Abstract: A steering system for steering a machine having opposing first and second sides with first and second pairs of rotatably mounted rear wheels disposed along the respective sides and at least one rotatably mounted, spaced front wheel. The system includes at least one first drive unit and at least one second drive unit for rotating the rear wheels of the respective pairs, and a steering input device that provides a signal to a controller that produces drive unit request signals to control the drive units to rotate the associated rear wheels along one side at rotational speeds greater than those along the other side to facilitate turning.

Abstract: A retarding system for an electric drive machine (100) includes a direct current (DC) link (312), at which a DC voltage is developed, disposed between a rectifier (206) and an inverter (208). A first contactor switch (216) electrically communicates with a first rail of the DC link (312), and a second contactor switch (216) electrically communicates with a second rail of the DC link (312). A first resistor grid (214) is connected in series between the first contactor switch (216) and the second contactor switch (216). The first resistor grid (214) dissipates electrical energy in the form of heat by conducting a current between the first rail and the second rail of the DC link (312) when the first contactor switch (216) and the second contactor switch (216) are closed.

Abstract: A multi-mode hybrid drive train offers selective operation in any one of series, parallel, and power split modes. The multi-mode hybrid drive train includes two planetary gear sets and a collection of specifically placed brakes and clutches relative to those gear sets. The first planetary gear train includes a power input for receiving power from a primary rotational power source, as well as a first sun gear, first carrier and first ring gear. The second planetary gear train similarly includes a power input as well as a second sun gear, a second carrier connected to a final drive, and a second ring gear. A first motor is linked to the first sun gear and a second motor is linked to the second sun gear such that selective activation of the clutches, brakes, and motors places the multi-mode hybrid drive train in a selected mode of operation.

Abstract: The invention provides a radiolabeled affibody molecule comprising a fragment of an IgG-binding domain of protein A from Staphylococcus aureus, a bifunctional linker, and a radiolabel comprising 18F or 76Br, wherein the bifunctional linker links the fragment and the radiolabel. The affibody molecule binds with high affinity to select receptors, which are over-expressed in certain cancers. Since the radionuclides emit a positron, the in vitro and in vivo binding characteristics of the radiolabeled affibody can be assessed using diagnostic imaging.

Abstract: The disclosure provides a method for noise generation, including: determining an initial value of a reconstructed parameter; determining a random value range based on the initial value of the reconstructed parameter; taking a value in the random value range randomly as a reconstructed noise parameter; and generating noise by using the reconstructed noise parameter. The disclosure also provides an apparatus for noise generation.

Abstract: The described system and method allow a controller to calibrate a transmission variator of a continuously variable transmission for torque control by obtaining static and dynamic qualities and parameters of the variator through an automated calibration procedure. The system and method employ a pair of transmission mode configurations and operational configurations in combination to obtain system-specific information. In this way, the system is able to calibrate out the system variations to provide effective feed forward torque control of the continuously variable transmission. In an embodiment, a first calibration operation is performed while the transmission is neutralized and a second calibration operation is performed while the transmission is engaged in a mode providing a fixed variator output speed.

Abstract: Mounting arrangement includes a drawbar assembly universally coupled to a longitudinally extending front frame portion of a machine proximal to a front wheel and a distance rearward from the wheel. An implement mounting bracket pivotably coupled to the assembly defines an articulation axis. First and second hydraulic actuators advance respective power links coupled to the mounting bracket to rotate the mounting bracket about the articulation axis. Respective idler links limit the movement of the actuators and power links.

Abstract: A method of promoting the regression of a cancer in a mammal comprising: (i) administering to the mammal nonmyeloablative lymphodepleting chemotherapy, and (ii) subsequently administering: (a) autologous T-cells, which have been previously isolated, selected for highly avid recognition of an antigen of the cancer, the regression of which is to be promoted, and rapidly expanded in vitro only once, and, either concomitantly with the autologous T-cells or subsequently to the autologous T-cells, by the same route or a different route, a T-cell growth factor that promotes the growth and activation of the autologous T-cells, or (b) autologous T-cells, which have been previously isolated, selected for highly avid recognition of an antigen of the cancer, the regression of which is to be promoted, modified to express a T-cell growth factor that promotes the growth and activation of the autologous T-cells, and rapidly expanded in vitro only once, whereupon the regression of the cancer in the mammal is promoted.

Abstract: The disclosure relates, in one aspect, to a friction brake cooling system for a machine. The cooling system includes at least one pump connected to at least one reservoir containing cooling fluid. A controller is configured to divert a cooling fluid flow through a valve to a first friction brake system and to a second friction brake system based on the use of the systems. In another aspect, the disclosure relates to a method of cooling a first friction brake system and a second friction brake system including diverting a flow of brake cooling fluid to the systems based on the use of the systems.

Abstract: A composition comprising a substantially purified compound of the formula: in combination with at least one additional therapeutic agent, and methods of preventing or treating cancer and a condition treatable by the inhibition of vacuolar-type (H+)-ATPase.

Abstract: The present invention provides an isolated or purified immunogenic peptide comprising 8-15 contiguous amino acids of gp100 (SEQ ID NO: 121) and related nucleic acids, expression vectors, host cells, populations of cells, and methods of use. The invention further provides immunogenic peptides derived from gp100 which have been modified to enhance their immunogenicity and related nucleic acids, expression vectors, host cells, populations of cells, and methods of use.

Abstract: A fuel injector and a method of assembly includes a determination of various flow areas through clearances or openings formed in various components of the injector. With the various flow areas determined, the various components can be classified according to their flow areas such that sets of components can be selected having desirable flow area characteristics for assembly of the fuel injector.

Abstract: A machine (100) includes a frame (102) portion and a tandem wheel arrangement, which includes a main linkage (312) and a stabilizing linkage (322) that are pivotally connected to the frame (102) portion. A first mount (304) and a second mount (304) are pivotally connected to the main linkage (312) and to the stabilizing linkage (322), such that the main linkage (312), the stabilizing linkage (322), the first mount (304), and the second mount (304) define a four-bar-linkage arrangement (202) that operates to transfer unbalanced torque loads from the first mount (304) and the second mount (304) to the frame (102) portion.

Abstract: An electric drive system includes a prime mover connected to a generator, which is controlled in part by an excitation current. The generator makes electrical power available on a dc link. A method of load demand and power generation balancing within the electric drive system includes determining a voltage of the dc link and determining a torque command by an operator of the system. A speed for each of one or more drive motors receiving power from the dc link is determined and normalized to derive an average motor speed. A mechanical power being commanded is derived based on the average motor speed and the torque command. A predicted excitation current that is required to achieve the derived mechanical power is determined and an actual excitation current is determined based on the predicted excitation current. The actual excitation current is then applied to the generator.

Abstract: Immunogenic peptides of a melanoma antigen recognized by T cells, designated gp100, bioassays using the peptides to diagnose, assess or prognose a mammal afflicted with cancer, more specifically melanoma or metastatic melanoma, and use of the proteins and peptides as immunogens to inhibit, prevent or treat melanoma.

Abstract: An insert for use in a remanufactured cylinder head rocker arm stand, the insert comprising an inner facing surface having a radius within a range of 35 to 45 mm and a length within a range of 70 to 103 mm, and an outer facing surface adapted for disposal against a channel in the rocker arm stand, the rocker arm shaft being disposed adjacent the inner facing surface in use, but not adjacent the rocker arm stand.

Abstract: The invention provides a method for promoting differentiation of a mature naïve B cell or a B cell progenitor into a memory B cell or a plasma cell. The method comprises (a) contacting a population of cells comprising a mature naïve B cell or a B cell progenitor with an agent that activates at least one of JAK1, JAK3, STAT3, STAT5A or STAT5B; wherein the population of cells optionally is contacted with an antigen, and (b) isolating the memory B cell or plasma cell.

Abstract: A piston actuated synchronizer system for a split torque transmission where the piston is attached directly to the synchronizer shift collar on the synchronizer centerline to provide the required actuation in a small volume of space and resolve fork and rod deflection issues seen on other synchronizers that use such a system. The piston is pressure applied and spring released. This design also uses a displacement sensor to monitor synchronizer engagement.

Abstract: The invention provides human cells, particularly human T cells, comprising a murine T Cell Receptor (TCR) having antigen specificity for the cancer antigen gp100. Isolated or purified TCRs having antigenic specificity for amino acids 154-162 of gp100 (SEQ ID NO: 1), as well as related polypeptides, proteins, nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding fragments thereof, conjugates, and pharmaceutical compositions, are further provided. The invention further provides a method of detecting the presence of cancer in a host and a method of treating or preventing cancer in a host comprising the use of the inventive materials described herein.

Abstract: Chimeric receptor genes suitable for endowing lymphocytes with antibody-type specificity include a first gene segment encoding a single-chain Fv domain of a specific antibody and a second gene segment encoding all or part of the transmembrane and cytoplasmic domains, and optionally the extracellular domain, of an immune cell-triggering molecule. The chimeric receptor gene, when transfected to immune cells, expresses the antibody-recognition site and the immune cell-triggering moiety into one continuous chain. The transformed lymphocytes are useful in therapeutic treatment methods.