylate and liquid or solid polymeric modifiers and adjuvant. The present adhesive formulations are useful as tissue adhesive/sealants, hemostatic agents, and as a means for patching or anastomic coupling of damaged organs.
Abstract: The present invention is directed toward cyanoacrylate-based tissue adhesive or sealant compositions comprising cyanoacrylate-capped heterochain polymers, such as those comprising one or more oxyalkylene, alkylene carbonate, and ester-units derived from cyclic lactones. Such compositions can be radiochemically sterilized and used in repairing internal organs or tissue blocking body conduits.
Abstract: The present invention is directed to surface functionalized fabrics, particularly those based on non-woven polypropylene, wherein the functional groups are capable of binding antimicrobial agents through ionic conjugation to control their release and prolong their antimicrobial activity. The invention also deals with Nylon 6 fabric that is complexed with iodine to control its release and to achieve prolonged antimicrobial activities. Similarly, polypropylene and cellulosic fabrics grafted with N-vinylpyrrolidone are disclosed. The N-vinylpyrrolidone can also complex with iodine to control its release and provide antimicrobial activity over desired periods of time.
Abstract: An improved method for preparing low density ceramics is described wherein the process incorporates paper residuals which are a by-product of the paper recycling process. The method for making a low density-ceramic comprises the steps of:
a) providing a paper residual comprising from about 0.5 to about 99 percent, by weight, of at least one filler, from about 0 to about 20 percent, by weight, of a dye, from about 0 to about 10 percent, by weight, of an ink, from about 0.5 to about 99.5 percent, by weight, of paper fiber, and from about 0 to about 30 percent, by weight, of other components, based on a dry weight of the residual;
b) admixing a ceramic material with the paper residual, the ceramic material comprising up to about 90%, by weight, of the admixture, based on a dry weight of the admixture;
c) forming the admixture into a desired shape; and
d) firing the admixture to a temperature ranging from about 1850° F. to about 2900° F.
Abstract: A variety of phosphonylated heterochain polymers are disclosed, including, most preferably, phosphonylated polymethyl methacrylate. For each polymeric composition the phosphorous atom of a phosphorous-containing functional group is covalently bonded to a carbon atom of the polymeric chain. The phosphorous atoms are present in an amount of at least about 0.1 percent by weight in each polymeric composition.
Abstract: This invention deals with an absorbable, gel-forming composition for multifaceted prevention of post-operative surgical adhesion through a plurality of physico-pharmacological modes, comprising a solution of one or more bioactive compounds in a liquid copolymeric vehicle made by end-grafting one or more cyclic monomer onto a polyalkylene glycol. More specifically, the bioactive drugs can display one or more pharmacological activity associated with antiangiogenic, antineoplastic, anti-inflammatory, and anti-proliferative effects.
Type:
Grant
Filed:
April 24, 2002
Date of Patent:
April 22, 2003
Assignee:
Poly-Med, Inc.
Inventors:
Shalaby W. Shalaby, Waleed S. W. Shalaby, Marc Shalaby
Abstract: The present invention is directed to crystalline, absorbable block/segmented copolymers which are the reaction product of a linear prepolymer which is a polytrimethylene dicarboxylate of succinic, glutaric, or adipic acid and either glycolide, 1-lactide, or mixtures thereof. Preferably the prepolymer is preliminarily end-grafted with a further monomer such as trimethylene carbonate or &egr;-caprolactone. The crystalline copolymers of this invention are tailored for fabrication into several forms of absorbable biomedical devices including monofilament sutures.
Abstract: The present invention is directed to a method for the direct, one-step synthesis of crystalline segmented glycolide copolymers having less than 80 percent glycolide-based sequences in the copolyester chain. The copolyester chain can also be formed using a polyether glycol as the initiator for the ring-opening copolymerization of glycolide and other cyclic monomers to form highly hydrophilic materials.
Abstract: An absorbable crystalline, monocentric polyaxial copolymer comprising a central carbon or nitrogen atom and at least three axes, each of which includes an amorphous flexible component adjacent and originating from the central atom and a rigid, crystallizable component extending outwardly from the amorphous, flexible component is disclosed along with the use of such copolymer in medical devices which may contain a bioactive agent.