Abstract: A novel method for the detection, screening, the quantitation of compounds that interact with nucleic acids (DNA or RNA) is provided. The basis for this method is the inhibition of acridine orange binding to the nucleic acid. Measurement of binding inhibition utilizes the rapid, repeatable technique of fluorescence polarization.

Abstract: Compounds of the structure: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, and R.sub.6 are hydrogen, alkyl, alkenyl, alkynyl, phenyl-alkyl, or cycloalkyl,n is an integer from 0 to 4 inclusive,M is alkenyl, alkynyl, cycloalkyl, cycloalkyl-alkyl, polycycloalkyl, polycyclo-alkyl-alkyl, aryl, aralkyl, heteroaryl, heteroaryl-alkyl, hetero-cycloalkyl, hetero-cycloalkyl-alkyl, alkoxyalkyl, alkylthioalkyl, alkylamino-alkyl, dialkylamino-alkyl, fused aryl-cycloalkyl, fused aryl-cycloalkyl-alkyl, fused heteroaryl-cycloalkyl, or fused heteroaryl-cycloalkyl-alkyl,Y is hydroxy, alkoxy, amino, or substituted amino, aminoalkanoyl, aryloxy, aminoalkoxy, or hydroxyalkoxy, andR.sub.7 is hydrogen, alkanoyl, carboxylalkanoyl, hydroxyalkanoyl, amino-alkanoyl, cyano, amidino, carbalkoxy, ZS, or ##STR2## wherein Z is hydrogen, alkyl, hyroxyalkyl, aminoalkyl or the radical ##STR3## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.

Abstract: A method for the treatment of pathological processes in bone and connective tissue comprises the topical application of calcitonin to effect control of said processes by transepithelial action. Preferred compositions for use in the method are ear drops comprising an aprotic solvent or an aqueous medium containing a surface active agent.

Abstract: New pyridothienotriazines are described. These compounds are useful as anti-allergic reagents.

Abstract: A sheath for holding a temperature sensing unit in place in the hair wrapped around a curling rod, comprising a top elongated channel portion, a pair opposed downwardly and outwardly projecting curved wings connected to the channel, the radius of curvature of the wings increasing with the distance from the channel and a hollowed out portion below the channel.

Abstract: A laser beam is used to provide rapid, clear and permanent marking of plastic lenses.

Abstract: A device for selecting a curling rod of a specified diameter to provide a curl of selected size and configuration in permanent waving with a reducing medium of known composition, comprising a card which is provided with a horizontal tapered slot which has an enlargement beyond its widest end, a plurality of pairs of aligned vertical guide lines both above and below the slot, and in substantial alignment with each pair of guide lines a depiction of a curl showing its approximate size and configuration as obtained by the use of the curling rod of the measured diameter.