Abstract: A colony stimulating factor. CSF-1, is a lymphokine useful in overcoming the immunosuppression induced by chemotherapy or resulting from other causes. CSF-1 is obtained in usable amounts by recombinant methods, including cloning and expression of the murine and human DNA sequences encoding this protein.

Abstract: A virion expression system for a desired protein packaged in an envelope derived from a retrovirus useful in administering proteins which cross cell membranes in order to serve their function. Preferred virions are those that carry an RNA sequence that encodes cytokines or lymphokines, and includes IL-2, multiple drug resistance protein, and TNF. Particularly disclosed is a DNA construct in which a gene encoding tumor necrosis factor (TNF) is directly linked to DNA encoding a human .gamma.-interferon signal peptide.

Abstract: Compositions useful for detecting ras gene proteins are described consisting of GTP and a protein having an apparent reduced molecular weight of about 115,000-120,000 daltons, or fragments derived therefrom, that stimulate ras protein guanosine triphosphatase activity. Also described are methods whereby the compositions are used to identify cancer therapeutics.

Abstract: A vaccine is described for prevention of gastro-enteric disease caused in a mammalian species by a pathogenic microorganism. The vaccine comprises a non-pathogenic microorganism strain containing stable replicative plasmids, each having one or more genes non-indigenous to the plasmid. The non-indigenous genes are either genes for an adhesin necessary for adherence of the pathogenic microorganism in the mammalian species or are genes for toxoids of toxins causative of the disease. Both types of genes may also be included in the same plasmid.

Abstract: Shipping fever, and other stress-related diseases in livestock, are treated by administration of a microencapsulated composition comprising IL-2 conjugated with a polyoxyethylene polymer, and mixed with a release-modulating amount of humen serum albumin. The microcapsules are administered parenterally, and release an effective amount of conjugated IL-2 continuously over a period of 14-30 days. These microcapsules are also effective in the treatment of cancer in mammals.

Abstract: A packing material useful in a gravel pack for open or cased wells or in a prepack for use in steam or hot fluid injection and production wells. The packing material is a material which is insoluble in high temperature caustic fluids and subsurface formation fluids. Sintered bauxite is a claimed material.

Abstract: A packing material useful in a gravel pack for open or cased wells or in a prepack for use in steam or hot fluid injection and production wells. The packing material is a material which is insoluble in high temperature caustic fluids and subsurface formation fluids. Sintered bauxite is a claimed material.

Abstract: A method and apparatus for measuring Reid Vapor Pressure, as defined in the ASTM D-323 procedure, of liquid hydrocarbon materials wherein a sample of material is drawn from a sample can into a sample chamber containing a bellows and then to a measuring chamber. An expansion chamber, containing a bellows, connects with a measuring chamber for adjusting the amount of air within the measuring chamber and for setting the pressure within the measuring chamber before introduction of the sample so that RVP measurement occurs at the appropriate pressure.

Abstract: Methods and apparatus for removing combustion chamber deposits during normal engine operation by advancing spark timing during intermittent series of compression strokes for each cylinder of a spark-ignition, internal-combustion engine in turn.

Abstract: A method and apparatus is described for producing viscous petroleum from a subsurface formation. The apparatus includes a generally horizontal cased well through the subsurface formation with injection and production tubings within the well. The casing is perforated and the inner tubings carry a movable packer and a rotatable agitator. The method comprises injecting a heating and drive fluid for moving heated viscous petroleum through the perforations in the casing and into the well for production to the wellhead. Production is monitored for the ratio of produced packer fluid and viscous petroleum. Based on that ratio, the packer is moved within the casing to positions along the horizontal well to maximize production of petroleum. The rotatable agitator assists in removal from the well bore of formation solids produced with the viscous petroleum.

Abstract: An electrically powered vehicle transportation system including improvements in an electrified roadway system and a vehicle for operation on the roadway. The roadway is energized in response to the presence of a vehicle having certain control systems and only when that vehicle satisfies certain predetermined conditions which provide safety features for foot traffic on the roadway system. The vehicle includes means for controlling energization of the roadway in response to actions and demands within the vehicle. Automatic control means are provided to maintain the vehicle in alignment with the roadway energization system.

Abstract: A method for packing particulate material in the annulus surrounding a liner in a subsurface well having a substantial deviation from vertical. Foam carrier fluid is employed for placing the particulate material. The geometry of the apparatus at the location where the material is to be placed is described.

Abstract: A system for virtual time base direct synchronization in which a hopping sequence signal grossly synchronized with a received hopped base band has a fine synchronization correction performed by a virtual time shift of the hopping reference through first derivative subtraction of the phase of a hopped carrier signal, which in effect brings the hopping sequence signal into time alignment with the received hopped base band.

Abstract: A permanent thermal packer is disclosed for sealing the annulus between an injection tubing string and a well casing. The packer is thermal cement and is placed from within the injection tubing string to seal a substantial portion of the annulus above the injection zone. The packer provides a means for sealing the annulus above the injection zone thus permitting insulating material to be placed in the annulus above the packer with the expectation that it will not be damaged by well bore fluids.

Abstract: An apparatus is disclosed for measuring physical properties of a sample material at controllable temperatures and pressures. The apparatus includes a sample cell for holding fluid and/or solid samples. The cell includes at least one optically transparent window permitting visual and electromagnetic energy observations of the sample. A probe functions within the cell to collect a subsample for movement to apparatus for measuring properties and for returning the subsample to the cell. One form of optically transparent window is a sapphire. The cell is intended for measurements of physical properties at temperatures from about -40.degree. F. to about +400.degree. F. and at pressures from vacuum to at least 20,000 pounds per square inch.

Abstract: A multiple use component spacer having a component platform defining an aperture, having a plurality of lead grasping portions each having forked resilient portions defining a lead receiving slot for firm engagement with the leads of a range of packages without requiring the use of adhesives, having a plurality of lead abutment portions on its circumference, and having a plurality of feet on at least one surface.

Abstract: An anti-torque coaxial cable connection apparatus comprising a cylindrical nut driver having a cut away portion alignable with a slot in a coaxial cylindrical wrench having a portion shaped to engage a cable adaptor having a cable adaptor portion adapted to be firmly engaged by said wrench. The alignment of the nut driver cutaway and the wrench slot forms an aperture which can be aligned over a cable inelastically joined to a cable adaptor to allow tightening in situ of a cable connector comprising a cable adaptor and a nut without interfering with said cable while the cable adaptor is firmly held to prevent damage to said inelastic joint.

Abstract: A compression spring is compressed between an internal surface of a cavity within a base and the wide end of a plunger the shaft of which passes through the compression spring and out of a conically countersunk opening of the cavity. A tapered end of a ferrule is pivotally mounted to the external end of the plunger. The ferrule is fixed in a position perpendicular to the axis of the plunger so that when the ferrule is allowed to pivot toward alignment with the axis of the plunger, the plunger is drawn into the cavity by the action of the compression spring until the tapered end of the ferrule mates with the conically countersunk external opening of the cavity restricting motion of the ferrule that is lateral to the axis of the ferrule.