Abstract: The application discloses novel 2-alkoxyestradiol analogs which exhibit anti-proliferative properties, and methods of making and using such compounds to inhibit undesired cell proliferation and tumor growth. Additionally, methods are disclosed of treating diseases associated with undesired angiogenesis and undesired proliferation, and methods of treating infectious disease wherein the infectious agent is particularly susceptible to inhibition by agents that disrupt microtubule organization and function.
Type:
Grant
Filed:
June 11, 2002
Date of Patent:
July 15, 2003
Assignee:
Southwest Foundation for Biomedical Research
Inventors:
Pemmaraju Narasimha Rao, Susan L. Mooberry, James W. Cessac, Tina L. Tinley