Abstract: A new use of the botanical substance Capsaicin entails application of Capsaicin to pre-malignant basal and squamous cell lesions of the epithelium. Advantageous treatment, including atrophication and de-coloration of such lesions is accomplished. The substance, which is applied topically, is employed in a potency, or concentration, of about 0.010% to 0.200% (w/w). Capsaicin in the same potency can also be employed in a base of aloe vera.