Abstract: The present invention relates to therapeutic methods wherein an actin-binding protein, preferably gelsolin or DBP, is administered to a patient with actin-containing clots in order to remove actin from the clots. The invention also relates to diagnostic methods in which actin is removed from an actin-containing clot in vitro and quantitated.
Type:
Grant
Filed:
August 14, 1992
Date of Patent:
November 25, 1997
Assignee:
Biogen, Inc.
Inventors:
Paul A. Janmey, Jennifer A. Lamb, Stuart E. Lind, Thomas P. Stossel