Abstract: Disclosed are compounds of the formula:
and the pharmaceutically acceptable salts thereof wherein Q, X, Y, Z, and R1 R9, and R12-R19 are defined herein.
These compounds are selective modulators of MCH 1 receptors that are, therefore, useful in the treatment of a variety of metabolic, feeding, and sexual disorders. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also disclosed.
Type:
Grant
Filed:
July 6, 2001
Date of Patent:
May 27, 2003
Assignee:
Neurogen Corporation
Inventors:
Rajagopal Bakthavatchalam, Andrew Thurkauf, Alan Hutchison