Patents Represented by Attorney Lester E. Johnson
  • Patent number: 4499073
    Abstract: A composition is disclosed which comprises a solution in a pharmaceutically acceptable carrier of an immune serum globulin, said solution having an ionic strength and a pH to maintain the monomer content and the actual and latent anticomplement activity of the immune serum globulin such that the composition is intravenously injectable. Novel methods are disclosed for preparing the above composition.
    Type: Grant
    Filed: April 18, 1983
    Date of Patent: February 12, 1985
    Assignee: Cutter Laboratories, Inc.
    Inventor: Robert A. Tenold
  • Patent number: 4496689
    Abstract: There is disclosed a process for producing a covalently attached alpha-1-proteinase inhibitor - water soluble polymer complex useful for pulmonary emphysema therapy, a covalently attached alpha-1-proteinase inhibitor - water soluble polymer complex produced by the process, a composition thereof in a pharmaceutically acceptable carrier, and a method for treating pulmonary emphysema by administering to a human patient a therapeutically effective amount of the complex or preparation.
    Type: Grant
    Filed: December 27, 1983
    Date of Patent: January 29, 1985
    Assignee: Miles Laboratories, Inc.
    Inventor: Gautam Mitra
  • Patent number: 4477432
    Abstract: There is disclosed an oral pharmaceutical composition for therapeutic use comprising a therapeutically effective amount of orally administerable immune globulin in a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: April 5, 1982
    Date of Patent: October 16, 1984
    Assignee: Cutter Laboratories, Inc.
    Inventor: W. Richard Hardie
  • Patent number: 4473553
    Abstract: There is disclosed a process for producing coagulation factors VII and VIIa in relatively high purity by contacting an aqueous preparation containing factors VII and VIIa with a lipoprotein binding adsorbent and separating the coagulation factors and other proteins therefrom, contacting the resulting lipoprotein-poor solution with a divalent metal salt adsorbent having selective affinity for calcium-binding coagulation factors and eluting the coagulation factors therefrom, and contacting the eluate with an anionic exchange resin and selectively eluting coagulation factors VII and VIIa therefrom by step or gradient elution techniques to obtain factors VII and VIIa free of other coagulation factors and other proteins.
    Type: Grant
    Filed: December 2, 1983
    Date of Patent: September 25, 1984
    Assignee: Miles Laboratories, Inc.
    Inventors: Timothy R. Zuffi, Nazreen Pancham
  • Patent number: 4470969
    Abstract: There is disclosed a process for producing coagulation factors VII and VIIa in relatively high purity by contacting an aqueous preparation containing factors VII and VIIa with a protein precipitant and separating the coagulation factors and other proteins therefrom, contacting the resulting solution with a divalent metal salt adsorbent having selective affinity for calcium-binding coagulation factors and eluting the coagulation factors therefrom, and contacting the eluate with an anionic exchange resin and selectively eluting coagulation factors VII and VIIa therefrom by step or gradient elution techniques to obtain factors VII and VIIa free of other coagulation factors and other proteins.
    Type: Grant
    Filed: December 2, 1983
    Date of Patent: September 11, 1984
    Assignee: Miles Laboratories, Inc.
    Inventors: Nazreen Pancham, Timothy Zuffi
  • Patent number: 4470968
    Abstract: Compositions containing a concentrate of coagulation Factors II, VII, IX, and X are pasteurized without substantial loss of therapeutic activity by mixing the protein composition with a pasteurization-stabilizing amount of a polyol and a source of citrate ions prior to pasteurization. Pasteurized compositions containing a concentrate of coagulation Factors II, VII, IX, and X, which have heretofore been unattainable, can be prepared by the method of the invention.
    Type: Grant
    Filed: January 13, 1983
    Date of Patent: September 11, 1984
    Assignee: Miles Laboratories, Inc.
    Inventors: Gautam Mitra, Paul K. Ng
  • Patent number: 4455301
    Abstract: Novel antihemophilic factor concentrates and process for making the same are disclosed. An aqueous solution of anithemophilic factor proteins is obtained, preferably by solubilizing antihemophilic factor proteins from blood plasma cryoprecipitate in water. The aqueous solution is purified to remove unwanted protein, for example, by mixing the aqueous solution with aluminum hydroxide. Then, the aqueous solution is ultrafiltered to concentrate it, mixed with buffer and saline and adjusted to an acid pH, and freeze-dried.
    Type: Grant
    Filed: September 29, 1982
    Date of Patent: June 19, 1984
    Assignee: Cutter Laboratories, Inc.
    Inventors: Gautam Mitra, John L. Lundblad
  • Patent number: 4455300
    Abstract: Novel compositions containing fibronectin and methods of isolating these compositions and fibronectin itself from blood plasma are disclosed.
    Type: Grant
    Filed: May 25, 1982
    Date of Patent: June 19, 1984
    Assignee: Cutter Laboratories, Inc.
    Inventors: Donald G. Wallace, Phillip M. Schneider, John L. Lundblad
  • Patent number: 4452893
    Abstract: Fraction IV, a discard fraction of the Cohn fractionation scheme, may be used as a supplement in cell growth media if the Fraction IV is rendered substantially free of components within the molecular weight range 2.5.times.10.sup.5 -1.0.times.10.sup.10, which components inhibit cell growth.
    Type: Grant
    Filed: August 3, 1981
    Date of Patent: June 5, 1984
    Assignee: Cutter Laboratories, Inc.
    Inventors: Paul K. Ng, Milton B. Dobkin
  • Patent number: 4450104
    Abstract: A lectin-containing, water-insoluble gel matrix with a glycoprotein reversibly bound thereto can be used for fractionating a polysaccharidic substance capable of being separated into components of differing activity by virtue of differing affinity for the glycoprotein. In this manner, heparin can be fractionated into high activity and low activity components.
    Type: Grant
    Filed: September 29, 1982
    Date of Patent: May 22, 1984
    Assignee: Cutter Laboratories, Inc.
    Inventor: Robert E. Jordan
  • Patent number: 4446314
    Abstract: A lectin-containing, water-insoluble gel matrix with a glycoprotein reversibly bound thereto can be used for fractionating a polysaccharidic substance capable of being separated into components of differing activity by virtue of differing affinity for the glycoprotein. In this manner, heparin can be fractionated into high activity and low activity components.
    Type: Grant
    Filed: September 29, 1982
    Date of Patent: May 1, 1984
    Assignee: Cutter Laboratories, Inc.
    Inventor: Robert E. Jordan
  • Patent number: 4446126
    Abstract: A complex of antithrombin and high activity heparin is provided for use as a potent anticoagulant for humans. The complex is prepared by reversibly immobilizing it on a lectin-containing, water-insoluble gel matrix and then removing it from the matrix.
    Type: Grant
    Filed: March 12, 1982
    Date of Patent: May 1, 1984
    Assignee: Cutter Laboratories, Inc.
    Inventor: Robert E. Jordan
  • Patent number: 4440679
    Abstract: Compositions containing thermally sensitive, therapeutically active proteins are pasteurized without substantial loss of therapeutic activity by mixing the protein composition with a pasteurization-stabilizing amount of a polyol prior to pasteurization. Pasteurized compositions containing therapeutically active proteins, which have heretofore been unattainable, can be prepared by the method of the invention.
    Type: Grant
    Filed: December 20, 1982
    Date of Patent: April 3, 1984
    Assignee: Cutter Laboratories, Inc.
    Inventors: Peter M. Fernandes, John L. Lundblad
  • Patent number: 4439358
    Abstract: A method is disclosed for separating alpha-1-proteinase inhibitor from a blood plasma fraction particularly from the Cohn fractionation scheme. An aqueous solution of the blood plasma fraction is held at a pH of about 6.5-8.5, and a temperature of about 2.degree.-50.degree. C. for a period of about 0.2-24 hours and then mixed with a poly-condensed polyglycol. The mixture may be held at a temperature of about 2.degree.-10.degree. C. for a period of about 1-24 hours. Next, the pH of the mixture is adjusted to selectively precipitate unwanted proteins from the solution of alpha-1-proteinase inhibitor which is separated from the solution and purified further. The amount of poly-condensed polyglycol and the pH of the mixture are selected accordingly.
    Type: Grant
    Filed: January 27, 1983
    Date of Patent: March 27, 1984
    Assignee: Miles Laboratories, Inc.
    Inventors: Michael H. Coan, William J. Brockway
  • Patent number: 4421902
    Abstract: There are disclosed polymerizable alkyl poly(oxyethylene) poly(carbonyloxyethylene)acrylates and copolymers thereof, especially stable, aqueous dispersions of water-insoluble emulsion copolymers of (1) about 10-70% by weight of (meth)acrylic, (2) about 0.5-25% by weight of an alkyl poly(oxyethylene) poly(carbonyloxyethylene) acrylate, and (3) at least 25% by weight, to a total of 100%, of a C.sub.1 -C.sub.4 alkyl (meth)acrylate, and, optionally included in the total monomer mixture, a small amount, about 0.05-1% by weight, of a polyethylenically unsaturated monomer. The copolymers, when neutralized and solubilized by addition of an alkali, are high efficiency thickeners for aqueous systems and have improved tolerance to ionic or electrolyte content. Typical systems that can be thickened are paint latices, dye pastes for preparations, food preparations, ionic detergents, dye pastes for textiles, pharmaceuticals, and oil well drilling muds.
    Type: Grant
    Filed: September 30, 1982
    Date of Patent: December 20, 1983
    Assignee: Rohm and Haas Company
    Inventors: Ching-Jen Chang, Travis E. Stevens
  • Patent number: 4401461
    Abstract: This invention relates to novel herbicidal compounds of the formula ##STR1## wherein X is a (C.sub.1 -C.sub.6)alkoxy group, a (C.sub.1 -C.sub.4)alkyl group, an alkoxyalkoxy group, wherein each alkyl moiety has 1 to 4 carbon atoms, a (C.sub.1 -C.sub.4)alkylamino group, a (C.sub.1 -C.sub.4)dialkylamino group, a halogen atom, a cyano group, a trifluoromethyl group, a hydroxy group, or a (C.sub.1 -C.sub.4) alkylthio group, andY is a hydrogen atom, or a halogen atom,to herbicidal compositions which contain these compounds, and to methods of controlling weeds with the herbicidal compositions.
    Type: Grant
    Filed: March 16, 1978
    Date of Patent: August 30, 1983
    Assignee: Rohm and Haas Company
    Inventors: Harold F. Wilson, Marvin H. Fleischfresser
  • Patent number: 4398942
    Abstract: There is disclosed a method for selectively regulating weed plant growth in transplanted rice fields under aquatic conditions which comprises applying to said weed plants an effective amount of a compound of the formula: ##STR1## wherein: X is selected from hydrogen, (C.sub.1 -C.sub.4) alkyl, F, Cl, Br, NO.sub.2, or SO.sub.2 C.sub.6 H.sub.5 ;R is selected from C.sub.6 H.sub.5, C.sub.6 H.sub.4 X wherein X is as defined above, straight or branched chain (C.sub.1 -C.sub.8) alkyl, (C.sub.3 -C.sub.6) saturated or unsaturated cycloaliphatic groups, C.sub.6 H.sub.5 CH.sub.2 and C.sub.6 H.sub.5 S;n is selected from O and the integers 1 and 2;A is selected from CH or C.tbd.CH; andZ is a N-heterocyclic group;or an agronomically acceptable acid addition salt thereof.
    Type: Grant
    Filed: December 22, 1980
    Date of Patent: August 16, 1983
    Assignee: Rohm and Haas Company
    Inventors: Hirotake Ikari, Kanichi Kakizaki
  • Patent number: 4387190
    Abstract: An improved autoxidizable coating and/or impregnating composition consisting essentially of:(1) from about 35% to about 80% by weight, based on the total weight of components (1), (2), and (3), of a film-forming component selected from the group consisting of drying oils, alkyd resins, and mixtures of drying oils and alkyd resins,(2) from about 10% to about 50% by weight, based on the total weight of components (1), (2), and (3), of a polymer of a molecular weight in the range of 1,000-50,000 (Mn) polymerized from a monomer system comprising:(a) from about 40% to 100% by weight of at least one monomer selected from the group consisting of dicyclopentenyl methacrylate and dicyclopentenyloxyalkyl methacrylate, and(b) from about 60% to 0% by weight of at least one compatible monomer,(3) from 0 to about 40% by weight, based on the total weight of components (1), (2), and (3), of a reactive, non-volatile diluent monomer, and(4) an effective amount of at least one polyvalent metal salt or complex that catalyzes the
    Type: Grant
    Filed: August 3, 1981
    Date of Patent: June 7, 1983
    Assignee: Rohm & Haas Company
    Inventor: Wayne E. Feely
  • Patent number: 4376844
    Abstract: Resin-forming polyepoxides are mixed with polyoxazolidinyl compounds or polymers containing pendant oxazolidinyl groups in which the carbon atom in the 2-position of the heterocyclic ring is substituted with saturated hydrocarbon groups, such as dialkyl, or with an alkylene group forming a saturated ring with the carbon atom in the 2-position of the oxazolidinyl ring to form, in the absence of water, a stable composition which can be stored in closed containers for months without undergoing gelation. When such compositions are spread into films and the films exposed to moisture at ambient temperature, e.g., to ambient air having a relative humidity of at least 20% and temperature of about 15.degree. to 25.degree. C., the polymer serves to react with and cure the polyepoxide.
    Type: Grant
    Filed: January 20, 1982
    Date of Patent: March 15, 1983
    Assignee: Rohm and Haas Company
    Inventors: William D. Emmons, Wayne E. Feely
  • Patent number: 4373008
    Abstract: The present invention is concerned with, as a hydrocurable composition, a mixture of an oxazolidine-functional polymer and a compound of a monomeric or polymeric character having a plurality of acryloxy groups. The first-mentioned polymer contains a plurality of pendant groups containing 2,2,-dialkyl oxazolidine groups. The mixture of these two components can be stored under anhydrous conditions in a closed container without co-reaction so that a one-pot or one-package composition can be made up with many conventional ingredients of coating compositions other than aqueous components and stored without gelling until the time for application when the composition may be applied at ambient temperature and humidity whereupon reaction between the main two components mentioned above occurs in the film deposited and the film set up.
    Type: Grant
    Filed: November 9, 1981
    Date of Patent: February 8, 1983
    Assignee: Rohm and Haas Company
    Inventors: William D. Emmons, Wayne E. Feely