Abstract: The present invention features antibodies and antibody fragments that specifically bind a CD4-inducible HIV gp120 epitope that is enhanced by binding a co-receptor for HIV, such as CCR5 or CXCR4, and pharmaceutical compositions comprising the antibodies or antibody fragments. The invention also features nucleic acids encoding the antibodies or antibody fragments, pharmaceutical compositions comprising the nucleic acids encoding the antibodies or antibody fragments, vectors comprising the nucleic acids, and cells comprising the vectors. The invention further features methods of identifying antibodies or antibody fragments with broadly neutralizing activity against HIV. The invention also features methods of inhibiting HIV entry into cells and methods of inhibiting replication of HIV in mammals, using the antibodies and nucleic acids of the invention.

Abstract: A substantially purified compound of the formula: a composition comprising a therapeutically effective amount of at least one compound of the formula, alone or in combination with at least one additional therapeutic agent, and methods of preventing or treating cancer and a condition treatable by the inhibition of vacuolar-type (H+)-ATPase.

Abstract: A semiconductor laser device includes a stacked structure. The stacked structure includes a first electrode, a substrate of a first conductivity type on the first electrode, a first cladding layer of the first conductivity type, an active layer, a second cladding layer of a second conductivity type opposite the first conductivity type, an insulating layer, and a second electrode. The second cladding layer includes at least first and second portions having thickness different from each other. The first portion is thicker than the second portion. The insulating layer is deposited on the second cladding layer but not on the first portion. The second electrode is electrically connected to the first portion. A product of a reciprocal of layer thickness and heat conductivity of the insulating layer is smaller than 4×108 W/(m2K).

Abstract: A multipoint fuel delivery system for an internal combustion engine includes fuel metering device(s) such as fuel injector(s) associated for selectively controlled injection of the second fuel to corresponding combustion chamber(s) of the internal combustion engine. A fuel supply manifold associates with fuel injector(s) for directing the second fuel to each fuel injector. An intake port adaptor mechanism adapts the intake port of the associated combustion chamber to receive the selectively controlled injection of the fuel from an associated fuel injector. The intake port adaptor mechanism may also engage the intake port so as to permit selective flow of the first fuel or the second fuel to the intake port of the selected combustion chamber. A control mechanism selectively controls the flow of the second fuel through each injector(s).

Abstract: A semiconductor light intensity modulator utilizing the electric field absorbing effect, includes a light absorption layer which absorbs light due to the electric field absorption effect and a phase correcting semiconductor layer to which an electric field is applied independently from the light absorption layer, having a larger energy band gap than that of the light absorption layer disposed in the light waveguide path or in the vicinity thereof, of the semiconductor light intensity modulator.In this construction, by adjusting the refractive index of the phase correcting semiconductor layer and the length of the light waveguide path, the change in the refractive index in the light absorption layer can be cancelled, whereby a semiconductor light intensity modulator free of phase modulation is obtained.

Abstract: Ventilation equipment with an intake of fresh air supply device and heat emitting or absorbing ceiling panels. These panels are placed laterally adjacent to the fresh air supply device, which is formed for blowing in air laterally along the underside of the panels so that the blown-air air coacts thermally with the panels.

Abstract: An apparatus for estimating a surface condition of a plate object. The apparatus comprises a lighting unit for generating light toward the plate object. A light sensor is located out of paths of the light generated from the lighting unit for producing an electrical signal in response to light of diffused reflection from the plate object. The apparatus also includes a processing unit for processing the electrical signal fed thereto from the light sensor for producing an image including a defective portion reflective of the light of diffused reflection, and an estimating unit for estimating the surface condition of the plate object based on the defective portion of the produced image. In another aspect of the invention, the apparatus comprises a lighting unit for generating light toward the plate object. A light sensor is provided for converting brightness variations of the light impinging on the plate object into an electrical signal.

Abstract: A supporting structure for a shift-control apparatus of a four wheeled buggy having a main frame and a steering wheel operated by a driver from a sitting posture, comprising a lower pipe, a pair of suspension pipes, an upper pipe, a pair of steering column pipes, a bracket supporting pipe, and brackets for supporting a shift-control apparatus, whereby the shift-control apparatus can be arranged in a central position of the main frame to facilitate the driver's manipulation with respect to a shift lever of the shift-control apparatus and to facilitate and simplify the wiring operation of a operation cable for a control system and electric wires for an electric system.