Abstract: A high refractive index, foldable polymer suitable for use in ophthalmic devices, such as intraocular lenses, is provided. The polymer may be produced from a polymerization reaction of first, second and third monomeric components and a crosslinking agent. The first monomeric component includes an aryl acrylate or an aryl methacrylate. The second monomeric component, which is not an acrylate, includes a monomer having an aromatic ring with a substituent having at least one site of ethylenic unsaturation. The third monomeric component includes a high water content hydrogel-forming monomer. The resulting high refractive index copolymer is durable enough to be cut and polished when dry, and becomes soft and foldable when hydrated.

Abstract: An iontophoretic delivery device (10) is provided. Device (10) has an electronic circuit (32) having electronic components such as batteries (30) mounted thereon. Device (10) also includes a pair of electrode assemblies (18, 19). The electronic circuit (32) is electrically connected to the electrode assemblies (18, 19) using an electrically conductive adhesive (34). The adhesive can also be used to electrically connect two or more electronic components within circuit (32) or to connect an electronic component to the electronic circuit (32). In one practice of the invention, the electrically conductive adhesive (44) functions as an electrode and electrically connects the circuit (32) to an agent-containing reservoir (24, 25). In a further practice of the invention, the electrically conductive adhesive (93) functions as an agent reservoir and contains the agent to be iontophoretically delivered.

Abstract: Octahydrofluorenyl metal complexes, such as octahydrofluorenyltitanium trichloride, or ring substituted octahydrofluorenyl metal complexes wherein the metal is in the +2, +3 or +4 formal oxidation state are prepared by reduction of tetra- or hexa-hydrofluorenyl metal complexes. The reduction reaction may be carried out at ambient pressure and temperature in the presence of a catalyst. The process of the present invention permits preparation of octahydrofluorenyltitanium metal complexes from a series of high yield reactions starting with fluorene.

Abstract: Apparatus for capillary electrophoresis having an auxiliary electroosmotic pump. Following a conventional capillary electrophoresis system having a single power supply, a separation capillary, and an optical detector, a conductive membrane connects a second capillary to a second power supply. The second capillary and second power supply act together as an auxiliary electroosmotic pump capable of augmenting or inhibiting the bulk electroosmotic flow in the separation capillary. The apparatus can be used to optimize the stacking profile of the sample and, thus, improve the separation efficiencies for charged solutes.

Abstract: Method and apparatus for flow injection analysis (FIA) using an electroosmotic pump. The apparatus includes: an electroosmotic pump having a grounding joint; a sample injection valve for introducing a sample into a carrier stream which valve is in fluid communication with the grounding joint by way of a conduit; a dispersion coil in fluid communication with the sample injection valve; and a detector which is in fluid communication with the dispersion coil. The grounding joint couples the electroosmotic pumping system and the FIA system but electrically isolates them.Generally, the method utilizes one fluid which is electroosmotically pumped to propel a carrier for flow injection analysis at a controllable flow rate. More specifically, the method includes the steps of: adding a sample to a liquid carrier stream to form a sample zone in the carrier stream; flowing a liquid pumping stream by electroosmosis; and connecting the pumping stream with the carrier stream to propel the carrier stream.

Abstract: A method of correcting for instrumental changes that influence the spectral response of a mass spectrometer over time. The method entails determining and applying a transfer function which equalizes instrument bias between mass spectrometers and within the same mass spectrometer over time. A transfer function is specific to a particular mass spectrometer, and is based on the relationship between a reference spectrum of a standard as stored in a library and a spectrum of the standard obtained on the particular mass spectrometer of interest. This method facilitates and simplifies recalibration, provides enhanced library searching capabilities for mass spectrometry, and may permit concentration determination from mass spectral data without the need to recalibrate an instrument with multiple standards.