Abstract: A method for culturing fungal and plant cells in a culture medium containing an elicitor to increase production of a metabolite produced by the cells. For example, tobacco leaves produce the metabolite nicotine and the nicotine is produced in significantly greater amounts when the tobacco is cultured in a elicitor-containing medium. The elicitor is an oxidized Bovine Serum Albumin (BSA), or a glycosylated BSA, or an oxidized lysozyme, or glycosylated lysozyme or azetidine-2-carboxylic acid. Further, metabolite production is increased 1000% over the production of the metabolite when an elicitor is not added during the culturing method.

Abstract: Provided by this invention is an improved animated light signage device in which no electrical line connecting to an electrical wall outlet is used and no internal light source is used. The device has an animation element through which light flows and is forwarded through optical fibers to provide an animated light signage in one or more display face panels. A process for providing animated light signage by use of the device is also a part of the invention.

Abstract: Peptides having two or more amino acid residues in the sequence of the amino acid residues of vasoactive intestinal peptide (VIP) segment 11-28, analogs and derivatives thereof and pharmaceutically acceptable salts thereof are provided which are characterized by inducing analgesia by delivery to the central nervous system when administered to a mammal. Also provided is a method of inducing analgesia by delivery to the central nervous system using direct or indirect routes to administer VIP peptide segment 11-28, peptides having two or more amino acids of sequence of the VIP peptide segment, analogs and derivatives thereof and pharmaceutically acceptable salts thereof. Additionally are provided analgesic pharmaceutical compositions of said peptides, analogs and derivatives thereof or pharmaceutical salts thereof and a pharmaceutically acceptable carrier therefore.

Abstract: Provided by this invention are two-part liquid polysulfide compositions which utilize stable and effective manganese dioxide or like curing agents which provide reasonable working times and gel times typically a maximum of 90 minutes and desirably rapid cure rates. Also, provided are stable and effective manganese curing compositions suitable for use as an element of such two-part liquid polysulfide compositions.

Abstract: The invention provides a process for stimulating the multiplication, differentiation or somatic embryogenesis of higher plant cells in tissue culture by the addition to the culture medium an effective amount of extensin preparation derived from higher plant tissue. Also, provided are tissue cultures which have such stimulating amount of extensin present. Finally, provided by the invention is the sterile extensin preparation which has the stimulating activity, preferably the extensin used being pure or substantially pure.

Abstract: Provided by the invention are methods and compositions for increasing the growth rate and feed efficiency of turkeys by administration of an effective amount of 5-alpha-dihydrotestosterone or biocompatible derivatives such as alkanoic acid ester derivatives, as an implant.

Abstract: Provided are fat substitute compositions adapted for use in food. The compositions are stable at temperatures at which foods are normally heated in preparation, such as about 350.degree. F., are in the form of water-insoluble microparticles, and are made from orally ingestible proteins. Also provided are processes for the use and manufacture of the microparticle compositions.

Abstract: A humidity sensor device which utilizes a humidity-sensitive piezoelectric polymer film as a transducer element. In a preferred embodiment a pair of excitation electrodes and a pair of pickup electrodes are provided on such a polymer film, a suitable excitation voltage is applied to the excitation electrodes and the resultant transverse piezoelectric effects are detected in the form of an electrical output voltage from the pickup electrodes. The electrical output signal is converted to the humidity value of the gaseous environment based on a prior calibration. Typically, an odd nylon such as nylon-11 or nylon-7 is used for the piezoelectric element and a rectangular, uniform and porous graphite films are deposited thereon as electrodes. The humidity sensor device of this invention can be used over a wide temperature range and can withstand repeated exposure to harsh temperature conditions over a long period of time.

Abstract: Provided are disposable dosage units for use in iontophoresis-facilitated transdermal delivery which have hydrophilic polymer first and second layers, the first layer having ionic resin particles dispersed therein and the second layer having an ionized pharmaceutical contained. The second layer having on its surface a thin fabric layer bearing an adhesive layer. The polymer first and second layers are separated by a permselective membrane. Also provided are related devices and processes using the novel disposable dosage units.

Abstract: Provided by this invention are piezoelectric laminate films wherein films of different polymers are in laminated relationship. The piezoelectric laminate film has at least one property which is superior to the corresponding property in the films used in the lamination to form the laminate. Also provided is a method for making the laminate.

Abstract: This invention relates to a polarized material which has polarization which is essentially stable up to the crystal melting temperature range of the polar crystals or to the softening temperature range or the glass transition temperature range of the polarized material if it is non-crystalline. A preferred polarized material provided is poly(vinylidene fluoride), blends of poly(vinylidene fluoride) and vinylidene copolymer and blends of odd Nylons such as Nylon-7 and Nylon-11.

Abstract: Transdermal fertility-controlling absorption polymer matrix dosage units have been developed which comprise a backing layer, an adjoining layer of a solid polymer matrix in which minimum effective daily doses of an estrogen and a progestin are microdispersed and released for transdermal absorption. Presently preferred is use of the natural estrogen, 17-beta-estradiol, and of the progestin, levonorgestrel. The units have a biologically acceptable adhesive polymer layer. The polymer matrix as well as the adhesive layer can have dispersed one or more skin permeation enhancers. Dosage units are provided which transdermally deliver at least minimum daily doses of the estrogen and progestin for multiple days, such as for one week. The invention also provides a process of fertility control using the novel polymer matrix dosage units for the first three weeks of consecutive menstrual cycles of the subject desiring fertility control.

Abstract: Provided are reservoir electrodes for iontotherapeutic devices which have two chambers; the first chamber is electrically connected to the iontotherapeutic device and is designed to contain electrolytic solution and the second chamber has ionized pharmaceutical dissolved in electrolytic solution. The two chambers are separated by a permselective membrane. The first chamber has means to inhibit increase in ionic content caused by the operation of the iontotherapeutic device. Also provided are unit dose forms adapted for insertion into the reservoir electrodes. The dose unit forms are made of crosslinked polymer and contain ionizable pharmaceutical which is released for absorption during operation of the iontotherapeutic process. Also provided are novel iontotherapeutic devices and processes.

Abstract: The provided invention is a novel electrostrictive driving device which comprises a sonic wave projector element having alternating electrodes and polymer material film layers. The device provides when subjected to a high bias voltage and a superimposed A.C. voltage, a high Angstroms/Volt response. Also, provided is a process for projecting sonic waves using the electrostrictive driving device of this invention.

Abstract: Provided by the invention are methods and compositions for increasing the growth rate and feed efficiency of turkeys by administration of an effective amount of the intermediate synthesis compound 19-nortestosterone. It has also been found that the invention provides increased muscle mass in the resulting turkey carcasses with a decreased percentage of fat mass and substantially no increase in skeletal growth over that of control turkeys.

Abstract: This invention relates to a polarized material which is free or substantially free of mechanically-induced orientation and has polarization which is essentially stable up to the crystal melting temperature range of the polar crystals or to the softening temperature range or the glass transition temperature range of the polarized material if it is non-crystalline. A preferred polarized material provided is poly(vinylidene fluoride).

Abstract: Transdermal absorption dosage units have been developed for treatment of postmenopausal syndrome which comprise a backing layer, an adjoining adhesive polymer layer in which at least minimum effective daily doses of an estrogen is microdispersed. Presently preferred is use of the natural estrogen, 17-beta-estradiol, or ethinyl estradiol or combinations thereof together with an amount of a natural progestogen or a progestin to minimize any potential side effects. The units use bioacceptable adhesive and polymers. An additional polymer layer in intimate contact with the estrogen-containing layer can be used. Also, a separating layer can optionally be used in making the dosage units, which separate the two adhesive polymer layers, which permits estrogen transmission from the first adhesive polymer layer during treatment. Dosage units are provided which transdermally deliver at least minimum daily doses of the estrogen for at least one day or for multiple days, such as for one week.

Abstract: Provided by this invention are thixotropic polymer compositions, which are useful upon curing to make tough coatings, sealants, adhesive bonds and molds. The compositions can be supplied to the site of use as two low viscosity liquid parts, which when mixed provide rapid onset of thixotropy. One or more polyisocyanates and one or more aromatic diamines are used in making the compositions. Processes for making coatings, sealants, adhesive bonds and molds by use of the compositions are also provided.

Abstract: This invention relates to homogeneous compositions comprising pulped paperboard and a finely divided polymer, suitably polyethylene terephthalate, commonly referred to as "PET". Also, provided are stable aqueous dispersions of finely divided polymer particles, preferably of micronic or submicronic range particle size. Processes for providing the novel compositions of the invention are also provided.

Abstract: Provided is an ultraviolet radiation device useful to measure intensity of the ultraviolet radiation in a selected environment which has an optical-electrical converter having an optical means for expanding an ultraviolet radiation input angle of the converter, a temperature sensor and an electrical signal conditioner having means to generate an ultraviolet intensity signal which is independent of ambient temperature. A preferred device is for personal use and permits allocation of measured daily doses of solar ultraviolet radiation over multiple days to provide a predetermined total cumulative amount of ultraviolet radiation and a desired tanning of skin during sunbathing. The preferred device issues a signal when the daily allocated dose is reached. The invention also provides by using the device of the invention a process to determine prevailing ultraviolet radiation levels and cumulative amounts and a controlled process for tanning.